Abstract:
INTRODUCTION:Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. OBJECTIVE:We investigated the link between flare and itch using 3 models of itch. METHODS:Skin provocations with histamine, capsaicin, and cowhage were performed in 31 subjects. Itch was quantified using the visual analog scale. Flare was assessed using laser speckle contrast imaging (LSCI) and digital photography. RESULTS:The duration, intensity, and area under the curve of histamine-induced itch correlated with the area of increased blood flow measured with LSCI (r = 0.545, p = 0.002; r = 0.575, p = 0.001; and r = 0.649, p < 0.001, respectively). Itch and skin blood flow in response to capsaicin or cowhage did not correlate. CONCLUSION:In histamine-induced skin inflammation, itch and increased blood flow are linked. Thus, the area of histamine-induced flare may be used as a surrogate marker for histamine-induced itch.
journal_name
Skin Pharmacol Physioljournal_title
Skin pharmacology and physiologyauthors
Lehmann S,Deuring E,Weller K,Scheffel J,Metz M,Maurer M,Hawro Tdoi
10.1159/000508795subject
Has Abstractpub_date
2020-01-01 00:00:00pages
244-252issue
5eissn
1660-5527issn
1660-5535pii
000508795journal_volume
33pub_type
杂志文章abstract:BACKGROUND/AIMS:Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. S...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000477854
更新日期:2017-01-01 00:00:00
abstract::Carotenoids could serve as marker substances of the antioxidant status of the human skin. In the present study, an optical skin scanner was used to analyse the carotenoid concentration obtained from 4 volunteers over a period of 13 days. The measurements were taken daily at different time points. In addition, the volu...
journal_title:Skin pharmacology and physiology
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abstract:BACKGROUND:Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect the skin from these insults. OBJECTIVE:The aim of this study was to determine the ex vivo ascorbic acid penetration and its degradation in the skin after its topical ap...
journal_title:Skin pharmacology and physiology
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doi:10.1159/000081115
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000324053
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journal_title:Skin pharmacology and physiology
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doi:10.1159/000464471
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The use of antioxidants has become a common practice in the development of antiaging cosmetics. OBJECTIVE:The aim of this study was to evaluate the clinical efficacy of cosmetic formulations containing lycopene and melatonin antioxidants. METHOD:Thirty-six healthy women from 32 to 65 years were enrolled in...
journal_title:Skin pharmacology and physiology
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doi:10.1159/000508673
更新日期:2020-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000080217
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000488250
更新日期:2018-01-01 00:00:00
abstract::Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501734
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000362175
更新日期:2015-01-01 00:00:00
abstract::It is preferred that topically administered drugs act either dermally or transdermally. For that reason they have to penetrate into the deeper skin layers or permeate the skin. The outermost layer of the human skin, the stratum corneum, is responsible for its barrier function. Most topically administered drugs do not ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000091978
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363579
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available re...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000362740
更新日期:2015-01-01 00:00:00
abstract::Squalene is a major sebum lipid which is easily peroxidized by ultraviolet A (UVA) irradiation, generating products that can stress keratinocytes. Prevention of squalene photooxidation with antioxidants could potentially help defend skin from environmental stress. Previously, we have systematically characterized butyl...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501731
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000448121
更新日期:2016-01-01 00:00:00
abstract::A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antiox...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000109084
更新日期:2008-01-01 00:00:00
abstract::Talarozole is a new highly potent and selective azole derivative which inhibits cytochrome-P450-dependent all-trans-retinoic acid catabolism. It is in clinical development for the treatment of psoriasis and acne. However, no local pharmacokinetic data on the diffusion behaviour of talarozole in the skin itself are ava...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000323012
更新日期:2011-01-01 00:00:00
abstract::In animal wound models, accelerated wound closure has been shown by use of polihexanide applied in antimicrobially effective concentrations. Additionally, an increased ATP production of keratinocytes in vitro induced by polihexanide was demonstrated and interpreted as a stimulatory effect on cell proliferation. Based ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000319602
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abstract::Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000363149
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. METHODS:Thirty women (age 20-52 years) were r...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000235552
更新日期:2009-01-01 00:00:00
abstract::Along with antibiotics, antihistamines are the most widely used systemic drugs in dermatology. This is attributable to the major role played by histamine in common diseases such as urticaria and atopic eczema. Of the currently recognised four subtypes of G protein-coupled histamine receptors, only the H1 and H2 subtyp...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000086667
更新日期:2005-09-01 00:00:00
abstract::In a clinical study, the skin penetration properties of melatonin 0.01% in a cream and 0.01 and 0.03% in a solution were investigated by evaluation of the serum melatonin levels over a 24-hour time course in 15 healthy volunteers. Blood samples for melatonin measurements were taken at 9.00 a.m. before applying the tes...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000078822
更新日期:2004-07-01 00:00:00
abstract::Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most c...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000479529
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To use high-speed differential scanning calorimetry (DSC) in the identification of transitions in human stratum corneum (SC). Several scanning rates (100 degrees C/min to 400 degrees C/min) are used. RESULTS:Eight transitions from 0 to 120 degrees C are detected in a significant number of samples. Most of thes...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000092593
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Acrolein is a degradation product of lipid peroxide as well as a well-known environmental pollutant. As a hallmark of oxidatively damaged protein, protein carbonyl, including acrolein-protein adduct, has been observed in the skin. However, the influence of protein carbonylation on the stratum corneum (SC) ha...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000148042
更新日期:2008-01-01 00:00:00
abstract::Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and t...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000183924
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Retinoic acid (RA) and benzoyl peroxide (BP) were studied, comparing their keratolytic efficacy and water barrier disruption to that of salicylic acid (SA), a well-established keratolytic, under similar conditions. PATIENTS/METHODS:Six volunteers were included in this blinded study. Eleven randomized test s...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000093984
更新日期:2006-01-01 00:00:00
abstract::The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4-7 were applied in patch ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501976
更新日期:2019-01-01 00:00:00