解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Most parasitic flatworms go through different life stages with important physiological and morphological changes. In this work, we used a transcriptomic approach to analyze the main life-stages of the model tapeworm Hymenolepis microstoma (eggs, cysticercoids, and adults). Our results showed massive transcriptomic cha...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2021.01.005
更新日期:2021-01-21 00:00:00
abstract::The APETALA2/ethylene-responsive factor (AP2/ERF) has important roles in regulating developmental processes and hormone signaling transduction in plants. Pineapple demonstrates a special sensitivity to ethylene, and AP2/ERFs may contribute to this distinct sensitivity of pineapples to ethylene. However, little informa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.040
更新日期:2021-01-20 00:00:00
abstract::Sperm motility is one of the most important indicators to evaluate poultry fertility. In order to explore key molecular regulation roles related to sperm motility, we employed testicular RNA sequencing of pigeon. A total of 705 known and 385 novel microRNAs were identified. Compared with the low sperm motility group, ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.12.024
更新日期:2021-01-01 00:00:00
abstract::To better understand the molecular basis of corpus luteum (CL) development and function RNA-Seq was utilized to identify differentially expressed genes (DEGs) in porcine CL during different physiological stages of the estrous cycle viz. early (EL), mid (ML), late (LL) and regressed (R) luteal. Stage wise comparisons o...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.12.008
更新日期:2021-01-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor of the upper aerodigestive tract. The loss and gain of miRNA function promote cancer development through various mechanisms. RNA sequencing (RNA-seq) and miRNAs sequencing data from the Cancer Genome Atlas (TCGA) was used to show the dysfunctional miRN...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.12.002
更新日期:2021-01-01 00:00:00
abstract::The aim of this study was to elucidate the roles played by circular RNAs (circRNAs) in the mechanism underlying submandibular gland (SMG) dysfunction in hypertension. We employed RNA-seq to analyze the circRNA and mRNA expression profiles of SMGs. Seventy-five differentially expressed (DE) circRNAs and 691 DE mRNAs we...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.11.016
更新日期:2021-01-01 00:00:00
abstract::Transcriptional re-programming in host and pathogen upon leaf and neck infection is an evolving area of research for the rice blast community. Analysis of in planta rice transcriptome in leaf and neck tissues revealed tissue-specific and infection-specific expression of rice and Magnaporthe oryzae genes in host and pa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.12.018
更新日期:2021-01-01 00:00:00
abstract::Amaranth has been proposed as an exceptional alternative for food security and climate change mitigation. Information about the distribution, abundance, or specificity of miRNAs in amaranth species is scare. Here, small RNAs from seedlings under control, drought, heat, and cold stress conditions of the Amaranthus hypo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.11.027
更新日期:2021-01-01 00:00:00
abstract::Bacillus spp. play important roles in production of bioactive natural products with potential agricultural and medical applications. The three families of lipopeptides produced by Bacillus spp. have been most recognized for their antagonistic activity against other microbes, i.e. fengycin, iturin, and surfactin. A nov...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.12.011
更新日期:2021-01-01 00:00:00
abstract::We report monozygotic twin girls with syndromic intellectual disability who underwent exome sequencing but with negative pathogenic variants. To search for variants that are unrecognized by exome sequencing, high-fidelity long-read genome sequencing (HiFi LR-GS) was applied. A 12-kb copy-neutral inversion was precisel...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.038
更新日期:2020-11-04 00:00:00
abstract::Background Bioinformatics tools are of great significance and are used in different spheres of life sciences. There are wide variety of tools available to perform primary analysis of DNA and protein but most of them are available on different platforms and many remain undetected. Accessing these tools separately to pe...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.08.010
更新日期:2020-11-01 00:00:00
