Abstract:
:Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in neurons. In vitro, Cdk5 purified from the nervous tissue phosphorylates both high-molecular-weight neurofilament and microtubule-associated tau. The mouse gene encoding Cdk5 (Cdk5) was found to be 5 kb in length and divided into 12 exons. All of the exon-intron junctions matched the expected consensus sequence with the exception of the splice junction for intron 9, which has AT and AC dinucleotides instead of the usual GT and AG bordering sequence. In the 5'-flanking region of mouse Cdk5, several putative promoter elements were present, including AP1, Sp1, PuF, and TATA motifs. A metal regulatory element was also identified at position -207 to -201. Nucleotide sequence analysis of mouse Cdk5 showed high identity to the homologues of other vertebrate species, indicating that this kinase is highly conserved during evolution. Mouse Cdk5 was mapped to the centromeric region of mouse chromosome 5.
journal_name
Genomicsjournal_title
Genomicsauthors
Ohshima T,Nagle JW,Pant HC,Joshi JB,Kozak CA,Brady RO,Kulkarni ABdoi
10.1006/geno.1995.1194subject
Has Abstractpub_date
1995-08-10 00:00:00pages
585-8issue
3eissn
0888-7543issn
1089-8646pii
S0888-7543(85)71194-9journal_volume
28pub_type
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