Abstract:
:Cytogenetic studies of banded chromosomes and fluorescence in situ hybridization (FISH) of several yeast artificial chromosomes (YACs) that are part of a 128-kb resolution physical map of a portion of 12q13 revealed that 4/14 (28%) lipomas have breakpoints in 12q13. These breakpoints are more than 10 Mb away from the HMGIC gene at 12q14-q15, which is known to be modified in some lipomas. FISH with individual YACs at 12q13 enabled us to identify four YACs that span three breakpoints. Our results suggest that genes other than HMGIC on human chromosome 12 may be involved in the etiology of lipoma development.
journal_name
Genomicsjournal_title
Genomicsauthors
Merscher S,Marondel I,Pedeutour F,Gaudray P,Kucherlapati R,Turc-Carel Cdoi
10.1006/geno.1997.4993subject
Has Abstractpub_date
1997-11-15 00:00:00pages
70-7issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(97)94993-4journal_volume
46pub_type
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