abstract::This study presented 96 cox1 and 76 cox3 genes of Amphioctopus neglectus populations. Three distinct lineages were formed from phylogenetic trees and networks constructed using haplotypes. Mitogenomes of A. neglectus-a and A. neglectus-b as the representatives of two lineages separated from population genetics were se...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.06.036
更新日期:2020-11-01 00:00:00
abstract::There is a compelling need to identify novel genetic variants for papillary thyroid cancer (PTC) susceptibility. The Cancer Genome Atlas (TCGA) data showed associations between SPP1 and SPARC mRNA overexpression and aggressive behaviors of PTC, which prompted us to assess potential associations between genetic variant...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.09.018
更新日期:2020-11-01 00:00:00
abstract::Cell wall lytic enzymes play key roles in biochemical, morphological, genetic research and industry fields. To save time and labor costs, bioinformatic methods are usually adopted to narrow the scope of in vitro experimentation. In this paper, we established a novel machine learning (support vector machine) based iden...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.08.015
更新日期:2020-11-01 00:00:00
abstract::Variation at MHC Class II-DQA locus in riverine and swamp buffaloes (Bubu) has been explored in this study. Through sequencing of buffalo DQA, 48 nucleotide variants identified from 17 individuals, reporting 42 novel alleles, including one pseudogene. Individual animal displayed two to seven variants, suggesting the p...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.07.041
更新日期:2020-11-01 00:00:00
abstract::Identifying physiological and transcriptomic changes can provide insights into the effects of drier air humidity stress on plants. In this study, we selected 6-month-old seedlings of Pterocarya stenoptera as study materials and used physiological index detection and transcriptome sequencing to investigate the adaptati...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.09.027
更新日期:2020-11-01 00:00:00
abstract::In the past decades, the rapid growth of computer and database technologies has led to the rapid growth of large-scale medical datasets. On the other, medical applications with high dimensional datasets that require high speed and accuracy are rapidly increasing. One of the dimensionality reduction approaches is featu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.07.027
更新日期:2020-11-01 00:00:00
abstract::The extremely high proliferation rate of tumor cells contributes to pancreatic cancer (PC) progression. Runt-related transcription factor 1(RUNX1), a key factor in hematopoiesis that was correlated with tumor progression. However, the role of RUNX1 in PC proliferation was still unclear. We found that RUNX1 was signifi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.11.010
更新日期:2020-11-01 00:00:00
abstract::We report for the first time the fragmented mitochondrial (mt) genomes of two Pedicinus species: Pedicinus obtusus and Pedicinus badii, and compared them with the lice of humans and chimpanzees. Despite being congeneric, the two monkey lice are distinct from each other in mt karyotype. The variation in mt karyotype be...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.09.005
更新日期:2020-11-01 00:00:00
abstract::Haemophilia is an X-linked genetic disorder in which A and B types are the most common that occur due to absence or lack of protein factors VIII and IX, respectively. Severity of the disease depends on mutation. Available Machine Learning (ML) methods that predict the mutational severity by using traditional encoding ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.09.020
更新日期:2020-11-01 00:00:00
abstract::Salinity is a major limiting factor in crop production. Exogenous spermidine (spd) effectively ameliorates salt injury, though the underlying molecular mechanism is poorly understood. We have used a suppression subtractive hybridization method to construct a cDNA library that has identified up-regulated genes from ric...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.07.011
更新日期:2020-11-01 00:00:00
abstract::DNA methylation is a potential epigenetic mechanism that regulates genome stability, development, and stress mitigation in plants. It is mediated by cytosine-5 DNA methyltransferases (C5-MTases). We identified 52 wheat C5-MTases; and based on domain structure and phylogenetics, these 52 C5-MTases were classified into ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.08.031
更新日期:2020-11-01 00:00:00
abstract::Cardiovascular disease (CVD) is an important cause of disease-related death worldwide. One of its main pathological bases is imbalances in gene expression. Non-coding RNAs are a class of transcripts that do not encode proteins. They include microRNA (miRNA), long noncoding RNA (lncRNA) and circular RNA (circRNA). They...
