What is sensitive skin? A systematic literature review of objective measurements.

abstract：:Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others i...

journal_title：Skin pharmacology and physiology

authors： Perumal O,Murthy SN,Kalia YN

更新日期：2013-01-01 00:00:00

abstract：:A therapeutic endpoint is a very important tool to evaluate response in clinical trials. In 2005, a consensus statement identified two late endpoints of disease activity in pemphigus: complete remission off therapy and complete remission on therapy, both definitions applying to patients without lesions for at least 2 ...

journal_title：Skin pharmacology and physiology

authors： Iranzo P,Pigem R,Giavedoni P,Alsina-Gibert M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cetuximab is a member of a new family of antineoplastic agents that inhibit the epidermal growth factor receptor (EGF-R), and which are increasingly being used in the treatment of solid tumors. METHODS:We have observed new secondary side effects. We present here 2 patients with acneiform eruption secondary ...

journal_title：Skin pharmacology and physiology

authors： Gencoglan G,Ceylan C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Research has revealed new insights into the pathogenesis of psoriasis, leading to new therapeutic options. So far the order of changes in the pathogenesis of psoriasis is unclear. The responses to cutaneous leukotriene B4 (LTB4) application have been studied in the past as an in vivo model for inflammation. ...

journal_title：Skin pharmacology and physiology

authors： Hendriks AG,Keijsers RR,Seyger MM,van de Kerkhof PC,van Erp PE

更新日期：2014-01-01 00:00:00

abstract：:Carotenoids could serve as marker substances of the antioxidant status of the human skin. In the present study, an optical skin scanner was used to analyse the carotenoid concentration obtained from 4 volunteers over a period of 13 days. The measurements were taken daily at different time points. In addition, the volu...

journal_title：Skin pharmacology and physiology

authors： Lademann J,Köcher W,Yu R,Meinke MC,Na Lee B,Jung S,Sterry W,Darvin ME

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Advanced glycation end products, which are linked to both aging and hyperglycemia, cause marked functional and structural alterations in human skin. Though it is well known that the metabolism of glucose is closely associated with that of fatty acid (FA), sharing the same energy-yielding reaction pathwa...

journal_title：Skin pharmacology and physiology

authors： Yokota M,Tokudome Y

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics and increased skin surface area exposure. METHODS:The ability of urea, a low molecular-weight h...

journal_title：Skin pharmacology and physiology

authors： Vieille-Petit A,Blickenstaff N,Coman G,Maibach H

更新日期：2015-01-01 00:00:00

abstract：:The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To 'tell time', most living organisms use internal timing mechanisms known as 'biological clocks'. These 'clocks' coordinate our physiological and behavioral functions and inte...

journal_title：Skin pharmacology and physiology

authors： Mehling A,Fluhr JW

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:The skin, as the outermost organ, protects against exogenous hazards (outside-in barrier) and prevents the loss of essential parts of the body (inside-out barrier). The epidermal barrier exerts several functions with specific morphological elements. Regional differences in skin functions are well known. ...

journal_title：Skin pharmacology and physiology

authors： Kleesz P,Darlenski R,Fluhr JW

更新日期：2012-01-01 00:00:00

abstract：:Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a co...

journal_title：Skin pharmacology and physiology

authors： Le Vu P,Takatori R,Iwamoto T,Akagi Y,Satsu H,Totsuka M,Chida K,Sato K,Shimizu M

更新日期：2015-01-01 00:00:00

abstract：:The aim of the study was to assess an Ectoin formulation with regard to the antiageing properties. The study was designed as a monocentric, randomized, double-blind application test, in order to ensure the compatibility and the efficacy of Ectoin in comparison to a vehicle emulsion. A total of 104 voluntary healthy fe...

journal_title：Skin pharmacology and physiology

authors： Heinrich U,Garbe B,Tronnier H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...

journal_title：Skin pharmacology and physiology

authors： Jacques-Jamin C,Duplan H,Rothe H,Vaillant O,Eilstein J,Grégoire S,Cubberley R,Lange D,Ellison C,Klaric M,Hewitt N,Schepky A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIM:Since the pharmacological effects of diclofenac (DF) are short-lived because of its short half-life, prolongation of the pharmacological effect in a topical formulation is needed for more appropriate clinical use. For the enhancement of dermal accumulation and prolongation of the pharmacological effe...

journal_title：Skin pharmacology and physiology

authors： Uchino T,Miyazaki Y,Ishikawa A,Kagawa Y

更新日期：2019-01-01 00:00:00

abstract：:The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...

journal_title：Skin pharmacology and physiology

authors： Garcia-Peterson LM,Wilking-Busch MJ,Ndiaye MA,Philippe CGA,Setaluri V,Ahmad N

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which ...

journal_title：Skin pharmacology and physiology

authors： Man MQ,Xin SJ,Song SP,Cho SY,Zhang XJ,Tu CX,Feingold KR,Elias PM

更新日期：2009-01-01 00:00:00

abstract：:To reduce pruritus and colonization with Staphylococcus aureus, textiles containing silver are increasingly used as therapeutic option for patients with atopic dermatitis (AD). While wearing such textiles, the contained silver is in close contact with the patient's skin. The silver serves two purposes: to reduce bacte...

