Turning theory into practice: the development of modern transdermal drug delivery systems and future trends.

Abstract:

:Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others in the 1960s helped to explain the processes involved in passive percutaneous absorption and led to the development of mathematical models to describe transdermal drug delivery. The intervening years have seen these theories turned to practice and a significant number of transdermal systems are now available including some that employ active drug delivery. This review briefly discusses the evolution of transdermal therapeutic systems over the years and the potential of newer transdermal technologies to deliver hydrophilic drugs and macromolecules through the skin.

journal_name

Skin Pharmacol Physiol

authors

Perumal O,Murthy SN,Kalia YN

doi

10.1159/000351815

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

331-42

issue

4-6

eissn

1660-5527

issn

1660-5535

pii

000351815

journal_volume

26

pub_type

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