Influence of different cosmetic formulations on the human skin barrier.

abstract：BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...

journal_title：Skin pharmacology and physiology

authors： Goto K,Hiramoto K,Kawakita M,Yamaoka M,Ooi K

更新日期：2018-01-01 00:00:00

abstract：:Combined ATR-FTIR (attenuated total reflection-Fourier transform infrared) spectroscopy and tape-stripping experiments in vitro on porcine ear skin were used to investigate the spatial distribution of different surfactants in the stratum corneum (SC). To reveal a possible connection between the size of the formed mice...

journal_title：Skin pharmacology and physiology

authors： Hoppel M,Holper E,Baurecht D,Valenta C

更新日期：2015-01-01 00:00:00

abstract：:The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal o...

journal_title：Skin pharmacology and physiology

authors： Behm B,Kemper M,Babilas P,Abels C,Schreml S

更新日期：2015-01-01 00:00:00

abstract：:It is preferred that topically administered drugs act either dermally or transdermally. For that reason they have to penetrate into the deeper skin layers or permeate the skin. The outermost layer of the human skin, the stratum corneum, is responsible for its barrier function. Most topically administered drugs do not ...

journal_title：Skin pharmacology and physiology

authors： Trommer H,Neubert RH

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Acrolein is a degradation product of lipid peroxide as well as a well-known environmental pollutant. As a hallmark of oxidatively damaged protein, protein carbonyl, including acrolein-protein adduct, has been observed in the skin. However, the influence of protein carbonylation on the stratum corneum (SC) ha...

journal_title：Skin pharmacology and physiology

authors： Iwai I,Hirao T

更新日期：2008-01-01 00:00:00

abstract：:An investigation was undertaken to determine the possible mechanisms of action of medicinal plants used for dermatological pathologies. A total of 14 plant species were selected from the readily available ethnobotanical literature. 5-Lipoxygenase and DPPH (2,2-diphenyl-1-picrylhydrazyl) assays were used to determine t...

journal_title：Skin pharmacology and physiology

authors： Frum Y,Viljoen AM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Research has revealed new insights into the pathogenesis of psoriasis, leading to new therapeutic options. So far the order of changes in the pathogenesis of psoriasis is unclear. The responses to cutaneous leukotriene B4 (LTB4) application have been studied in the past as an in vivo model for inflammation. ...

journal_title：Skin pharmacology and physiology

authors： Hendriks AG,Keijsers RR,Seyger MM,van de Kerkhof PC,van Erp PE

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF THE STUDY:To investigate the role of paraoxonase 1 (PON1) and vitamin E in the pathogenesis of some autoimmune diseases, and to correlate their levels with the disease activity. PROCEDURES:This randomized case control study was performed on 60 subjects: 45 patients [suffering from psoriasis, vitiligo and al...

journal_title：Skin pharmacology and physiology

authors： Ramadan R,Tawdy A,Abdel Hay R,Rashed L,Tawfik D

更新日期：2013-01-01 00:00:00

abstract：:Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most c...

journal_title：Skin pharmacology and physiology

authors： Fernandes AR,Santos AC,Sanchez-Lopez E,Kovačević AB,Espina M,Calpena AC,Veiga FJ,Garcia ML,Souto EB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:About 50% of the sun's radiation arriving on earth is visible light (VIS). For a long time, its effects on human health have not been fully investigated. But recently, the influence of VIS has gained more attention, especially regarding skin physiology. Studies showed various effects, many of them harmful, c...

journal_title：Skin pharmacology and physiology

authors： Wabnik M,Kockott D,Garbe B,Theek C,Heinrich U,Tronnier H,Braun N

更新日期：2019-01-01 00:00:00

abstract：:A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antiox...

journal_title：Skin pharmacology and physiology

authors： Brieva A,Philips N,Tejedor R,Guerrero A,Pivel JP,Alonso-Lebrero JL,Gonzalez S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound heal...

journal_title：Skin pharmacology and physiology

authors： Park G,Oh DS,Kim YU,Park MK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The vitamin D endocrine system, besides multiple other functions, regulates aging in many tissues, including the skin. It protects the skin against the hazardous effects of many skin age-inducing agents, including ultraviolet radiation. Thus, in the present study we aimed to investigate the relationship betw...

journal_title：Skin pharmacology and physiology

authors： Dawoud NM,Bakry OA,Shoeib MA,Ismael HN

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. METHODS:Thirty women (age 20-52 years) were r...

journal_title：Skin pharmacology and physiology

authors： Srivilai J,Nontakhot K,Nutuan T,Waranuch N,Khorana N,Wisuthiprot W,Scholfield CN,Champachaisri K,Ingkaninan K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which ...

journal_title：Skin pharmacology and physiology

authors： Man MQ,Xin SJ,Song SP,Cho SY,Zhang XJ,Tu CX,Feingold KR,Elias PM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect the skin from these insults. OBJECTIVE:The aim of this study was to determine the ex vivo ascorbic acid penetration and its degradation in the skin after its topical ap...

