解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Methyl-CpG binding domain proteins (MBD) can specifically bind to methylated CpG sites and play important roles in epigenetic gene regulation. Here, we identified and functionally characterized the MBD protein in Tribolium castaneum. T. castaneum genome encodes only one MBD protein: TcMBD2/3. RNA interference targetin...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.12.018
更新日期:2020-05-01 00:00:00
abstract::Despite the broad variety of available microRNA (miRNA) prediction tools, their application to the discovery and annotation of novel miRNA genes in domestic species is still limited. In this study we designed a comprehensive pipeline (eMIRNA) for miRNA identification in the yet poorly annotated porcine genome and demo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.12.005
更新日期:2020-05-01 00:00:00
abstract::CircRNA is a specific type of non-coding RNA that has been shown to have an important role in mammary gland (MG) activity, but no study of MG circRNA activity in sheep so far. In this study, the expression profile of circRNAs was investigated using RNA-Seq in MG parenchyma at peak lactation from Small-Tailed Han sheep...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.12.014
更新日期:2020-05-01 00:00:00
abstract::The present investigation was focused to study genomic diversity of Indian swamp buffalo populations through reduced representation approach (ddRAD). The heterozygosity (FST) among the swamp buffaloes was 0.11 between Assam and Manipuri; 0.20 between swamp (Manipuri) and riverine buffaloes; 0.30 between swamp (Manipur...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.01.010
更新日期:2020-05-01 00:00:00
abstract::Non-coding RNA (ncRNA) is a kind of RNA, produced by genomic transcription and does not encode protein, but can regulate the function of genes, thus widely regulating pathological and physiological processes. The dynamic balance of the reticular structure between them is needed to regulate the homeostasis, the abnorma...
journal_title:Genomics
pub_type: 杂志文章,评审
doi:10.1016/j.ygeno.2019.10.006
更新日期:2020-03-01 00:00:00
abstract::In this investigation, whole-genome identification and functional characterization of the cotton dehydrin genes was carried out. A total of 16, 7, and 7 dehydrin proteins were identified in G. hirsutum, G. arboreum and G. raimondii, respectively. Through RNA sequence data and RT-qPCR validation, Gh_A05G1554 (GhDHN_03)...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.11.003
更新日期:2020-03-01 00:00:00
abstract::We analyzed the whole genomes of cecum microbiomes of Ethiopian indigenous chickens from two distinct geographical zones: Afar (AF) district (Dulecha, 730 m above sea level) and Amhara (AM) district (Menz Gera Midir, 3300 m). Through metagenomic analysis we found that microbial populations were mainly dominated by Bac...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.11.011
更新日期:2020-03-01 00:00:00
abstract::Circular RNAs (circRNAs) are a new kind of endogenous non-coding RNAs, which have been discovered continuously. More and more studies have shown that circRNAs are related to the occurrence and development of human diseases. Identification of circRNAs associated with diseases can contribute to understand the pathogenes...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.08.001
更新日期:2020-03-01 00:00:00
abstract::Madin-Darby canine kidney(MDCK) cells can be used to prepare cell-based influenza vaccines; however, little is known regarding the effect of lncRNA regulatorson tumorigenicity. In the present study, two cell lines with low tumorigenicity were screened from highly tumorigenic MDCK cell lines using monoclonal cell techn...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.08.002
更新日期:2020-03-01 00:00:00
abstract::Differentiation of Wharton's Jelly-Mesenchymal Stem cells (WJ-MSCs) into cardiomyocytes (CMs) in vitro has been reported widely although contradictions remain regarding the maturation of differentiated MSCs into fully functioning CMs. Studies suggest that use of epigenetic modifiers like 5'Azacytidine (5-AC) in MSCs d...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.08.007
更新日期:2020-03-01 00:00:00
abstract::The promoter is a regulatory DNA region and important for gene transcriptional regulation. It is located near the transcription start site (TSS) upstream of the corresponding gene. In the post-genomics era, the availability of data makes it possible to build computational models for robustly detecting the promoters as...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.08.009
更新日期:2020-03-01 00:00:00
abstract::In response to nutrient deprivation, the ubiquitous Gram-negative soil bacterium Myxococcus xanthus undergoes a well-characterized developmental response, resulting in the formation of a multicellular fruiting body. The center of the fruiting body consists of myxospores; surrounding this structure are rod-shaped perip...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.09.008
更新日期:2020-03-01 00:00:00
abstract::Temporal lobe epilepsy (TLE) is the most prevalent and often devastating form of epilepsy. The molecular mechanism underlying the development of TLE remains largely unclear, which hinders the discovery of effective antiepileptogenic drugs. Here we adopted a systems-level approach integrating transcriptomic profiles of...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.09.020
更新日期:2020-03-01 00:00:00
