Sirtuins in Skin and Skin Cancers.

Abstract:

:The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases. Based on the available literature, the sirtuins appear to be important targets in the management of a variety of skin diseases from cosmetic (e.g., skin aging) to fatal conditions (e.g., melanoma).

journal_name

Skin Pharmacol Physiol

authors

Garcia-Peterson LM,Wilking-Busch MJ,Ndiaye MA,Philippe CGA,Setaluri V,Ahmad N

doi

10.1159/000477417

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

216-224

issue

4

eissn

1660-5527

issn

1660-5535

pii

000477417

journal_volume

30

pub_type

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