In vivo assessment of Ectoin: a randomized, vehicle-controlled clinical trial.

abstract：BACKGROUND:Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect the skin from these insults. OBJECTIVE:The aim of this study was to determine the ex vivo ascorbic acid penetration and its degradation in the skin after its topical ap...

journal_title：Skin pharmacology and physiology

authors： Leveque N,Muret P,Makki S,Mac-Mary S,Kantelip JP,Humbert P

更新日期：2004-11-01 00:00:00

abstract：:Cutaneous irritation presents a major health problem with serious social and occupational impact. The interaction between an irritant and the human skin depends on multiple factors: the intrinsic properties and the nature of the irritant itself, and specific individual- and environment-related variables. The main path...

journal_title：Skin pharmacology and physiology

authors： Fluhr JW,Darlenski R,Angelova-Fischer I,Tsankov N,Basketter D

更新日期：2008-01-01 00:00:00

abstract：:The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4-7 were applied in patch ...

journal_title：Skin pharmacology and physiology

authors： Proksch E,Soeberdt M,Neumann C,Kilic A,Reich H,Abels C

更新日期：2019-01-01 00:00:00

abstract：:A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antiox...

journal_title：Skin pharmacology and physiology

authors： Brieva A,Philips N,Tejedor R,Guerrero A,Pivel JP,Alonso-Lebrero JL,Gonzalez S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...

journal_title：Skin pharmacology and physiology

authors： Jacques-Jamin C,Duplan H,Rothe H,Vaillant O,Eilstein J,Grégoire S,Cubberley R,Lange D,Ellison C,Klaric M,Hewitt N,Schepky A

更新日期：2017-01-01 00:00:00

abstract：:The objective of the present investigation was to examine the utilization of optical and spectroscopic methods for the noninvasive characterization of Anthelios XL Fluide Extreme (SPF 50+), an exemplary sunscreen, concerning its homogeneity of distribution on the skin, its spectroscopic properties and its overall prot...

journal_title：Skin pharmacology and physiology

authors： Vergou T,Patzelt A,Schanzer S,Meinke MC,Weigmann HJ,Thiede G,Sterry W,Lademann J,Darvin ME

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES/AIMS:The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied. For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes >1 microm and 3 nano-emulsions with droplet sizes <100 nm) were tested....

journal_title：Skin pharmacology and physiology

authors： Izquierdo P,Wiechers JW,Escribano E,García-Celma MJ,Tadros TF,Esquena J,Dederen JC,Solans C

更新日期：2007-01-01 00:00:00

abstract：:Solid lipid nanoparticles (SLNs) can enhance drug penetration into the skin, yet the mechanism of the improved transport is not known in full. To unravel the influence of the drug-particle interaction on penetration enhancement, 3 glucocorticoids (GCs), prednisolone (PD), the diester prednicarbate (PC) and the monoest...

journal_title：Skin pharmacology and physiology

authors： Schlupp P,Blaschke T,Kramer KD,Höltje HD,Mehnert W,Schäfer-Korting M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The use of antioxidants has become a common practice in the development of antiaging cosmetics. OBJECTIVE:The aim of this study was to evaluate the clinical efficacy of cosmetic formulations containing lycopene and melatonin antioxidants. METHOD:Thirty-six healthy women from 32 to 65 years were enrolled in...

journal_title：Skin pharmacology and physiology

authors： Marchena AM,Franco L,Romero AM,Barriga C,Rodríguez AB

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available re...

journal_title：Skin pharmacology and physiology

authors： Wohlrab J,Neubert RH,Heskamp ML,Michael J

更新日期：2015-01-01 00:00:00

abstract：:To reduce pruritus and colonization with Staphylococcus aureus, textiles containing silver are increasingly used as therapeutic option for patients with atopic dermatitis (AD). While wearing such textiles, the contained silver is in close contact with the patient's skin. The silver serves two purposes: to reduce bacte...

journal_title：Skin pharmacology and physiology

authors： Daeschlein G,Assadian O,Arnold A,Haase H,Kramer A,Jünger M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to elucidate the effect of sample preparation and microscope configuration on the results of confocal Raman microspectroscopic evaluation of the penetration of a pharmaceutical active into the skin (depth profiling). METHODS:Pig ear skin and a hydrophilic formulation containing...

journal_title：Skin pharmacology and physiology

authors： Lunter DJ

更新日期：2016-01-01 00:00:00

abstract：:Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous...

journal_title：Skin pharmacology and physiology

authors： Wohlrab J,Neubert RH,Sommer E,Michael J

更新日期：2016-01-01 00:00:00

abstract：:Squalene is a major sebum lipid which is easily peroxidized by ultraviolet A (UVA) irradiation, generating products that can stress keratinocytes. Prevention of squalene photooxidation with antioxidants could potentially help defend skin from environmental stress. Previously, we have systematically characterized butyl...

journal_title：Skin pharmacology and physiology

authors： Zhou D,Weng X

更新日期：2019-01-01 00:00:00

abstract：:Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a co...

journal_title：Skin pharmacology and physiology

authors： Le Vu P,Takatori R,Iwamoto T,Akagi Y,Satsu H,Totsuka M,Chida K,Sato K,Shimizu M

