Abstract:
BACKGROUND:Research has revealed new insights into the pathogenesis of psoriasis, leading to new therapeutic options. So far the order of changes in the pathogenesis of psoriasis is unclear. The responses to cutaneous leukotriene B4 (LTB4) application have been studied in the past as an in vivo model for inflammation. The aim of the present study is to find out the order of changes of key steps in inflammation, which all have been shown to be involved in mature psoriatic lesions. OBJECTIVE:To study the dynamics of the consecutive stages of inflammation in challenged skin as a reflection of a psoriasis-like inflammatory response. METHODS:We examined the dynamics of epidermal growth control and the key representatives of the innate and acquired immune system during the first 72 h after challenging the skin by LTB4 application. RESULTS:Interleukin 17-positive (IL-17+) cells dominate the acute phase of inflammation, whereas T-Bet+ cells seem to increase gradually during the entire observation period. This indicates a more important role for IL-17 in the unstable phase of inflammation and a more prominent role for T-Bet+ cells within the chronic phase. CONCLUSION:The present model is highly reproducible and is useful in studying the dynamics of a psoriasis-like inflammation with respect to key components of immunity. It could provide a useful tool to study the immediate biological effects of new therapies like anti-IL-17 drugs on IL-17 production and effects on cutaneous inflammation and epidermal proliferation in vivo.
journal_name
Skin Pharmacol Physioljournal_title
Skin pharmacology and physiologyauthors
Hendriks AG,Keijsers RR,Seyger MM,van de Kerkhof PC,van Erp PEdoi
10.1159/000354119subject
Has Abstractpub_date
2014-01-01 00:00:00pages
120-6issue
3eissn
1660-5527issn
1660-5535pii
000354119journal_volume
27pub_type
临床试验,杂志文章abstract::The aim of the study was to examine the effectiveness of the oxidized form of nicotinamide adenine dinucleotide (NAD(+)), adenosine precursor, in 37 patients suffering from psoriasis. As NAD(+) is known to be relatively unstable, the second goal was to establish the proper conditions for the satisfactory stability of ...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000096170
更新日期:2007-01-01 00:00:00
abstract::Along with antibiotics, antihistamines are the most widely used systemic drugs in dermatology. This is attributable to the major role played by histamine in common diseases such as urticaria and atopic eczema. Of the currently recognised four subtypes of G protein-coupled histamine receptors, only the H1 and H2 subtyp...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000086667
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000231524
更新日期:2009-01-01 00:00:00
abstract::The aim of the study was to assess an Ectoin formulation with regard to the antiageing properties. The study was designed as a monocentric, randomized, double-blind application test, in order to ensure the compatibility and the efficacy of Ectoin in comparison to a vehicle emulsion. A total of 104 voluntary healthy fe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000103204
更新日期:2007-01-01 00:00:00
abstract::Combined ATR-FTIR (attenuated total reflection-Fourier transform infrared) spectroscopy and tape-stripping experiments in vitro on porcine ear skin were used to investigate the spatial distribution of different surfactants in the stratum corneum (SC). To reveal a possible connection between the size of the formed mice...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000368444
更新日期:2015-01-01 00:00:00
abstract::Solid lipid nanoparticles (SLNs) can enhance drug penetration into the skin, yet the mechanism of the improved transport is not known in full. To unravel the influence of the drug-particle interaction on penetration enhancement, 3 glucocorticoids (GCs), prednisolone (PD), the diester prednicarbate (PC) and the monoest...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000324053
更新日期:2011-01-01 00:00:00
abstract::A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antiox...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000109084
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. METHODS:Fifty-seven healthy full-term neonates aged < or = 48 h were randomly as...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000235552
更新日期:2009-01-01 00:00:00
abstract::Histone deacetylase inhibitors (HDACi), a relatively new group of epigenetic agents, are being investigated as powerful chemotherapeutics because of their antiproliferative and prodifferentiation effects both in vitro and in vivo, in various tumor cell lines. Only little is known with respect to their effects on norma...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000351363
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES/AIMS:The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied. For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes >1 microm and 3 nano-emulsions with droplet sizes <100 nm) were tested....
