Abstract:
:Most teleosts undergo a thyroid hormone (TH) regulated larval to juvenile transition known as metamorphosis. In Pleuronectiformes (flatfish), metamorphosis is most dramatic, and one eye of the symmetric pelagic larvae migrates to the opposite side of the head, giving rise to an asymmetric benthic juvenile with both eyes on the same side of the body. Asymmetric development occurs mostly in the head. To understand the genetic mechanisms underlying this developmental change we have generated a Solea senegalensis metamorphosing flatfish head transcriptome. Our results reveal that THs acting as integrative factors direct a stepwise genetic program that initiates a specific organismal level response followed by cell specific responses that lead to the long-term changes that characterise the post-metamorphic identity and physiology of the head. Flatfish head asymmetric development during metamorphosis and its TH dependency is conserved thus we consider the findings in sole most likely representative of all flatfish species.
journal_name
Genomicsjournal_title
Genomicsauthors
Louro B,Marques JP,Manchado M,Power DM,Campinho MAdoi
10.1016/j.ygeno.2019.04.011subject
Has Abstractpub_date
2020-01-01 00:00:00pages
592-602issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(18)30458-0journal_volume
112pub_type
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