Abstract:
:The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.
journal_name
Skin Pharmacol Physioljournal_title
Skin pharmacology and physiologyauthors
Behm B,Kemper M,Babilas P,Abels C,Schreml Sdoi
10.1159/000439030subject
Has Abstractpub_date
2015-01-01 00:00:00pages
290-5issue
6eissn
1660-5527issn
1660-5535pii
000439030journal_volume
28pub_type
杂志文章,随机对照试验abstract::The objective of the present investigation was to examine the utilization of optical and spectroscopic methods for the noninvasive characterization of Anthelios XL Fluide Extreme (SPF 50+), an exemplary sunscreen, concerning its homogeneity of distribution on the skin, its spectroscopic properties and its overall prot...
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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journal_title:Skin pharmacology and physiology
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