Abstract:
:DNA methylation is a potential epigenetic mechanism that regulates genome stability, development, and stress mitigation in plants. It is mediated by cytosine-5 DNA methyltransferases (C5-MTases). We identified 52 wheat C5-MTases; and based on domain structure and phylogenetics, these 52 C5-MTases were classified into four sub-families including MET, CMT, DRM and DNMT2; and were distributed on 18 chromosomes. Cis-acting regulatory elements analysis identified abiotic stress-responsive, phytohormone-responsive, development-related and light-related elements in the promoters of TaC5-MTases. We also examined the transcript abundance of TaC5-MTases in different tissues, developmental stages and under abiotic stresses. Notably, most of the TaC5-MTases (TaCMT2, TaCMT3b, TaCMT3c, TaMET1, TaDRM10, TaDNMT2) showed differential regulation of their transcript abundance during drought and heat stress. Overall, the above results provide significant insights into the expression and the probable functions of TaC5-MTases and will also expedite future research programs to explore the mechanisms of epigenetic regulation in wheat.
journal_name
Genomicsjournal_title
Genomicsauthors
Gahlaut V,Samtani H,Khurana Pdoi
10.1016/j.ygeno.2020.08.031subject
Has Abstractpub_date
2020-11-01 00:00:00pages
4796-4807issue
6eissn
0888-7543issn
1089-8646pii
S0888-7543(20)30864-8journal_volume
112pub_type
杂志文章相关文献
GENOMICS文献大全abstract::FAT, a new member of the human cadherin super-family, has been isolated from the T-leukemia cell line J6. The predicted protein closely resembles the Drosophila tumor suppressor fat, which is essential for controlling cell proliferation during Drosophila development. The gene has the potential to encode a large transm...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.9884
更新日期:1995-11-20 00:00:00
abstract::The gene mutated in chorea-acanthocytosis (CHAC; approved gene symbol VPS13A) encodes chorein, a protein similar to yeast Vps13p. We detected several similar putative human proteins by BLAST analysis of chorein. We characterized the structure of three new genes encoding these CHAC-similar proteins, located on chromoso...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.04.012
更新日期:2004-09-01 00:00:00
abstract::To identify large proteins with an EGF-like-motif in a systematic manner, we developed a computer-assisted method called motif-trap screening. The method exploits 5'-end single-pass sequence data obtained from a pool of cDNAs whose sizes exceed 5 kb. Using this screening procedure, we were able to identify five known ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5341
更新日期:1998-07-01 00:00:00
abstract::Uroporphyrinogen-III (URO) synthase is the heme biosynthetic enzyme defective in congenital erythropoietic porphyria. The approximately 34-kb human URO-synthase gene (UROS) was isolated, and its organization and tissue-specific expression were determined. The gene had two promoters that generated housekeeping and eryt...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6373
更新日期:2000-12-01 00:00:00
abstract::N6-methyladenine (6mA) is one kind of post-replication modification (PTM or PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will be very helpful for revealing the biological functions of 6mA, but it is time-consuming and expensive to determine them by experiments alone. Unfortuna...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.01.005
更新日期:2019-01-01 00:00:00
abstract::Dynamins, microtubule-binding GTPases, are encoded by at least three genes in mammals. Two distinct gene-specific cDNAs were used to analyze the segregation of dynamin genes Dnm1 and Dnm2 in a mouse interspecies backcross. The nervous system-expressed gene Dnm1 was localized to Chr 2 between the genes for vimentin and...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4634
更新日期:1997-04-15 00:00:00
abstract::Syndactyly in Holstein cattle is an autosomal recessive abnormality characterized by the fusion of the functional digits. This disorder has been previously mapped to the telomeric part of bovine chromosome 15. Here, we describe the fine-mapping of syndactyly in Holstein cattle to a 3.5-Mb critical interval using a com...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.05.007
更新日期:2006-11-01 00:00:00
abstract::Acid sphingomyelinase (ASM; HGMW-approved symbol, SMPD1) is the lysosomal phosphodiesterase that hydrolyzes sphingomyelin to ceramide and phosphocholine. The deficient activity of this enzyme results in Types A and B Niemann-Pick disease (NPD). The full-length cDNA encoding human ASM has been isolated and characterize...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90366-z
更新日期:1992-02-01 00:00:00
abstract::lncRNAs are a class of transcriptional RNA molecules of >200 nucleotides in length. However, the overall expression pattern and function of lncRNAs in sheep muscle is not clear. Here, we identified 1566 lncRNAs and 404 differentially expressed lncRNAs in sheep muscle from prenatal (110 days of fetus) and postnatal (2 ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.01.009
更新日期:2019-03-01 00:00:00
abstract::MicroRNAs are small non-coding regulatory RNA molecules that play an important role in the modulation of gene expression during various environmental stresses. Pseudomonas putida RA, a plant growth promoting rhizobacteria (PGPR) colonizes the root surface of plants improving their growth and development during abiotic...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.01.007
更新日期:2019-07-01 00:00:00
abstract::LBR (lamin B receptor) is an integral protein of the inner nuclear membrane encoded by a gene on human chromosome 1q42.1. LBR has a nucleoplasmic, amino-terminal domain of approximately 200 amino acids followed by a carboxyl-terminal domain similar in sequence to yeast and plant sterol reductases. We have determined t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5615
更新日期:1998-12-15 00:00:00
abstract::Using antibodies directed against the amino-terminus of dystrophin, we identified a truncated protein in a Duchenne muscular dystrophy patient. Antibodies directed against the carboxy-terminus failed to identify any cross-reactive material, a result consistent with premature termination of dystrophin translation. The ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90332-9
