Current status of healthy human skin models: can histone deacetylase inhibitors potentially improve the present replacement models?

abstract：:A therapeutic endpoint is a very important tool to evaluate response in clinical trials. In 2005, a consensus statement identified two late endpoints of disease activity in pemphigus: complete remission off therapy and complete remission on therapy, both definitions applying to patients without lesions for at least 2 ...

journal_title：Skin pharmacology and physiology

authors： Iranzo P,Pigem R,Giavedoni P,Alsina-Gibert M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which ...

journal_title：Skin pharmacology and physiology

authors： Man MQ,Xin SJ,Song SP,Cho SY,Zhang XJ,Tu CX,Feingold KR,Elias PM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:About 50% of the sun's radiation arriving on earth is visible light (VIS). For a long time, its effects on human health have not been fully investigated. But recently, the influence of VIS has gained more attention, especially regarding skin physiology. Studies showed various effects, many of them harmful, c...

journal_title：Skin pharmacology and physiology

authors： Wabnik M,Kockott D,Garbe B,Theek C,Heinrich U,Tronnier H,Braun N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...

journal_title：Skin pharmacology and physiology

authors： Goto K,Hiramoto K,Kawakita M,Yamaoka M,Ooi K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect the skin from these insults. OBJECTIVE:The aim of this study was to determine the ex vivo ascorbic acid penetration and its degradation in the skin after its topical ap...

journal_title：Skin pharmacology and physiology

authors： Leveque N,Muret P,Makki S,Mac-Mary S,Kantelip JP,Humbert P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:The vitamin D endocrine system, besides multiple other functions, regulates aging in many tissues, including the skin. It protects the skin against the hazardous effects of many skin age-inducing agents, including ultraviolet radiation. Thus, in the present study we aimed to investigate the relationship betw...

journal_title：Skin pharmacology and physiology

authors： Dawoud NM,Bakry OA,Shoeib MA,Ismael HN

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Polymethylmethacrylate (PMMA) plates generally used for the in vitro testing of sunscreens have failed to yield a satisfactory correlation between the sun protection factor (SPF) in vitro and that in vivo. In the present study, various polymers were investigated as alternative substrates to PMMA plates. PROCED...

journal_title：Skin pharmacology and physiology

authors： Sohn M,Malburet C,Baptiste L,Prigl Y

更新日期：2017-01-01 00:00:00

abstract：:Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and t...

journal_title：Skin pharmacology and physiology

authors： Kobayashi M,Kabashima K,Nakamura M,Tokura Y

更新日期：2009-01-01 00:00:00

abstract：:To reduce pruritus and colonization with Staphylococcus aureus, textiles containing silver are increasingly used as therapeutic option for patients with atopic dermatitis (AD). While wearing such textiles, the contained silver is in close contact with the patient's skin. The silver serves two purposes: to reduce bacte...

journal_title：Skin pharmacology and physiology

authors： Daeschlein G,Assadian O,Arnold A,Haase H,Kramer A,Jünger M

更新日期：2010-01-01 00:00:00

abstract：AIM:The purpose of this study was to characterise C₆₀-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. METHODS:Dispersions were characterised according to their pH, particle size, zeta p...

journal_title：Skin pharmacology and physiology

authors： Souto GD,Pohlmann AR,Guterres SS

更新日期：2015-01-01 00:00:00

abstract：:Combined ATR-FTIR (attenuated total reflection-Fourier transform infrared) spectroscopy and tape-stripping experiments in vitro on porcine ear skin were used to investigate the spatial distribution of different surfactants in the stratum corneum (SC). To reveal a possible connection between the size of the formed mice...

journal_title：Skin pharmacology and physiology

authors： Hoppel M,Holper E,Baurecht D,Valenta C

更新日期：2015-01-01 00:00:00

abstract：:Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...

journal_title：Skin pharmacology and physiology

authors： Richters R,Falcone D,Uzunbajakava N,Verkruysse W,van Erp P,van de Kerkhof P

更新日期：2015-01-01 00:00:00

abstract：:Talarozole is a new highly potent and selective azole derivative which inhibits cytochrome-P450-dependent all-trans-retinoic acid catabolism. It is in clinical development for the treatment of psoriasis and acne. However, no local pharmacokinetic data on the diffusion behaviour of talarozole in the skin itself are ava...

journal_title：Skin pharmacology and physiology

authors： Baert B,De Spiegeleer B

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches are needed to reduce the burden of AD and corticosteroid usage in infants. METHODS:The once-daily consumption of heat-treated probiotic Lactobacillus...

journal_title：Skin pharmacology and physiology

authors： Yan DC,Hung CH,Sy LB,Lue KH,Shih IH,Yang CY,Chen LC,Sun HL,Lee MS,Chambard J,Tanguy J,Hughes-Formella B,Nutten S,Blanchard C

更新日期：2019-01-01 00:00:00

abstract：:Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others i...

journal_title：Skin pharmacology and physiology

authors： Perumal O,Murthy SN,Kalia YN

更新日期：2013-01-01 00:00:00

abstract：:The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To 'tell time', most living organisms use internal timing mechanisms known as 'biological clocks'. These 'clocks' coordinate our physiological and behavioral functions and inte...