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000106076
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. METHODS:C...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000455237
更新日期:2017-01-01 00:00:00
abstract::Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others i...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000351815
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound heal...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000447016
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. S...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000477854
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Keloids result from aberrations in the normal wound healing cascade and can lead to pruritus, contractures and pain. The underlying mechanisms of excessive scarring are not yet understood, and most therapeutic strategies remain unsatisfactory. Psoriasin (S100A7) and koebnerisin (S100A15) are released by...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363579
更新日期:2015-01-01 00:00:00
abstract::In animal wound models, accelerated wound closure has been shown by use of polihexanide applied in antimicrobially effective concentrations. Additionally, an increased ATP production of keratinocytes in vitro induced by polihexanide was demonstrated and interpreted as a stimulatory effect on cell proliferation. Based ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000319602
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000475472
更新日期:2017-01-01 00:00:00
abstract::The investigation of drug penetration into the stratum corneum (SC) by tape-stripping requires an accurate measure of the amount of SC on each tape-strip in order to determine the depth inside the SC. This study applies infrared densitometry (IR-D) to in vitro tape-stripping using the novel Squame Scan(R) 850A. The de...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000288165
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics and increased skin surface area exposure. METHODS:The ability of urea, a low molecular-weight h...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363148
更新日期:2015-01-01 00:00:00
abstract::The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To 'tell time', most living organisms use internal timing mechanisms known as 'biological clocks'. These 'clocks' coordinate our physiological and behavioral functions and inte...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000093113
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:The skin has become very attractive as a route for drug administration. Optimization of topical drug formulations by the addition of penetration enhancers may facilitate the passage of drugs through the stratum corneum. METHODS:In this paper, the skin penetration effect of phytosphingosine and 9 derive...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000365730
更新日期:2015-01-01 00:00:00
abstract::Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000363149
更新日期:2015-01-01 00:00:00
abstract::Biogenic amines are potential irritants e.g. in fish-, meat-, milk- and egg-processing professions like cooks, butchers and bakers. The aim of this study was to test the irritative and barrier-disrupting properties of the biogenic amines ammonium hydroxide (AM), dimethylamine (DMA) and trimethylamine (TMA). A repeated...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000083709
更新日期:2005-03-01 00:00:00
abstract::Talarozole is a new highly potent and selective azole derivative which inhibits cytochrome-P450-dependent all-trans-retinoic acid catabolism. It is in clinical development for the treatment of psoriasis and acne. However, no local pharmacokinetic data on the diffusion behaviour of talarozole in the skin itself are ava...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000323012
更新日期:2011-01-01 00:00:00
abstract::In a clinical study, the skin penetration properties of melatonin 0.01% in a cream and 0.01 and 0.03% in a solution were investigated by evaluation of the serum melatonin levels over a 24-hour time course in 15 healthy volunteers. Blood samples for melatonin measurements were taken at 9.00 a.m. before applying the tes...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000078822
更新日期:2004-07-01 00:00:00
abstract::Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a co...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000369830
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Polymethylmethacrylate (PMMA) plates generally used for the in vitro testing of sunscreens have failed to yield a satisfactory correlation between the sun protection factor (SPF) in vitro and that in vivo. In the present study, various polymers were investigated as alternative substrates to PMMA plates. PROCED...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000464471
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND AIM:Since the pharmacological effects of diclofenac (DF) are short-lived because of its short half-life, prolongation of the pharmacological effect in a topical formulation is needed for more appropriate clinical use. For the enhancement of dermal accumulation and prolongation of the pharmacological effe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501734
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. OBJECTIVES:This work presents t...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000507456
更新日期:2020-01-01 00:00:00
abstract::Brian Barry published over 300 research articles across topics ranging from colloid science, vasoconstriction and the importance of thermodynamics in dermal drug delivery to exploring the structure and organisation of the stratum corneum barrier lipids and numerous strategies for improving topical and transdermal drug...
journal_title:Skin pharmacology and physiology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000351946
更新日期:2013-01-01 00:00:00