abstract::Sogatella furcifera is an important rice pest. In order to understand the molecular basis of the sex determination in this pest, we performed de novo transcriptome sequencing of six cDNA libraries (three biological replicates) of female and male fifth-instar nymphs. Total 65,199 unigenes were obtained, with an average...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.06.024
更新日期:2020-03-01 00:00:00
abstract::Flowering is a prerequisite for pear fruit production. Therefore, the development of flower buds and the control of flowering time are important for pear trees. However, the molecular mechanism of pear flowering is unclear. SOC1, a member of MADS-box family, is known as a flowering signal integrator in Arabidopsis. We...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.09.011
更新日期:2020-03-01 00:00:00
abstract::We sequenced the mitogenomes of Astictopterus jama, Isoteinon lamprospilus and Notocrypta curvifascia to obtain further insight into the mitogenomic architecture evolution and performed phylogenetic reconstruction using 29 Hesperiidae mitogenome sequences. The complete mitogenome sequences of A. jama, I. lamprospilus ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.03.006
更新日期:2020-01-01 00:00:00
abstract::The avian embryo develops within a specialized biological container (eggshell) that contains crucial nutritional compartments (albumen, yolk). We analyzed the transcriptome of ovary and three segments of oviduct, including magnum, isthmus and uterus in the chicken during egg formation. RNA-Seq libraries (42 in total) ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.02.003
更新日期:2020-01-01 00:00:00
abstract::Abnormal histone modifications (HMs) and transcription factors (TFs) can alter the expression of cancer-related genes to promote tumorigenesis. We studied the variations of 11 HMs and 2 TFs in human breast cancer cells (MCF-7) compared to human normal mammary epithelial cells (HMEC), and the effects of HMs/TFs in vari...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.05.026
更新日期:2020-01-01 00:00:00
abstract::Most teleosts undergo a thyroid hormone (TH) regulated larval to juvenile transition known as metamorphosis. In Pleuronectiformes (flatfish), metamorphosis is most dramatic, and one eye of the symmetric pelagic larvae migrates to the opposite side of the head, giving rise to an asymmetric benthic juvenile with both ey...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.04.011
更新日期:2020-01-01 00:00:00
abstract::Balanced reciprocal translocation carriers are usually phenotypically normal but are at an increased risk of infertility, recurrent miscarriage or having affected children. Preimplantation genetic testing on chromosomal structural rearrangement (PGT-SR) offers a way to screen against unbalanced embryos. Here, we demon...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.04.001
更新日期:2020-01-01 00:00:00
abstract::Next generation sequencing techniques produce enormous data but its analysis and visualization remains a big challenge. To address this, we have developed Genome Annotator Light(GAL), a Docker based package for genome analysis and data visualization. GAL integrated several existing tools and in-house programs inside a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.03.012
更新日期:2020-01-01 00:00:00
abstract::Grapsoidea and Ocypodoidea, two of the most abundant and economically important groups in Brachyura, are of great commercial value to fisheries and aquaculture. However, the taxonomy of Ocypodoidea and Grapsoidea has long been highly disputed. Previous studies have investigated this problem through phylogenetic analys...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.12.012
更新日期:2020-01-01 00:00:00
abstract::Guard hair and cashmere undercoat are developed from primary and secondary hair follicle, respectively. Little is known about the gene expression differences between primary and secondary hair follicle cycling. In this study, we obtained RNA-seq data from cashmere and milk goats grown at four different seasons. We stu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.02.013
更新日期:2020-01-01 00:00:00
abstract::Brachyuran crabs comprise the most species-rich clade among the crustacean order Decapoda and are divided into several major superfamilies. However, the monophyly of the superfamilies Ocypodoidea and Grapsoidea in their current compositions within the Brachyura remains inconclusive. In this study, the complete mitocho...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.06.004
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis. METHODS:In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagno...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.04.020
更新日期:2020-01-01 00:00:00
abstract::The secretome refers to all the Excreted/Secreted (ES) proteins of a cell, and these are involved in critical biological processes, such as cell-cell communication, and host immune responses. Recently, we introduced the Abundance of Antigenic Aegions (AAR) value to assess the protein antigenic density and to evaluate ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.10.007
更新日期:2019-12-01 00:00:00
abstract::Here, we report the genomic features and the bioremediation potential of Halomonas desertis G11, a new halophilic species which uses crude oil as a carbon and energy source and displays intrinsic resistance to salt stress conditions (optimum growth at 10% NaCl). G11 genome (3.96 Mb) had a mean GC content of 57.82%, 36...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.12.003