journal_title：Skin pharmacology and physiology

authors： Mehling A,Fluhr JW

更新日期：2006-01-01 00:00:00

abstract：:In the present study, we evaluated the protective action of cream preparations containing seven different types of marigold and rosemary extracts in vivo in healthy volunteers with experimentally induced irritant contact dermatitis (ICD). Marigold and rosemary extracts in base cream DAC (Deutscher Arzneimittel-Codex =...

journal_title：Skin pharmacology and physiology

authors： Fuchs SM,Schliemann-Willers S,Fischer TW,Elsner P

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To use high-speed differential scanning calorimetry (DSC) in the identification of transitions in human stratum corneum (SC). Several scanning rates (100 degrees C/min to 400 degrees C/min) are used. RESULTS:Eight transitions from 0 to 120 degrees C are detected in a significant number of samples. Most of thes...

journal_title：Skin pharmacology and physiology

authors： Silva CL,Nunes SC,Eusébio ME,Pais AA,Sousa JJ

更新日期：2006-01-01 00:00:00

abstract：:Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most c...

journal_title：Skin pharmacology and physiology

authors： Fernandes AR,Santos AC,Sanchez-Lopez E,Kovačević AB,Espina M,Calpena AC,Veiga FJ,Garcia ML,Souto EB

更新日期：2018-01-01 00:00:00

abstract：:Carotenoids could serve as marker substances of the antioxidant status of the human skin. In the present study, an optical skin scanner was used to analyse the carotenoid concentration obtained from 4 volunteers over a period of 13 days. The measurements were taken daily at different time points. In addition, the volu...

journal_title：Skin pharmacology and physiology

authors： Lademann J,Köcher W,Yu R,Meinke MC,Na Lee B,Jung S,Sterry W,Darvin ME

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. METHODS:Fifty-seven healthy full-term neonates aged < or = 48 h were randomly as...

journal_title：Skin pharmacology and physiology

authors： Garcia Bartels N,Mleczko A,Schink T,Proquitté H,Wauer RR,Blume-Peytavi U

更新日期：2009-01-01 00:00:00

abstract：:A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antiox...

journal_title：Skin pharmacology and physiology

authors： Brieva A,Philips N,Tejedor R,Guerrero A,Pivel JP,Alonso-Lebrero JL,Gonzalez S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. S...

journal_title：Skin pharmacology and physiology

authors： Czekalla C,Schönborn KH,Döge N,Jung S,Darvin ME,Lademann J,Meinke MC

更新日期：2017-01-01 00:00:00

abstract：:In the present study, we investigated the effects of tomato extract (TE) containing lycopene and palm fruit extract (PE) rich in carotenoids on the growth and pigmentation of melanocyte cultures of Caucasian origin. The extracts were tested at different concentrations and in combination with vitamins E and C. Melanocy...

journal_title：Skin pharmacology and physiology

authors： Smit N,Vicanova J,Cramers P,Vrolijk H,Pavel S

更新日期：2004-09-01 00:00:00

abstract：:The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4-7 were applied in patch ...

journal_title：Skin pharmacology and physiology

authors： Proksch E,Soeberdt M,Neumann C,Kilic A,Reich H,Abels C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:The skin, as the outermost organ, protects against exogenous hazards (outside-in barrier) and prevents the loss of essential parts of the body (inside-out barrier). The epidermal barrier exerts several functions with specific morphological elements. Regional differences in skin functions are well known. ...

journal_title：Skin pharmacology and physiology

authors： Kleesz P,Darlenski R,Fluhr JW

更新日期：2012-01-01 00:00:00

abstract：:In a clinical study, the skin penetration properties of melatonin 0.01% in a cream and 0.01 and 0.03% in a solution were investigated by evaluation of the serum melatonin levels over a 24-hour time course in 15 healthy volunteers. Blood samples for melatonin measurements were taken at 9.00 a.m. before applying the tes...

journal_title：Skin pharmacology and physiology

authors： Fischer TW,Greif C,Fluhr JW,Wigger-Alberti W,Elsner P

更新日期：2004-07-01 00:00:00

abstract：:It is preferred that topically administered drugs act either dermally or transdermally. For that reason they have to penetrate into the deeper skin layers or permeate the skin. The outermost layer of the human skin, the stratum corneum, is responsible for its barrier function. Most topically administered drugs do not ...

journal_title：Skin pharmacology and physiology

authors： Trommer H,Neubert RH

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND AIM:Since the pharmacological effects of diclofenac (DF) are short-lived because of its short half-life, prolongation of the pharmacological effect in a topical formulation is needed for more appropriate clinical use. For the enhancement of dermal accumulation and prolongation of the pharmacological effe...

journal_title：Skin pharmacology and physiology

authors： Uchino T,Miyazaki Y,Ishikawa A,Kagawa Y

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Keloids result from aberrations in the normal wound healing cascade and can lead to pruritus, contractures and pain. The underlying mechanisms of excessive scarring are not yet understood, and most therapeutic strategies remain unsatisfactory. Psoriasin (S100A7) and koebnerisin (S100A15) are released by...

journal_title：Skin pharmacology and physiology

authors： Gauglitz GG,Bureik D,Zwicker S,Ruzicka T,Wolf R

更新日期：2015-01-01 00:00:00