Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa.

abstract：PURPOSE:To use high-speed differential scanning calorimetry (DSC) in the identification of transitions in human stratum corneum (SC). Several scanning rates (100 degrees C/min to 400 degrees C/min) are used. RESULTS:Eight transitions from 0 to 120 degrees C are detected in a significant number of samples. Most of thes...

journal_title：Skin pharmacology and physiology

authors： Silva CL,Nunes SC,Eusébio ME,Pais AA,Sousa JJ

更新日期：2006-01-01 00:00:00

abstract：:Cutaneous irritation presents a major health problem with serious social and occupational impact. The interaction between an irritant and the human skin depends on multiple factors: the intrinsic properties and the nature of the irritant itself, and specific individual- and environment-related variables. The main path...

journal_title：Skin pharmacology and physiology

authors： Fluhr JW,Darlenski R,Angelova-Fischer I,Tsankov N,Basketter D

更新日期：2008-01-01 00:00:00

abstract：AIM AND METHODS:Drug development in dermatotherapy and also development of transdermal therapeutic systems (TTS) demand high-predictive in vitro models to estimate drug levels in skin and systemic uptake. Here we compare three ready-to-use models, reconstructed human epidermis, split porcine skin and the perfused porci...

journal_title：Skin pharmacology and physiology

authors： Mahmoud A,Haberland A,Dürrfeld M,Heydeck D,Wagner S,Schafer-Korting M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics and increased skin surface area exposure. METHODS:The ability of urea, a low molecular-weight h...

journal_title：Skin pharmacology and physiology

authors： Vieille-Petit A,Blickenstaff N,Coman G,Maibach H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound heal...

journal_title：Skin pharmacology and physiology

authors： Park G,Oh DS,Kim YU,Park MK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The use of antioxidants has become a common practice in the development of antiaging cosmetics. OBJECTIVE:The aim of this study was to evaluate the clinical efficacy of cosmetic formulations containing lycopene and melatonin antioxidants. METHOD:Thirty-six healthy women from 32 to 65 years were enrolled in...

journal_title：Skin pharmacology and physiology

authors： Marchena AM,Franco L,Romero AM,Barriga C,Rodríguez AB

更新日期：2020-01-01 00:00:00

abstract：:Biogenic amines are potential irritants e.g. in fish-, meat-, milk- and egg-processing professions like cooks, butchers and bakers. The aim of this study was to test the irritative and barrier-disrupting properties of the biogenic amines ammonium hydroxide (AM), dimethylamine (DMA) and trimethylamine (TMA). A repeated...

journal_title：Skin pharmacology and physiology

authors： Fluhr JW,Kelterer D,Fuchs S,Kaatz M,Grieshaber R,Kleesz P,Elsner P

更新日期：2005-03-01 00:00:00

abstract：:The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4-7 were applied in patch ...

journal_title：Skin pharmacology and physiology

authors： Proksch E,Soeberdt M,Neumann C,Kilic A,Reich H,Abels C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which ...

journal_title：Skin pharmacology and physiology

authors： Man MQ,Xin SJ,Song SP,Cho SY,Zhang XJ,Tu CX,Feingold KR,Elias PM

更新日期：2009-01-01 00:00:00

abstract：:Squalene is a major sebum lipid which is easily peroxidized by ultraviolet A (UVA) irradiation, generating products that can stress keratinocytes. Prevention of squalene photooxidation with antioxidants could potentially help defend skin from environmental stress. Previously, we have systematically characterized butyl...

journal_title：Skin pharmacology and physiology

authors： Zhou D,Weng X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:About 50% of the sun's radiation arriving on earth is visible light (VIS). For a long time, its effects on human health have not been fully investigated. But recently, the influence of VIS has gained more attention, especially regarding skin physiology. Studies showed various effects, many of them harmful, c...

journal_title：Skin pharmacology and physiology

authors： Wabnik M,Kockott D,Garbe B,Theek C,Heinrich U,Tronnier H,Braun N

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available re...

journal_title：Skin pharmacology and physiology

authors： Wohlrab J,Neubert RH,Heskamp ML,Michael J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. OBJECTIVES:This work presents t...

journal_title：Skin pharmacology and physiology

authors： Bow JR,Sonoki Y,Uchiyama M,Shimizu E,Tanaka K,Dauskardt RH

更新日期：2020-01-01 00:00:00

abstract：:In the present study, we evaluated the protective action of cream preparations containing seven different types of marigold and rosemary extracts in vivo in healthy volunteers with experimentally induced irritant contact dermatitis (ICD). Marigold and rosemary extracts in base cream DAC (Deutscher Arzneimittel-Codex =...

journal_title：Skin pharmacology and physiology

authors： Fuchs SM,Schliemann-Willers S,Fischer TW,Elsner P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. METHODS:Thirty women (age 20-52 years) were r...

journal_title：Skin pharmacology and physiology

authors： Srivilai J,Nontakhot K,Nutuan T,Waranuch N,Khorana N,Wisuthiprot W,Scholfield CN,Champachaisri K,Ingkaninan K