journal_title：Skin pharmacology and physiology

authors： Daeschlein G,Assadian O,Arnold A,Haase H,Kramer A,Jünger M

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To use high-speed differential scanning calorimetry (DSC) in the identification of transitions in human stratum corneum (SC). Several scanning rates (100 degrees C/min to 400 degrees C/min) are used. RESULTS:Eight transitions from 0 to 120 degrees C are detected in a significant number of samples. Most of thes...

journal_title：Skin pharmacology and physiology

authors： Silva CL,Nunes SC,Eusébio ME,Pais AA,Sousa JJ

更新日期：2006-01-01 00:00:00

abstract：:In the present study, we evaluated the protective action of cream preparations containing seven different types of marigold and rosemary extracts in vivo in healthy volunteers with experimentally induced irritant contact dermatitis (ICD). Marigold and rosemary extracts in base cream DAC (Deutscher Arzneimittel-Codex =...

journal_title：Skin pharmacology and physiology

authors： Fuchs SM,Schliemann-Willers S,Fischer TW,Elsner P

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF THE STUDY:To investigate the role of paraoxonase 1 (PON1) and vitamin E in the pathogenesis of some autoimmune diseases, and to correlate their levels with the disease activity. PROCEDURES:This randomized case control study was performed on 60 subjects: 45 patients [suffering from psoriasis, vitiligo and al...

journal_title：Skin pharmacology and physiology

authors： Ramadan R,Tawdy A,Abdel Hay R,Rashed L,Tawfik D

更新日期：2013-01-01 00:00:00

abstract：:Talarozole is a new highly potent and selective azole derivative which inhibits cytochrome-P450-dependent all-trans-retinoic acid catabolism. It is in clinical development for the treatment of psoriasis and acne. However, no local pharmacokinetic data on the diffusion behaviour of talarozole in the skin itself are ava...

journal_title：Skin pharmacology and physiology

authors： Baert B,De Spiegeleer B

更新日期：2011-01-01 00:00:00

abstract：:Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and t...

journal_title：Skin pharmacology and physiology

authors： Kobayashi M,Kabashima K,Nakamura M,Tokura Y

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...

journal_title：Skin pharmacology and physiology

authors： Goto K,Hiramoto K,Kawakita M,Yamaoka M,Ooi K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect the skin from these insults. OBJECTIVE:The aim of this study was to determine the ex vivo ascorbic acid penetration and its degradation in the skin after its topical ap...

journal_title：Skin pharmacology and physiology

authors： Leveque N,Muret P,Makki S,Mac-Mary S,Kantelip JP,Humbert P

更新日期：2004-11-01 00:00:00

abstract：:In animal wound models, accelerated wound closure has been shown by use of polihexanide applied in antimicrobially effective concentrations. Additionally, an increased ATP production of keratinocytes in vitro induced by polihexanide was demonstrated and interpreted as a stimulatory effect on cell proliferation. Based ...

journal_title：Skin pharmacology and physiology

authors： Roth C,Beule AG,Kramer A,Hosemann W,Kohlmann T,Scharf C

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. OBJECTIVES:This work presents t...

journal_title：Skin pharmacology and physiology

authors： Bow JR,Sonoki Y,Uchiyama M,Shimizu E,Tanaka K,Dauskardt RH

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound heal...

journal_title：Skin pharmacology and physiology

authors： Park G,Oh DS,Kim YU,Park MK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The skin has become very attractive as a route for drug administration. Optimization of topical drug formulations by the addition of penetration enhancers may facilitate the passage of drugs through the stratum corneum. METHODS:In this paper, the skin penetration effect of phytosphingosine and 9 derive...

journal_title：Skin pharmacology and physiology

authors： Veryser L,Boonen J,Taevernier L,Guillaume J,Risseeuw M,Shah SN,Roche N,Van Calenbergh S,De Spiegeleer B

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. OBJECTIVE:We investigated the link between flare and itch using 3 models of itch. METHODS:Skin provocations with histamine, capsaicin, and cowha...

journal_title：Skin pharmacology and physiology

authors： Lehmann S,Deuring E,Weller K,Scheffel J,Metz M,Maurer M,Hawro T

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Polymethylmethacrylate (PMMA) plates generally used for the in vitro testing of sunscreens have failed to yield a satisfactory correlation between the sun protection factor (SPF) in vitro and that in vivo. In the present study, various polymers were investigated as alternative substrates to PMMA plates. PROCED...

journal_title：Skin pharmacology and physiology

authors： Sohn M,Malburet C,Baptiste L,Prigl Y

更新日期：2017-01-01 00:00:00

abstract：:In a clinical study, the skin penetration properties of melatonin 0.01% in a cream and 0.01 and 0.03% in a solution were investigated by evaluation of the serum melatonin levels over a 24-hour time course in 15 healthy volunteers. Blood samples for melatonin measurements were taken at 9.00 a.m. before applying the tes...

journal_title：Skin pharmacology and physiology

authors： Fischer TW,Greif C,Fluhr JW,Wigger-Alberti W,Elsner P

更新日期：2004-07-01 00:00:00