journal_title：Skin pharmacology and physiology

authors： Leveque N,Muret P,Makki S,Mac-Mary S,Kantelip JP,Humbert P

更新日期：2004-11-01 00:00:00

abstract：:Cutaneous irritation presents a major health problem with serious social and occupational impact. The interaction between an irritant and the human skin depends on multiple factors: the intrinsic properties and the nature of the irritant itself, and specific individual- and environment-related variables. The main path...

journal_title：Skin pharmacology and physiology

authors： Fluhr JW,Darlenski R,Angelova-Fischer I,Tsankov N,Basketter D

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES/AIMS:The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied. For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes >1 microm and 3 nano-emulsions with droplet sizes <100 nm) were tested....

journal_title：Skin pharmacology and physiology

authors： Izquierdo P,Wiechers JW,Escribano E,García-Celma MJ,Tadros TF,Esquena J,Dederen JC,Solans C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. METHODS:Fifty-seven healthy full-term neonates aged < or = 48 h were randomly as...

journal_title：Skin pharmacology and physiology

authors： Garcia Bartels N,Mleczko A,Schink T,Proquitté H,Wauer RR,Blume-Peytavi U

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches are needed to reduce the burden of AD and corticosteroid usage in infants. METHODS:The once-daily consumption of heat-treated probiotic Lactobacillus...

journal_title：Skin pharmacology and physiology

authors： Yan DC,Hung CH,Sy LB,Lue KH,Shih IH,Yang CY,Chen LC,Sun HL,Lee MS,Chambard J,Tanguy J,Hughes-Formella B,Nutten S,Blanchard C

更新日期：2019-01-01 00:00:00

abstract：:The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To 'tell time', most living organisms use internal timing mechanisms known as 'biological clocks'. These 'clocks' coordinate our physiological and behavioral functions and inte...

journal_title：Skin pharmacology and physiology

authors： Mehling A,Fluhr JW

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To use high-speed differential scanning calorimetry (DSC) in the identification of transitions in human stratum corneum (SC). Several scanning rates (100 degrees C/min to 400 degrees C/min) are used. RESULTS:Eight transitions from 0 to 120 degrees C are detected in a significant number of samples. Most of thes...

journal_title：Skin pharmacology and physiology

authors： Silva CL,Nunes SC,Eusébio ME,Pais AA,Sousa JJ

更新日期：2006-01-01 00:00:00

abstract：AIM:The purpose of this study was to characterise C₆₀-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. METHODS:Dispersions were characterised according to their pH, particle size, zeta p...

journal_title：Skin pharmacology and physiology

authors： Souto GD,Pohlmann AR,Guterres SS

更新日期：2015-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi), a relatively new group of epigenetic agents, are being investigated as powerful chemotherapeutics because of their antiproliferative and prodifferentiation effects both in vitro and in vivo, in various tumor cell lines. Only little is known with respect to their effects on norma...

journal_title：Skin pharmacology and physiology

authors： Lemper M,Snykers S,Vanhaecke T,De Paepe K,Rogiers V

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to elucidate the effect of sample preparation and microscope configuration on the results of confocal Raman microspectroscopic evaluation of the penetration of a pharmaceutical active into the skin (depth profiling). METHODS:Pig ear skin and a hydrophilic formulation containing...

journal_title：Skin pharmacology and physiology

authors： Lunter DJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...

journal_title：Skin pharmacology and physiology

authors： Jacques-Jamin C,Duplan H,Rothe H,Vaillant O,Eilstein J,Grégoire S,Cubberley R,Lange D,Ellison C,Klaric M,Hewitt N,Schepky A

更新日期：2017-01-01 00:00:00

abstract：:In the present study, we evaluated the protective action of cream preparations containing seven different types of marigold and rosemary extracts in vivo in healthy volunteers with experimentally induced irritant contact dermatitis (ICD). Marigold and rosemary extracts in base cream DAC (Deutscher Arzneimittel-Codex =...

journal_title：Skin pharmacology and physiology

authors： Fuchs SM,Schliemann-Willers S,Fischer TW,Elsner P

更新日期：2005-07-01 00:00:00

abstract：:Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others i...

journal_title：Skin pharmacology and physiology

authors： Perumal O,Murthy SN,Kalia YN

更新日期：2013-01-01 00:00:00

abstract：:Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and t...

journal_title：Skin pharmacology and physiology

authors： Kobayashi M,Kabashima K,Nakamura M,Tokura Y

更新日期：2009-01-01 00:00:00

abstract：:Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...

journal_title：Skin pharmacology and physiology

authors： Richters R,Falcone D,Uzunbajakava N,Verkruysse W,van Erp P,van de Kerkhof P

更新日期：2015-01-01 00:00:00