Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury.

Abstract:

AIM:The objective of this study is to examine the alterations in the levels of expression of serum lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283 in spinal cord injured (SCI) patients versus healthy control. METHOD:The expression of the selected RNAs in the sera was determined in 23 patients suffering from acute spinal cord injury, 41 individuals with chronic spinal cord injury, and 36 healthy control using real-time reverse-transcription polymerase chain reaction method. RESULTS:The results showed that lncRNA-TSIX and the TP53INP2 mRNA expression levels in SCI patients was overexpressed in comparison to the control group alongside with a significant downregulation of miR-1283. Statistically,there was a highly significant positive correlation between lnc-RNA-TRIX and TP53INP2 mRNA with inverse correlation between miRNA-1283 and lnc-RNA-TRIX based on fold changes. CONCLUSION:Up-regulation of lncRNA-TSIX, TP53INP2 mRNA with downregulation of miRNA-1283 might be closely associated with progression of SCI.

journal_name

Genomics

journal_title

Genomics

authors

Salah SMM,Matboli M,Nasser HE,Abdelnaiem IA,Shafei AE,El-Asmer MF

doi

10.1016/j.ygeno.2020.06.018

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

3315-3321

issue

5

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(20)30537-1

journal_volume

112

pub_type

杂志文章

相关文献

GENOMICS文献大全
  • MiRNA expression signatures induced by Marek's disease virus infection in chickens.

    abstract::MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Emerging evidence suggests that differential miRNA expression is associated with viral infection and cancer. Marek's disease virus infection induces lymphoma in chickens. However, the host defense response ag...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2011.11.004

    authors: Tian F,Luo J,Zhang H,Chang S,Song J

    更新日期:2012-03-01 00:00:00

  • A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus.

    abstract::We describe a high-resolution radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia (AT) disease gene loci. The order and intermarker distances of 32 chromosome 11q22-q23 markers were determined by a multipoint maximum likelihood method of analysis of the cosegregation of markers in 1...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1993.1275

    authors: Richard CW 3rd,Cox DR,Kapp L,Murnane J,Cornelis F,Julier C,Lathrop GM,James MR

    更新日期:1993-07-01 00:00:00

  • Effect of selenocystine on gene expression profiles in human keloid fibroblasts.

    abstract::In this study, selenocystine, a nutritionally available selenoamino acid, was identified for the first time as a novel agent with anti proliferative activity on human keloids. The 20 μM concentration after 48 h treatment used here was the most effective to reduce keloid fibroblast growth. We analyzed the gene expressi...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2011.02.009

    authors: De Felice B,Garbi C,Wilson RR,Santoriello M,Nacca M

    更新日期:2011-05-01 00:00:00

  • Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene.

    abstract::Insulin-like growth factor binding proteins (IGFBPs) constitute a family of at least six secreted proteins that bind insulin-like growth factors I and II (IGF-I and -II) and are capable of modifying IGF actions on target cells. We previously have purified an approximately 29-kDa IGFBP that is secreted by myoblasts dur...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1195

    authors: Kou K,Jenkins NA,Gilbert DJ,Copeland NG,Rotwein P

    更新日期:1994-04-01 00:00:00

  • Single-strand conformational polymorphism (SSCP) mapping of the mouse genome: integration of the SSCP, microsatellite, and gene maps of mouse chromosome 1.

    abstract::Interspersed repetitive sequence (IRS) PCR and repetitive element-to-bubble (IRS-bubble) PCR have been utilized to rapidly generate large numbers of mouse-specific, chromosome 1-enriched STSs from mouse-hamster somatic cell hybrids. Single-strand conformational polymorphism (SSCP) has been used to localize 39 new repe...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/s0888-7543(11)80007-8

    authors: Hunter KW,Watson ML,Rochelle J,Ontiveros S,Munroe D,Seldin MF,Housman DE

    更新日期:1993-12-01 00:00:00

  • Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1).

    abstract::The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published. In this report, we present a corrected genomic sequence, genomic structure, and refined chromosomal location for KiSS-1. The genomic organization of the sequence revea...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5566

    authors: West A,Vojta PJ,Welch DR,Weissman BE

    更新日期:1998-11-15 00:00:00

  • Genotyping with TaqMAMA.

