Abstract:
BACKGROUND/AIMS:Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches are needed to reduce the burden of AD and corticosteroid usage in infants. METHODS:The once-daily consumption of heat-treated probiotic Lactobacillus paracasei GM-080 or placebo for 16 weeks as supplementary approach to topical treatment with fluticasone propionate cream was compared in AD infants aged 4-30 months. Outcomes were SCORAD and its subscores, TEWL, Infants' Dermatitis Quality of Life Index (IDQOL), corticoid "sparing effect," CCL17/TARC, and IgE status. RESULTS:SCORAD, objective SCORAD, itching, and IDQOL decreased significantly (p < 0.001) over the treatment period in both treatment groups. Slight decreases (ns) were noted in TEWL in lesional and unaffected skin and CCL17 levels. There were no differences between the treatment groups. Total IgE increased over the treatment period in both groups, with significantly higher increase in the heat-treated probiotic group (p = 0.038). There was no evidence of a corticoid "sparing effect" by the probiotic. CONCLUSIONS:In this design, the probiotic L. paracasei was not beneficial as a complementary approach to topical corticosteroids in infants with AD. However, slight beneficial effects may have been masked by the moderate potency corticoid.
journal_name
Skin Pharmacol Physioljournal_title
Skin pharmacology and physiologyauthors
Yan DC,Hung CH,Sy LB,Lue KH,Shih IH,Yang CY,Chen LC,Sun HL,Lee MS,Chambard J,Tanguy J,Hughes-Formella B,Nutten S,Blanchard Cdoi
10.1159/000499436subject
Has Abstractpub_date
2019-01-01 00:00:00pages
201-211issue
4eissn
1660-5527issn
1660-5535pii
000499436journal_volume
32pub_type
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000362175
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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pub_type: 杂志文章,随机对照试验
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000369830
更新日期:2015-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Skin pharmacology and physiology
pub_type: 传,历史文章,杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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