Influence of Buffers of Different pH and Composition on the Murine Skin Barrier, Epidermal Proliferation, Differentiation, and Inflammation.

abstract：:The human skin barrier is an important part of the skin's intactness and its functionality is a precondition for healthy skin. Ingredients in cosmetic formulations, especially penetration enhancers, can influence this barrier function as they transport active agents into deeper skin layers. In this study different cos...

journal_title：Skin pharmacology and physiology

authors： Heinrich K,Heinrich U,Tronnier H

更新日期：2014-01-01 00:00:00

abstract：:Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a co...

journal_title：Skin pharmacology and physiology

authors： Le Vu P,Takatori R,Iwamoto T,Akagi Y,Satsu H,Totsuka M,Chida K,Sato K,Shimizu M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...

journal_title：Skin pharmacology and physiology

authors： Jacques-Jamin C,Duplan H,Rothe H,Vaillant O,Eilstein J,Grégoire S,Cubberley R,Lange D,Ellison C,Klaric M,Hewitt N,Schepky A

更新日期：2017-01-01 00:00:00

abstract：:The investigation of drug penetration into the stratum corneum (SC) by tape-stripping requires an accurate measure of the amount of SC on each tape-strip in order to determine the depth inside the SC. This study applies infrared densitometry (IR-D) to in vitro tape-stripping using the novel Squame Scan(R) 850A. The de...

journal_title：Skin pharmacology and physiology

authors： Hahn T,Hansen S,Neumann D,Kostka KH,Lehr CM,Muys L,Schaefer UF

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics and increased skin surface area exposure. METHODS:The ability of urea, a low molecular-weight h...

journal_title：Skin pharmacology and physiology

authors： Vieille-Petit A,Blickenstaff N,Coman G,Maibach H

更新日期：2015-01-01 00:00:00

abstract：:Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous...

journal_title：Skin pharmacology and physiology

authors： Wohlrab J,Neubert RH,Sommer E,Michael J

更新日期：2016-01-01 00:00:00

abstract：:Along with antibiotics, antihistamines are the most widely used systemic drugs in dermatology. This is attributable to the major role played by histamine in common diseases such as urticaria and atopic eczema. Of the currently recognised four subtypes of G protein-coupled histamine receptors, only the H1 and H2 subtyp...

journal_title：Skin pharmacology and physiology

authors： Greaves MW

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND/AIMS:Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound heal...

journal_title：Skin pharmacology and physiology

authors： Park G,Oh DS,Kim YU,Park MK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The skin has become very attractive as a route for drug administration. Optimization of topical drug formulations by the addition of penetration enhancers may facilitate the passage of drugs through the stratum corneum. METHODS:In this paper, the skin penetration effect of phytosphingosine and 9 derive...

journal_title：Skin pharmacology and physiology

authors： Veryser L,Boonen J,Taevernier L,Guillaume J,Risseeuw M,Shah SN,Roche N,Van Calenbergh S,De Spiegeleer B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Research has revealed new insights into the pathogenesis of psoriasis, leading to new therapeutic options. So far the order of changes in the pathogenesis of psoriasis is unclear. The responses to cutaneous leukotriene B4 (LTB4) application have been studied in the past as an in vivo model for inflammation. ...

journal_title：Skin pharmacology and physiology

authors： Hendriks AG,Keijsers RR,Seyger MM,van de Kerkhof PC,van Erp PE

更新日期：2014-01-01 00:00:00

abstract：:Solid lipid nanoparticles (SLNs) can enhance drug penetration into the skin, yet the mechanism of the improved transport is not known in full. To unravel the influence of the drug-particle interaction on penetration enhancement, 3 glucocorticoids (GCs), prednisolone (PD), the diester prednicarbate (PC) and the monoest...

journal_title：Skin pharmacology and physiology

authors： Schlupp P,Blaschke T,Kramer KD,Höltje HD,Mehnert W,Schäfer-Korting M

更新日期：2011-01-01 00:00:00

abstract：AIM AND METHODS:Drug development in dermatotherapy and also development of transdermal therapeutic systems (TTS) demand high-predictive in vitro models to estimate drug levels in skin and systemic uptake. Here we compare three ready-to-use models, reconstructed human epidermis, split porcine skin and the perfused porci...

journal_title：Skin pharmacology and physiology

authors： Mahmoud A,Haberland A,Dürrfeld M,Heydeck D,Wagner S,Schafer-Korting M

更新日期：2005-01-01 00:00:00

abstract：:Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...

journal_title：Skin pharmacology and physiology

authors： Richters R,Falcone D,Uzunbajakava N,Verkruysse W,van Erp P,van de Kerkhof P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The vitamin D endocrine system, besides multiple other functions, regulates aging in many tissues, including the skin. It protects the skin against the hazardous effects of many skin age-inducing agents, including ultraviolet radiation. Thus, in the present study we aimed to investigate the relationship betw...

journal_title：Skin pharmacology and physiology

authors： Dawoud NM,Bakry OA,Shoeib MA,Ismael HN

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. METHODS:C...

journal_title：Skin pharmacology and physiology

authors： Yamate Y,Hiramoto K,Sato EF

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:About 50% of the sun's radiation arriving on earth is visible light (VIS). For a long time, its effects on human health have not been fully investigated. But recently, the influence of VIS has gained more attention, especially regarding skin physiology. Studies showed various effects, many of them harmful, c...