更新日期:2019-12-01 00:00:00
abstract::Identifying heterogeneity in chronic obstructive pulmonary disease (COPD) phenotypes is important for the development of personalized medicine. Genome-wide analysis was used to compare the methylation levels of peripheral blood mononuclear cell (PBMC) samples from 24 acute-exacerbation (AE) COPD patients with good/poo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.09.010
更新日期:2019-12-01 00:00:00
abstract::Triple negative breast cancer (TNBC) is more prevalent in African Americans (AAs), has a more aggressive clinical course including a higher mortality rate and an increased occurrence of metastases. This study was designed to determine if racial differences at the molecular level might explain the more aggressive pheno...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.10.010
更新日期:2019-12-01 00:00:00
abstract::Given the vast amount of genomic data, alignment-free sequence comparison methods are required due to their low computational complexity. k-mer based methods can improve comparison accuracy by extracting an effective feature of the genome sequences. The aim of this paper is to extract k-mer intervals of a sequence as ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.11.001
更新日期:2019-12-01 00:00:00
abstract::Sarcoptes scabiei (Acari: Sarcoptidae) causes a common contagious skin disease that affects many mammals. Here, the complete mitochondrial genome of a mite, S. scabiei var. nyctereutis, from Japanese wild raccoon dogs was analyzed. The 13,837bp circular genome contained 13 protein-coding genes, two rRNA genes, and 22 ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.09.002
更新日期:2019-12-01 00:00:00
abstract::Parasites of the genus Plasmodium infect a wide array of hosts, causing malaria in all major groups of terrestrial vertebrates including primates, reptiles, and birds. Molecular mechanisms explaining why some Plasmodium species are virulent, while other closely related malaria pathogens are relatively benign in the sa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.12.004
更新日期:2019-12-01 00:00:00
abstract::A population of chromosome segment substitution lines was developed using KDML105 as the recurrent parent and one of DH212 (IR68586-F2-CA-143) or DH103 (IR68586-F2-CA-31) as the donor parent. The donor parents are part of a doubled haploid population from a cross between CT9993, an upland japonica accession, and IR622...
journal_title:Genomics
pub_type: 杂志文章,评审
doi:10.1016/j.ygeno.2019.10.001
更新日期:2019-10-31 00:00:00
abstract::Single nucleotide polymorphism (SNP) interactions can explain the missing heritability of common complex diseases. Many interaction detection methods have been proposed in genome-wide association studies, and they can be divided into two types: population-based and family-based. Compared with population-based methods,...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.07.014
更新日期:2019-09-01 00:00:00
abstract::Chemotherapeutic response of cancer cells to a given compound is one of the most fundamental information one requires to design anti-cancer drugs. Recently, considerable amount of drug-induced gene expression data has become publicly available, in addition to cytotoxicity databases. These large sets of data provided a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.07.002
更新日期:2019-09-01 00:00:00
abstract::In the present study, we have constructed an interaction network of 29 antibiotic resistant genes along with 777 interactions in E. coli O157:H7. Gene ontology analysis reveals that 94, 89 and 67 genes have roles in the cellular process, biological process and molecular function respectively. Gene complexes related to...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.06.002
更新日期:2019-07-01 00:00:00
abstract::Knowledge of protein subcellular localization is vitally important for both basic research and drug development. With the avalanche of protein sequences emerging in the post-genomic age, it is highly desired to develop computational tools for timely and effectively identifying their subcellular localization purely bas...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.05.017
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Renal fibrosis is a final common pathway of chronic kidney disease. SIRT1, a NAD+-dependent protein deacetylase, deacetylates the p65 of NF-κB and shows protective effects in kidney disorders. miR-373 directly targets the 3'UTR of SIRT1. However, roles of miR-373 in renal fibrosis are unclear. METHODS:TGF-β...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.04.017
更新日期:2019-07-01 00:00:00
abstract::MicroRNAs are small non-coding regulatory RNA molecules that play an important role in the modulation of gene expression during various environmental stresses. Pseudomonas putida RA, a plant growth promoting rhizobacteria (PGPR) colonizes the root surface of plants improving their growth and development during abiotic...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.01.007
更新日期:2019-07-01 00:00:00
abstract::Developmental dysplasia of the hip (DDH) is a common congenital malformation characterized by mismatch in shape between the femoral head and acetabulum, and leads to hip dysplasia. To date, the pathogenesis of DDH is poorly understood and may involve multiple factors, including genetic predisposition. However, compreh...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.02.006
更新日期:2019-05-01 00:00:00