Abstract:
BACKGROUND/AIMS:Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. So far, these processes have been detected in vertical histological sections of invasive biopsies and recently in noninvasive horizontal scans. METHODS:In this pilot study, a modified noninvasive 2-photon microscope was applied to measure the collagen/elastin index of skin in vivo. The obtained images permit an immediate vertical survey and allow a conclusion on the dermal composition at once. The collagen/elastin index was quantified by the second harmonic to autofluorescence aging index of dermis (SAAID) depending on volunteers' age (18-66 years), gender, and body area. RESULTS:The highest SAAID was measured at the volar forearm as compared to the abdominal SAAID, which was significantly lower (p < 0.05). The gluteal region showed the significantly lowest SAAID (p < 0.05). The SAAID in female skin was higher compared to male skin and decreased with increasing age. CONCLUSION:These effects are to be considered in subsequent studies to be able to specifically detect and evaluate influences.
journal_name
Skin Pharmacol Physioljournal_title
Skin pharmacology and physiologyauthors
Czekalla C,Schönborn KH,Döge N,Jung S,Darvin ME,Lademann J,Meinke MCdoi
10.1159/000477854subject
Has Abstractpub_date
2017-01-01 00:00:00pages
260-267issue
5eissn
1660-5527issn
1660-5535pii
000477854journal_volume
30pub_type
杂志文章abstract::Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a co...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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journal_title:Skin pharmacology and physiology
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journal_title:Skin pharmacology and physiology
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doi:10.1159/000363579
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000235552
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. OBJECTIVES:This work presents t...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000507456
更新日期:2020-01-01 00:00:00
abstract::The investigation of drug penetration into the stratum corneum (SC) by tape-stripping requires an accurate measure of the amount of SC on each tape-strip in order to determine the depth inside the SC. This study applies infrared densitometry (IR-D) to in vitro tape-stripping using the novel Squame Scan(R) 850A. The de...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000288165
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000131077
更新日期:2008-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000106076
更新日期:2007-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363148
更新日期:2015-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000365730
更新日期:2015-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000499436
更新日期:2019-01-01 00:00:00
abstract::Histone deacetylase inhibitors (HDACi), a relatively new group of epigenetic agents, are being investigated as powerful chemotherapeutics because of their antiproliferative and prodifferentiation effects both in vitro and in vivo, in various tumor cell lines. Only little is known with respect to their effects on norma...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000351363
更新日期:2014-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000368444
更新日期:2015-01-01 00:00:00
abstract::The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal o...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000439030
更新日期:2015-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2010-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000447016
更新日期:2016-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501731
更新日期:2019-01-01 00:00:00
abstract::Talarozole is a new highly potent and selective azole derivative which inhibits cytochrome-P450-dependent all-trans-retinoic acid catabolism. It is in clinical development for the treatment of psoriasis and acne. However, no local pharmacokinetic data on the diffusion behaviour of talarozole in the skin itself are ava...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000323012
更新日期:2011-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501131
更新日期:2019-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000091978
更新日期:2006-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
abstract::In the present study, we investigated the effects of tomato extract (TE) containing lycopene and palm fruit extract (PE) rich in carotenoids on the growth and pigmentation of melanocyte cultures of Caucasian origin. The extracts were tested at different concentrations and in combination with vitamins E and C. Melanocy...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000080217
更新日期:2004-09-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000093984
更新日期:2006-01-01 00:00:00
abstract::The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000477417
更新日期:2017-01-01 00:00:00
abstract::Along with antibiotics, antihistamines are the most widely used systemic drugs in dermatology. This is attributable to the major role played by histamine in common diseases such as urticaria and atopic eczema. Of the currently recognised four subtypes of G protein-coupled histamine receptors, only the H1 and H2 subtyp...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000086667
更新日期:2005-09-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000475472
更新日期:2017-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000319602
更新日期:2010-01-01 00:00:00
abstract::Biogenic amines are potential irritants e.g. in fish-, meat-, milk- and egg-processing professions like cooks, butchers and bakers. The aim of this study was to test the irritative and barrier-disrupting properties of the biogenic amines ammonium hydroxide (AM), dimethylamine (DMA) and trimethylamine (TMA). A repeated...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-03-01 00:00:00
abstract::The aim of the study was to examine the effectiveness of the oxidized form of nicotinamide adenine dinucleotide (NAD(+)), adenosine precursor, in 37 patients suffering from psoriasis. As NAD(+) is known to be relatively unstable, the second goal was to establish the proper conditions for the satisfactory stability of ...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
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更新日期:2007-01-01 00:00:00