Ultraviolet A irradiation increases the permeation of fullerenes into human and porcine skin from C₆₀-poly(vinylpyrrolidone) aggregate dispersions.

Abstract:

AIM:The purpose of this study was to characterise C₆₀-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. METHODS:Dispersions were characterised according to their pH, particle size, zeta potential, and morphology. Skin absorption studies were performed using porcine or human skin under UVA or sham irradiation. RESULTS:The C₆₀ aggregate size was 129 ± 54 nm (as determined by nanoparticle tracking analysis) and the zeta potential was -4.93 ± 1.72 mV. The C₆₀ aggregates presented an irregular shape (as measured by transmission electron microscopy) and permeated through human and porcine skin. CONCLUSIONS:C₆₀-PVP aggregates were adequately characterised. Human skin was less permeable than porcine skin, and the presence of UVA-R increased the C₆₀ content up to the dermis.

journal_name

Skin Pharmacol Physiol

authors

Souto GD,Pohlmann AR,Guterres SS

doi

10.1159/000362175

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

22-30

issue

1

eissn

1660-5527

issn

1660-5535

pii

000362175

journal_volume

28

pub_type

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