    abstract::TaqMAMA combines the quantitative strengths of TaqMan with the allele-specific PCR of MAMA. In this article we develop TaqMAMA as a technique for screening human DNA samples for known genetic polymorphisms. In the first set of experiments, plasmids that model all types of genetic polymorphisms were used to understand ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2003.08.005

    authors: Li B,Kadura I,Fu DJ,Watson DE

    更新日期:2004-02-01 00:00:00

  • Comparison of normalization methods with microRNA microarray.

    abstract::MicroRNAs (miRNAs) are a group of RNAs that play important roles in regulating gene expression and protein translation. In a previous study, we established an oligonucleotide microarray platform to detect miRNA expression. Because it contained only hundreds of probes, data normalization was difficult. In this study, t...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2008.04.002

    authors: Hua YJ,Tu K,Tang ZY,Li YX,Xiao HS

    更新日期:2008-08-01 00:00:00

  • Genetic variants associated with primary open angle glaucoma in Indian population.

    abstract::Glaucoma is a very common disorder of the eye wherein the disturbance of the structural or functional integrity of the optic nerve causes characteristic atrophic changes in the optic nerve, which may lead to specific visual field defects over time. Primary open angle glaucoma (POAG) is most frequent among the three pr...

    journal_title:Genomics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygeno.2016.11.003

    authors: Kumar S,Malik MA,K S,Sihota R,Kaur J

    更新日期:2017-01-01 00:00:00

  • Cloning the human gene for macrophage migration inhibitory factor (MIF).

    abstract::Macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine. However, recent work strongly suggests a wider role for MIF beyond the immune system. It is expressed specifically in the differentiating cells of the immunologically privileged eye lens and brain, is a delayed early response gene ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1011

    authors: Paralkar V,Wistow G

    更新日期:1994-01-01 00:00:00

  • Haplotypes in cystic fibrosis patients with or without pancreatic insufficiency from four European populations.

    abstract::We examined the allele and haplotype frequencies of five polymorphic DNA markers in 355 European cystic fibrosis (CF) patients (from Belgium, the German Democratic Republic, Greece, and Italy) who were divided into two groups according to whether they were or not taking supplementary pancreatic enzymes. The level of l...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(89)90131-6

    authors: Devoto M,De Benedetti L,Seia M,Piceni Sereni L,Ferrari M,Bonduelle ML,Malfroot A,Lissens W,Balassopoulou A,Adam G

    更新日期:1989-11-01 00:00:00

  • Genomic mapping by anchoring random clones: a mathematical analysis.

    abstract::A complete physical map of the DNA of an organism, consisting of overlapping clones spanning the genome, is an extremely useful tool for genomic analysis. Various methods for the construction of such physical maps are available. One approach is to assemble the physical map by "fingerprinting" a large number of random ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(91)90004-x

    authors: Arratia R,Lander ES,Tavaré S,Waterman MS

    更新日期:1991-12-01 00:00:00

  • Identification of small non-coding RNAs in the planarian Dugesia japonica via deep sequencing.

    abstract::Freshwater planarian flatworm possesses an extraordinary ability to regenerate lost body parts after amputation; it is perfect organism model in regeneration and stem cell biology. Recently, small RNAs have been an increasing concern and studied in many aspects, including regeneration and stem cell biology, among othe...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2012.03.001

    authors: Qin YF,Zhao JM,Bao ZX,Zhu ZY,Mai J,Huang YB,Li JB,Chen G,Lu P,Chen SJ,Su LL,Fang HM,Lu JK,Zhang YZ,Zhang ST

    更新日期:2012-05-01 00:00:00

  • Second-generation approach to the construction of yeast artificial-chromosome libraries.

    abstract::We describe an improved method for construction of yeast artificial-chromosome (YAC) libraries that contain large inserts of foreign DNA. The procedure consists of seven steps: (i) preparation of human DNA in agarose beads; (ii) partial digestion of the DNA with EcoRI; (iii) electrophoretic elimination of the smaller ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(90)90285-3

    authors: Imai T,Olson MV

    更新日期:1990-10-01 00:00:00

  • Linkage map of nine loci defined by polymorphic DNA markers assigned to rat chromosome 13.

