Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH.

Abstract:

:The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.

journal_name

Skin Pharmacol Physiol

authors

Behm B,Kemper M,Babilas P,Abels C,Schreml S

doi

10.1159/000439030

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

290-5

issue

6

eissn

1660-5527

issn

1660-5535

pii

000439030

journal_volume

28

pub_type

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