Abstract:
INTRODUCTION:Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis. METHODS:In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power. RESULTS:PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls (Expression ratios of 0.4, 0.68, 0.54 and 0.11; P values of 0.04, 0.02, 0.02 and <0.001 respectively). CONCLUSION:Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%. The current study shows dysregulation of lncRNAs in bladder cancer and implies their role as diagnostic markers in this malignancy.
journal_name
Genomicsjournal_title
Genomicsauthors
Abdolmaleki F,Ghafoui-Fard S,Taheri M,Mordadi A,Afsharpad M,Varmazyar S,Nazparvar B,Oskooei VK,Omrani MDdoi
10.1016/j.ygeno.2019.04.020subject
Has Abstractpub_date
2020-01-01 00:00:00pages
677-682issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(19)30012-6journal_volume
112pub_type
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