    abstract::A genetic map of nine loci defined by polymorphic DNA markers was created using a single cross of F344/N and LEW/N rats. The markers contained polymorphic simple sequence repeats identified in five genes, renin (Ren), cardiac troponin T (Tnnt3), synaptotagmin (Syt2), Na+,K(+)-ATPase catalytic subunit (Atp1a2), and the...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1993.1466

    authors: Remmers EF,Goldmuntz EA,Zha H,Mathern P,Du Y,Crofford LJ,Wilder RL

    更新日期:1993-11-01 00:00:00

  • Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene.

    abstract::Phenol- and monoamine-metabolizing sulfotransferases (STP and STM, respectively) are members of a superfamily of enzymes that add sulfate to a variety of xenobiotics and endobiotics containing hydroxyl or amino functional groups. To characterize related sulfotransferase genes further, we used extra-long PCR (XL-PCR) t...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.4575

    authors: Gaedigk A,Beatty BG,Grant DM

    更新日期:1997-03-01 00:00:00

  • Fractalkine shares signal sequence with TARC: gene structures and expression profiles of two chemokine genes.

    abstract::In the process of cloning the gene (Scyd1) encoding the mouse CX3C chemokine fractalkine, we identified a novel cDNA that encodes a chimeric molecule termed fracTARC. This molecule is a variant form of the mouse CC chemokine, TARC (for thymus- and activation-regulated chemokine), bearing the fractalkine signal sequenc...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.2001.6585

    authors: Hiroyama T,Iwama A,Nakamura Y,Nakauchi H

    更新日期:2001-07-01 00:00:00

  • Mapping of the gene TCF2 coding for the transcription factor LFB3 to human chromosome 17 by polymerase chain reaction.

    abstract::A human clone corresponding to the gene for the DNA-binding factor LFB3, a protein highly homologous to the liver-specific transcription factor LFB1, has been isolated and partially sequenced. This gene is designated TCF2. Oligonucleotide primers have been designed for LFB3 and used to amplify specifically the human g...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(90)90239-q

    authors: Abbott C,Piaggio G,Ammendola R,Solomon E,Povey S,Gounari F,De Simone V,Cortese R

    更新日期:1990-09-01 00:00:00

  • A transcript map of a 10-Mb region of chromosome 19: a source of genes for human disorders, including candidates for genes involved in asthma, heart defects, and eye development.

    abstract::Several projects have produced maps of the physical position of genes within the human genome, either on a genome-wide scale or of a more detailed subsection of a chromosome. However, these maps largely rely on the mapping of expressed sequences (cDNAs and ESTs) back onto physical maps by their localization onto speci...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1999.6075

    authors: Hamshere M,Cross S,Daniels M,Lennon G,Brook JD

    更新日期:2000-02-01 00:00:00

  • Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.

    abstract::We employed the polymerase chain reaction and genomic DNA library screening to clone novel human genes, GPR9 and GPR10, and a rat gene, GPR14. GPR9, GPR10, and GPR14 each encode G protein-coupled receptors. GPR10 and GPR14 are intronless within their coding regions, while GPR9 contains at least one intron. The recepto...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1995.9996

    authors: Marchese A,Heiber M,Nguyen T,Heng HH,Saldivia VR,Cheng R,Murphy PM,Tsui LC,Shi X,Gregor P

    更新日期:1995-09-20 00:00:00

  • Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice.

    abstract::Despite antibiotic therapy and vaccination programs, microbial diseases continue to be the leading cause of morbidity and mortality worldwide. The genetic basis of the host response to infection is complex, and its understanding has been facilitated through the study of mouse models of human infectious diseases. Genet...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1997.5116

    authors: Sebastiani G,Olien L,Gauthier S,Skamene E,Morgan K,Gros P,Malo D

    更新日期:1998-01-15 00:00:00

  • Genomic organization and genetic mapping of the neuroimmune gene I2rf5 to mouse chromosome 4.

    abstract::The nervous and immune systems share many functional and molecular similarities, including shared surface antigens, secretions of soluble factors, and cross-modulatory effects. We have identified previously a novel mRNA termed F5, which is expressed only in activated T lymphocytes and mature, postmitotic neurons. Tiss...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(95)80137-b

    authors: Autieri MV,Kozak CA,Cohen JA,Prystowsky MB

    更新日期:1995-01-01 00:00:00

  • Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3.

