Two cases of acneiform eruption induced by inhibitor of epidermal growth factor receptor.

Abstract:

BACKGROUND:Cetuximab is a member of a new family of antineoplastic agents that inhibit the epidermal growth factor receptor (EGF-R), and which are increasingly being used in the treatment of solid tumors. METHODS:We have observed new secondary side effects. We present here 2 patients with acneiform eruption secondary to the administration of cetuximab (IMC-C225, Erbitux). The diagnoses of these patients were adenocarcinoma. RESULTS:Histologically, a superficial purulent folliculitis and disordered differentiation with focal parakeratosis were observed. The follicular eruption responded favorably to treatment with 5% benzoyl peroxide and 4% erythromycin gel. These lesions healed within a few days after treatment. CONCLUSION:The cutaneous adverse effects of cetuximab are similar to other EGF-R-targeted agents and result from direct interference with the functions of EGF-R signaling in the skin.

journal_name

Skin Pharmacol Physiol

authors

Gencoglan G,Ceylan C

doi

10.1159/000106075

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

260-2

issue

5

eissn

1660-5527

issn

1660-5535

pii

000106075

journal_volume

20

pub_type

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