更新日期：2018-01-01 00:00:00

abstract：:Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous...

journal_title：Skin pharmacology and physiology

authors： Wohlrab J,Neubert RH,Sommer E,Michael J

更新日期：2016-01-01 00:00:00

abstract：:In the present study, we investigated the effects of tomato extract (TE) containing lycopene and palm fruit extract (PE) rich in carotenoids on the growth and pigmentation of melanocyte cultures of Caucasian origin. The extracts were tested at different concentrations and in combination with vitamins E and C. Melanocy...

journal_title：Skin pharmacology and physiology

authors： Smit N,Vicanova J,Cramers P,Vrolijk H,Pavel S

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...

journal_title：Skin pharmacology and physiology

authors： Jacques-Jamin C,Duplan H,Rothe H,Vaillant O,Eilstein J,Grégoire S,Cubberley R,Lange D,Ellison C,Klaric M,Hewitt N,Schepky A

更新日期：2017-01-01 00:00:00

abstract：:Along with antibiotics, antihistamines are the most widely used systemic drugs in dermatology. This is attributable to the major role played by histamine in common diseases such as urticaria and atopic eczema. Of the currently recognised four subtypes of G protein-coupled histamine receptors, only the H1 and H2 subtyp...

journal_title：Skin pharmacology and physiology

authors： Greaves MW

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES/AIMS:The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied. For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes >1 microm and 3 nano-emulsions with droplet sizes <100 nm) were tested....

journal_title：Skin pharmacology and physiology

authors： Izquierdo P,Wiechers JW,Escribano E,García-Celma MJ,Tadros TF,Esquena J,Dederen JC,Solans C

更新日期：2007-01-01 00:00:00

abstract：:The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To 'tell time', most living organisms use internal timing mechanisms known as 'biological clocks'. These 'clocks' coordinate our physiological and behavioral functions and inte...

journal_title：Skin pharmacology and physiology

authors： Mehling A,Fluhr JW

更新日期：2006-01-01 00:00:00

abstract：:The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...

journal_title：Skin pharmacology and physiology

authors： Garcia-Peterson LM,Wilking-Busch MJ,Ndiaye MA,Philippe CGA,Setaluri V,Ahmad N

更新日期：2017-01-01 00:00:00

abstract：:The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal o...

journal_title：Skin pharmacology and physiology

authors： Behm B,Kemper M,Babilas P,Abels C,Schreml S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Research has revealed new insights into the pathogenesis of psoriasis, leading to new therapeutic options. So far the order of changes in the pathogenesis of psoriasis is unclear. The responses to cutaneous leukotriene B4 (LTB4) application have been studied in the past as an in vivo model for inflammation. ...

journal_title：Skin pharmacology and physiology

authors： Hendriks AG,Keijsers RR,Seyger MM,van de Kerkhof PC,van Erp PE

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Advanced glycation end products, which are linked to both aging and hyperglycemia, cause marked functional and structural alterations in human skin. Though it is well known that the metabolism of glucose is closely associated with that of fatty acid (FA), sharing the same energy-yielding reaction pathwa...

journal_title：Skin pharmacology and physiology

authors： Yokota M,Tokudome Y

更新日期：2016-01-01 00:00:00

abstract：:The aim of the study was to examine the effectiveness of the oxidized form of nicotinamide adenine dinucleotide (NAD(+)), adenosine precursor, in 37 patients suffering from psoriasis. As NAD(+) is known to be relatively unstable, the second goal was to establish the proper conditions for the satisfactory stability of ...

journal_title：Skin pharmacology and physiology

authors： Wozniacka A,Szajerski P,Adamus J,Gebicki J,Sysa-Jedrzejowska A

更新日期：2007-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi), a relatively new group of epigenetic agents, are being investigated as powerful chemotherapeutics because of their antiproliferative and prodifferentiation effects both in vitro and in vivo, in various tumor cell lines. Only little is known with respect to their effects on norma...

journal_title：Skin pharmacology and physiology

authors： Lemper M,Snykers S,Vanhaecke T,De Paepe K,Rogiers V

更新日期：2014-01-01 00:00:00

abstract：:Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and t...

journal_title：Skin pharmacology and physiology

authors： Kobayashi M,Kabashima K,Nakamura M,Tokura Y

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches are needed to reduce the burden of AD and corticosteroid usage in infants. METHODS:The once-daily consumption of heat-treated probiotic Lactobacillus...

journal_title：Skin pharmacology and physiology

authors： Yan DC,Hung CH,Sy LB,Lue KH,Shih IH,Yang CY,Chen LC,Sun HL,Lee MS,Chambard J,Tanguy J,Hughes-Formella B,Nutten S,Blanchard C

更新日期：2019-01-01 00:00:00

abstract：:Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a co...

journal_title：Skin pharmacology and physiology

authors： Le Vu P,Takatori R,Iwamoto T,Akagi Y,Satsu H,Totsuka M,Chida K,Sato K,Shimizu M

更新日期：2015-01-01 00:00:00