    abstract::A gene family of Na+/H+ exchanger isoforms has been identified. Characterization of rabbit NHE3 suggests that it is the apical epithelial Na+/H+ exchanger isoform responsible for transepithelial, electroneutral Na+ absorption in intestinal and renal epithelial cells. We have previously isolated from a human kidney cor...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1993.1122

    authors: Brant SR,Bernstein M,Wasmuth JJ,Taylor EW,McPherson JD,Li X,Walker S,Pouyssegur J,Donowitz M,Tse CM

    更新日期:1993-03-01 00:00:00

  • Prp (proline-rich protein) genes linked to markers Es-12 (esterase-12), Ea-10 (erythrocyte alloantigen), and loci on distal mouse chromosome 6.

    abstract::The closely linked proline-rich protein (Prp) genes, coding for abundant salivary proteins, are located on distal mouse chromosome 6. They are part of a conserved linkage group that is represented on human chromosome 12p. Two other markers, Ea-10 and Es-12, that were previously unassigned to a chromosome are closely l...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(89)90004-9

    authors: Azen EA,Davisson MT,Cherry M,Taylor BA

    更新日期:1989-10-01 00:00:00

  • Confirmation of the assignment of MYCL to chromosome 1 in humans and its position relative to RH, UMPK, and PGM1.

    abstract::Data from family studies demonstrating RH:MYCL linkage (zeta = 4.07 at theta = 0.09) in paternal meioses are presented. Although positive, MYCL:PGM1 lods are not of the magnitude of those for RH:MYCL. Taken together, these results are consistent with the physical assignment of MYCL to 1p32. Furthermore, evidence to su...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(88)90097-3

    authors: Zelinski T,Verville G,White L,Hamerton JL,McAlpine PJ,Lewis M

    更新日期:1988-02-01 00:00:00

  • Genome organization and polymorphism of the murine beta-glucuronidase region.

    abstract::Thirty-eight kilobases of mouse genomic DNA which surround and include the coding sequences for beta-glucuronidase has been mapped. Intron-exon arrangements were determined by hybridization of genomic sequences with cDNA clones, and minimum estimates of gene length (11-17 kb) and intron number were obtained. Only a si...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(88)90105-x

    authors: Moore KJ,Paigen K

    更新日期:1988-01-01 00:00:00

  • Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China.

    abstract::In this study, we systematically screened the polymorphisms of the whole CYP2D6 gene in the populations of four different geographical locations in China, namely, Shanghai, Shantou, Shenyang, and Xi'an, using a sample of 100 subjects from each population. Forty-eight different polymorphisms were detected as well as 12...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2008.05.004

    authors: Qin S,Shen L,Zhang A,Xie J,Shen W,Chen L,Tang J,Xiong Y,Yang L,Shi Y,Feng G,He L,Xing Q

    更新日期:2008-09-01 00:00:00

  • Linkage mapping of human chromosome 10 microsatellite polymorphisms.

    abstract::Ten microsatellite DNA polymorphisms located on human chromosome 10 were regionally mapped using subchromosomal somatic cell hybrids and linkage analysis. The resulting order of the markers from pter-qter was [D10S89, D10S111], D10S107, D10S109, [D10S91, D10S110, D10S108, D10S88, D10S168], and D10S169. Order of the ma...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(92)90455-2

    authors: Decker RA,Moore J,Ponder B,Weber JL

    更新日期:1992-03-01 00:00:00

  • Sequence of the coding region of the bovine fibrillin cDNA and localization to bovine chromosome 10.

    abstract::We report the cDNA sequence for the bovine gene for fibrillin corresponding to the human gene, fibrillin 1 (FBN1), and the localization of the gene to bovine chromosome 10 (syntenic group U5). The identity between the human and bovine sequences is 97.8% at the amino acid level and 92% at the nucleotide level. The bovi...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1527

    authors: Tilstra DJ,Li L,Potter KA,Womack J,Byers PH

    更新日期:1994-09-15 00:00:00

  • A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.

    abstract::We completed a systematic survey of the human genome, conducted at an average resolution of 10 cM, for the identification of simple sequence tandem repeat polymorphisms (SSTRPs) that target new risk genes for Alzheimer disease (AD) by virtue of linkage disequilibrium. The efficiency of our association study was enhanc...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5306

    authors: Zubenko GS,Hughes HB,Stiffler JS,Hurtt MR,Kaplan BB

    更新日期:1998-06-01 00:00:00