Correlation of serpin-protease expression by comparative analysis of real-time PCR profiling data.

Abstract:

:Imbalanced protease activity has long been recognized in the progression of disease states such as cancer and inflammation. Serpins, the largest family of endogenous protease inhibitors, target a wide variety of serine and cysteine proteases and play a role in a number of physiological and pathological states. The expression profiles of 20 serpins and 105 serine and cysteine proteases were determined across a panel of normal and diseased human tissues. In general, expression of serpins was highly restricted in both normal and diseased tissues, suggesting defined physiological roles for these protease inhibitors. A high correlation in expression for a particular serpin-protease pair in healthy tissues was often predictive of a biological interaction. The most striking finding was the dramatic change observed in the regulation of expression between proteases and their cognate inhibitors in diseased tissues. The loss of regulated serpin-protease matched expression may underlie the imbalanced protease activity observed in pathological states.

journal_name

Genomics

journal_title

Genomics

authors

Badola S,Spurling H,Robison K,Fedyk ER,Silverman GA,Strayle J,Kapeller R,Tsu CA

doi

10.1016/j.ygeno.2006.03.017

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

173-84

issue

2

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(06)00100-5

journal_volume

88

pub_type

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