更新日期：2015-01-01 00:00:00

abstract：AIM AND METHODS:Drug development in dermatotherapy and also development of transdermal therapeutic systems (TTS) demand high-predictive in vitro models to estimate drug levels in skin and systemic uptake. Here we compare three ready-to-use models, reconstructed human epidermis, split porcine skin and the perfused porci...

journal_title：Skin pharmacology and physiology

authors： Mahmoud A,Haberland A,Dürrfeld M,Heydeck D,Wagner S,Schafer-Korting M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. METHODS:Fifty-seven healthy full-term neonates aged < or = 48 h were randomly as...

journal_title：Skin pharmacology and physiology

authors： Garcia Bartels N,Mleczko A,Schink T,Proquitté H,Wauer RR,Blume-Peytavi U

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Cetuximab is a member of a new family of antineoplastic agents that inhibit the epidermal growth factor receptor (EGF-R), and which are increasingly being used in the treatment of solid tumors. METHODS:We have observed new secondary side effects. We present here 2 patients with acneiform eruption secondary ...

journal_title：Skin pharmacology and physiology

authors： Gencoglan G,Ceylan C

更新日期：2007-01-01 00:00:00

abstract：:Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most c...

journal_title：Skin pharmacology and physiology

authors： Fernandes AR,Santos AC,Sanchez-Lopez E,Kovačević AB,Espina M,Calpena AC,Veiga FJ,Garcia ML,Souto EB

更新日期：2018-01-01 00:00:00

abstract：:The aim of this work was to investigate in vitro the transdermal permeation of caffeine from a new bioadhesive film, using rabbit ear skin as a barrier. The effects of film composition and of the presence of penetration enhancers in the formulation were studied. The obtained fluxes were compared with those shown by co...

journal_title：Skin pharmacology and physiology

authors： Nicoli S,Amoretti V,Colombo P,Santi P

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIMS:Keloids result from aberrations in the normal wound healing cascade and can lead to pruritus, contractures and pain. The underlying mechanisms of excessive scarring are not yet understood, and most therapeutic strategies remain unsatisfactory. Psoriasin (S100A7) and koebnerisin (S100A15) are released by...

journal_title：Skin pharmacology and physiology

authors： Gauglitz GG,Bureik D,Zwicker S,Ruzicka T,Wolf R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...

journal_title：Skin pharmacology and physiology

authors： Goto K,Hiramoto K,Kawakita M,Yamaoka M,Ooi K

更新日期：2018-01-01 00:00:00

abstract：:In a clinical study, the skin penetration properties of melatonin 0.01% in a cream and 0.01 and 0.03% in a solution were investigated by evaluation of the serum melatonin levels over a 24-hour time course in 15 healthy volunteers. Blood samples for melatonin measurements were taken at 9.00 a.m. before applying the tes...

journal_title：Skin pharmacology and physiology

authors： Fischer TW,Greif C,Fluhr JW,Wigger-Alberti W,Elsner P

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics and increased skin surface area exposure. METHODS:The ability of urea, a low molecular-weight h...

journal_title：Skin pharmacology and physiology

authors： Vieille-Petit A,Blickenstaff N,Coman G,Maibach H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Acrolein is a degradation product of lipid peroxide as well as a well-known environmental pollutant. As a hallmark of oxidatively damaged protein, protein carbonyl, including acrolein-protein adduct, has been observed in the skin. However, the influence of protein carbonylation on the stratum corneum (SC) ha...

journal_title：Skin pharmacology and physiology

authors： Iwai I,Hirao T

更新日期：2008-01-01 00:00:00

abstract：AIM:The purpose of this study was to characterise C₆₀-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. METHODS:Dispersions were characterised according to their pH, particle size, zeta p...

journal_title：Skin pharmacology and physiology

authors： Souto GD,Pohlmann AR,Guterres SS

更新日期：2015-01-01 00:00:00

abstract：:Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...

journal_title：Skin pharmacology and physiology

authors： Richters R,Falcone D,Uzunbajakava N,Verkruysse W,van Erp P,van de Kerkhof P

更新日期：2015-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi), a relatively new group of epigenetic agents, are being investigated as powerful chemotherapeutics because of their antiproliferative and prodifferentiation effects both in vitro and in vivo, in various tumor cell lines. Only little is known with respect to their effects on norma...

journal_title：Skin pharmacology and physiology

authors： Lemper M,Snykers S,Vanhaecke T,De Paepe K,Rogiers V

更新日期：2014-01-01 00:00:00

abstract：:The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...

journal_title：Skin pharmacology and physiology

authors： Garcia-Peterson LM,Wilking-Busch MJ,Ndiaye MA,Philippe CGA,Setaluri V,Ahmad N

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Retinoic acid (RA) and benzoyl peroxide (BP) were studied, comparing their keratolytic efficacy and water barrier disruption to that of salicylic acid (SA), a well-established keratolytic, under similar conditions. PATIENTS/METHODS:Six volunteers were included in this blinded study. Eleven randomized test s...

journal_title：Skin pharmacology and physiology

authors： Waller JM,Dreher F,Behnam S,Ford C,Lee C,Tiet T,Weinstein GD,Maibach HI

更新日期：2006-01-01 00:00:00