journal_title:Genomics
pub_type: 杂志文章,评审
doi:10.1016/j.ygeno.2020.10.024
更新日期:2020-10-22 00:00:00
abstract::Treatment for lower-grade gliomas (LGG) has been challenging. Though emerging approaches such as immunotherapy is promising, it is still faced with immune tolerance, an obstacle that may be overcome by targeting autophagy-related (ATG) genes. After identifying three differentially expressed ATG genes (RIPK2, MUL1 and ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.008
更新日期:2020-10-15 00:00:00
abstract::Pigeonpea is the main protein source for more than one billion people, and it shows a strong adaptation to biotic stress and abiotic stress. Gene duplication is a fundamental process in genome evolution. Although the draft sequence of the pigeonpea genome has been available since 2011, further analysis of tandem dupli...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.003
更新日期:2020-10-11 00:00:00
abstract::DNA N6-methyladenine (6 mA) is an epigenetic modification that plays a vital role in a variety of cellular processes in both eukaryotes and prokaryotes. Accurate information of 6 mA sites in the Rosaceae genome may assist in understanding genomic 6 mA distributions and various biological functions such as epigenetic i...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.09.054
更新日期:2020-10-01 00:00:00
abstract::Fruit development and ripening are essential components of human and animal diets. Fruit ripening is also a vital plant trait for plant shelf life at the commercial level. In the present study, two apple cultivars, Hanfu wild (HC) and Hanfu mutant (HM), were employed for RNA-Sequencing (RNA-Seq) to explore the genes i...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.09.040
更新日期:2020-09-20 00:00:00
abstract:AIM:The objective of this study is to examine the alterations in the levels of expression of serum lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283 in spinal cord injured (SCI) patients versus healthy control. METHOD:The expression of the selected RNAs in the sera was determined in 23 patients suffering from acute spinal cord i...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.06.018
更新日期:2020-09-01 00:00:00
abstract::CancerEnD is an integrated resource developed for annotating 8524 unique expressed enhancers, associated genes, somatic mutations and copy number variations of 8063 cancer samples from 18 cancer types of TCGA. Somatic mutation data was taken from the COSMIC repository. To delineate the relationship of change in copy n...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.04.028
更新日期:2020-09-01 00:00:00
abstract::Multiple infections by HPV genotypes are frequently detected in HPV+ cervical lesions but the interaction between each viral genotype during carcinogenesis is poorly understood. Here we carried out a comprehensive study to characterize the multiple HPV expression and integration by RNA-seq analyses of 19 invasive cerv...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.05.009
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Copy number variations (CNV) are regional deviations from the normal autosomal bi-allelic DNA content. While germline CNVs are a major contributor to genomic syndromes and inherited diseases, the majority of cancers accumulate extensive "somatic" CNV (sCNV or CNA) during the process of oncogenetic transforma...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.05.008
更新日期:2020-09-01 00:00:00
abstract::A new Alcanivorax sp. VBW004 was isolated from a shallow hydrothermal vent in Azores Island, Portugal. In this study, we determined VBW004 was resistant to copper. This strain showed maximum tolerance of copper concentrations up to 600 μg/mL. Based on 16S rRNA gene sequencing and phylogeny revealed that this strain wa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.06.015
更新日期:2020-09-01 00:00:00
abstract::Helicobacter pylori is a Gram-negative spiral-shaped bacterium that infects half of the human population worldwide and causes chronic inflammation. In the present study, we used the art of computational biology for therapeutic drug targets identification and a multi-epitope vaccine against multi-strains of H. pylori. ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.06.026
更新日期:2020-09-01 00:00:00
abstract::Klebsiella variicola is an emerging pathogen responsible for causing blood-stream infections, urinary and respiratory tract related diseases in humans. In this report, we describe the genome sequence data and phenotypic characterization of K. variicola strain KV093 isolated from India. Comparative genome sequence anal...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.06.004
更新日期:2020-09-01 00:00:00
abstract::MicroRNAs (miRNAs) have been prevalently studied in plants, animals, and viruses. However, recent studies show evidences of miRNA-like RNAs (milRNAs) in fungi as well. It is known that after successful infection, pathogens hijack the host machinery and use it for their own growth and multiplication. Alternatively, res...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.05.021
更新日期:2020-09-01 00:00:00
abstract::Single Nucleotide Polymorphism (SNP) is one of the important molecular markers widely used in animal breeding program for improvement of any desirable genetic traits. Considering this, the present study was carried out to identify, annotate and analyze the SNPs related to four important traits of buffalo viz. milk vol...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.04.012
更新日期:2020-09-01 00:00:00
abstract::Formyl peptide receptors (FPRs) were firstly detected in immune cells where they act as key mediators of leukocyte chemotaxis, promoting the host defense against pathogens. Recently, three paralogs were reported in Homo sapiens (FPR1-3) and seven paralogs in Mus musculus (FPR1, FPRrs1-4, FPRrs6 and FPRrs7), but inform...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.03.015
更新日期:2020-07-01 00:00:00
abstract::Through an exhaustive homology-based approach, coupled with manual efforts, we annotated and characterized 128 sensory neuron membrane proteins (SNMPs) from genomes and transcriptomes of 22 coleopteran species, with 107 novel candidates. Remarkably, we discovered, for the first time, a novel SNMP group, defined as Gro...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.03.005
更新日期:2020-07-01 00:00:00
abstract::Perilipin 1 (PLIN1) protein, also known as lipid droplet-associated protein, is encoded by the PLIN1 gene and is able to anchor itself to the membranes of lipid droplets. The phosphorylation of PLIN1 is critical for the mobilization of fat in adipose tissue and plays an important role in regulating lipolysis and lipid...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.01.012
更新日期:2020-05-01 00:00:00
abstract::To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related with EOC risk. Specifi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.02.002
更新日期:2020-05-01 00:00:00