journal_title：Skin pharmacology and physiology

authors： Wabnik M,Kockott D,Garbe B,Theek C,Heinrich U,Tronnier H,Braun N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. OBJECTIVES:This work presents t...

journal_title：Skin pharmacology and physiology

authors： Bow JR,Sonoki Y,Uchiyama M,Shimizu E,Tanaka K,Dauskardt RH

更新日期：2020-01-01 00:00:00

abstract：:Squalene is a major sebum lipid which is easily peroxidized by ultraviolet A (UVA) irradiation, generating products that can stress keratinocytes. Prevention of squalene photooxidation with antioxidants could potentially help defend skin from environmental stress. Previously, we have systematically characterized butyl...

journal_title：Skin pharmacology and physiology

authors： Zhou D,Weng X

更新日期：2019-01-01 00:00:00

abstract：:Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and t...

journal_title：Skin pharmacology and physiology

authors： Kobayashi M,Kabashima K,Nakamura M,Tokura Y

更新日期：2009-01-01 00:00:00

abstract：:In a clinical study, the skin penetration properties of melatonin 0.01% in a cream and 0.01 and 0.03% in a solution were investigated by evaluation of the serum melatonin levels over a 24-hour time course in 15 healthy volunteers. Blood samples for melatonin measurements were taken at 9.00 a.m. before applying the tes...

journal_title：Skin pharmacology and physiology

authors： Fischer TW,Greif C,Fluhr JW,Wigger-Alberti W,Elsner P

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. METHODS:Thirty women (age 20-52 years) were r...

journal_title：Skin pharmacology and physiology

authors： Srivilai J,Nontakhot K,Nutuan T,Waranuch N,Khorana N,Wisuthiprot W,Scholfield CN,Champachaisri K,Ingkaninan K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...

journal_title：Skin pharmacology and physiology

authors： Goto K,Hiramoto K,Kawakita M,Yamaoka M,Ooi K

更新日期：2018-01-01 00:00:00

abstract：:Carotenoids could serve as marker substances of the antioxidant status of the human skin. In the present study, an optical skin scanner was used to analyse the carotenoid concentration obtained from 4 volunteers over a period of 13 days. The measurements were taken daily at different time points. In addition, the volu...

journal_title：Skin pharmacology and physiology

authors： Lademann J,Köcher W,Yu R,Meinke MC,Na Lee B,Jung S,Sterry W,Darvin ME

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Keloids result from aberrations in the normal wound healing cascade and can lead to pruritus, contractures and pain. The underlying mechanisms of excessive scarring are not yet understood, and most therapeutic strategies remain unsatisfactory. Psoriasin (S100A7) and koebnerisin (S100A15) are released by...

journal_title：Skin pharmacology and physiology

authors： Gauglitz GG,Bureik D,Zwicker S,Ruzicka T,Wolf R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cetuximab is a member of a new family of antineoplastic agents that inhibit the epidermal growth factor receptor (EGF-R), and which are increasingly being used in the treatment of solid tumors. METHODS:We have observed new secondary side effects. We present here 2 patients with acneiform eruption secondary ...

journal_title：Skin pharmacology and physiology

authors： Gencoglan G,Ceylan C

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Retinoic acid (RA) and benzoyl peroxide (BP) were studied, comparing their keratolytic efficacy and water barrier disruption to that of salicylic acid (SA), a well-established keratolytic, under similar conditions. PATIENTS/METHODS:Six volunteers were included in this blinded study. Eleven randomized test s...

journal_title：Skin pharmacology and physiology

authors： Waller JM,Dreher F,Behnam S,Ford C,Lee C,Tiet T,Weinstein GD,Maibach HI

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:The skin, as the outermost organ, protects against exogenous hazards (outside-in barrier) and prevents the loss of essential parts of the body (inside-out barrier). The epidermal barrier exerts several functions with specific morphological elements. Regional differences in skin functions are well known. ...

journal_title：Skin pharmacology and physiology

authors： Kleesz P,Darlenski R,Fluhr JW

更新日期：2012-01-01 00:00:00

abstract：:The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...

journal_title：Skin pharmacology and physiology

authors： Garcia-Peterson LM,Wilking-Busch MJ,Ndiaye MA,Philippe CGA,Setaluri V,Ahmad N

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches are needed to reduce the burden of AD and corticosteroid usage in infants. METHODS:The once-daily consumption of heat-treated probiotic Lactobacillus...

journal_title：Skin pharmacology and physiology

authors： Yan DC,Hung CH,Sy LB,Lue KH,Shih IH,Yang CY,Chen LC,Sun HL,Lee MS,Chambard J,Tanguy J,Hughes-Formella B,Nutten S,Blanchard C

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES/AIMS:The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied. For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes >1 microm and 3 nano-emulsions with droplet sizes <100 nm) were tested....

journal_title：Skin pharmacology and physiology

authors： Izquierdo P,Wiechers JW,Escribano E,García-Celma MJ,Tadros TF,Esquena J,Dederen JC,Solans C

更新日期：2007-01-01 00:00:00