更新日期:1991-06-01 00:00:00
abstract::The wealth of genomic technologies has enabled biologists to rapidly ascribe phenotypic characters to biological substrates. Central to effective biological investigation is the operational definition of the process under investigation. We propose an elucidation of categories of biological characters, including diseas...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.08.016
更新日期:2009-12-01 00:00:00
abstract::A comparison study of short SAGE versus GeneChip and long SAGE was conducted to determine if data were interchangeable between the techniques. Although SAGE and Affymetrix chip expression levels showed a significant correlation using the set of genes for which there was reliable and unambiguous mapping from tag-to-gen...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.06.014
更新日期:2004-10-01 00:00:00
abstract::The field of molecular evolution started with the alignment of a few protein sequences in the early 1960s. Among the first results found, the genetic equidistance result has turned out to be the most unexpected. It directly inspired the ad hoc universal molecular clock hypothesis that in turn inspired the neutral theo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2016.03.002
更新日期:2016-07-01 00:00:00
abstract::Multiple infections by HPV genotypes are frequently detected in HPV+ cervical lesions but the interaction between each viral genotype during carcinogenesis is poorly understood. Here we carried out a comprehensive study to characterize the multiple HPV expression and integration by RNA-seq analyses of 19 invasive cerv...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.05.009
更新日期:2020-09-01 00:00:00
abstract::This study has investigated the transcriptional regulation of the Emr1 gene in murine macrophages and defined an enhancer element within the proximal promoter that is necessary for Emr1 expression in myeloid cells. This element consists of an extended purine-rich sequence (PuRS) of 83 consecutive purine residues conta...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.08.016
更新日期:2004-12-01 00:00:00
abstract::The role of hyaluronan in cardiac growth has become evident, previously shown by increased myocardial levels of hyaluronan in a rat model of cardiac hypertrophy. To further investigate the role of hyaluronan and regulation of its synthesis in cardiac hypertrophy, quantitative measurements of myocardial hyaluronan conc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.04.003
更新日期:2010-08-01 00:00:00
abstract::During the course of systematic sequence tag analysis of clones isolated from an adult testis cDNA library, clones 296 and 576 were found to detect 71-74% sequence identity to the guinea pig sperm surface protein PH-20. This surface protein is involved in sperm-egg adhesion in the guinea pig. Nucleotide sequence for 1...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.9931
更新日期:1995-10-10 00:00:00
abstract::Deletion of the long arm of chromosome 6 (6q) is one of the most common chromosomal abnormalities in human hematological malignancies. Two distinct regions of minimal deletion have been identified by loss of heterozygosity studies at 6q25 to 6q27 (RMD-1) and at 6q21 to 6q23 (RMD-2), suggesting the presence of one or m...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5270
更新日期:1998-05-15 00:00:00
abstract::DNA 5' to the human myelin basic protein (MBP) gene, mapped to 18q22----qter, is known to manifest multiallelic DNA length variation with heterozygosity of at least 45%. Isolation of genomic DNA containing the MBP gene first exon and its 5' flanking region reveals that this polymorphism arises from a 994-bp region of ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90443-x
更新日期:1990-01-01 00:00:00
abstract::Small cell lung cancer (SCLC) has been associated with a deletion of the short arm of chromosome 3. One SCLC cell line, H748, has an interstitial deletion of chromosome 3p and shows allele loss for the DNF15S2 locus detected by the probe lambda H3. Conservation of DNF15S2 sequences in mouse indicated that this human g...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90342-x
更新日期:1989-04-01 00:00:00
abstract::Non-coding RNA is no longer considered to be "junk" DNA, based on evidence uncovered in recent decades. In particular, the important role played by natural antisense transcripts (NATs) in regulating the expression of genes is receiving increasing attention. However, the regulatory mechanisms of NATs remain incompletel...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.01.011
更新日期:2019-03-01 00:00:00
abstract::A human corneal fibroblast cDNA library was screened with a bovine lumican cDNA probe to obtain three clones. Sequencing of the longest clone (1.75 kb) yielded an open reading frame of 1014 bp coding for a 338-amino-acid core protein. Amino acid sequencing of a tryptic peptide resulted in a 9-amino-acid match with the...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1080
更新日期:1995-06-10 00:00:00
abstract::On the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacter...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00008-9
更新日期:2003-05-01 00:00:00
abstract::Cri-du-chat is a chromosomal deletion syndrome characterized by partial deletion of the short arm of chromosome 5. The clinical symptoms include growth and mental retardation, microcephaly, hypertelorism, epicanthal folds, hypotonia, and a high-pitched monochromatic cry that is usually considered diagnostic for the sy...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1582
更新日期:1994-11-01 00:00:00
abstract::We report the results of a chemogenomic profiling aimed to explore the mode of action of a quinolic analogue of the p300 histone acetyltransferase (HAT) inhibitor anacardic acid, named MC1626. This compound reduced histone H3 acetylation in a dose-dependent manner and the HATs Gcn5 and Rtt109, which specifically targe...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.08.005
更新日期:2010-11-01 00:00:00
abstract::Autosomal dominant polycystic kidney disease (PKD1) is linked to the alpha-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90198-2
更新日期:1992-05-01 00:00:00
abstract::We have analyzed the organization of the chicken alpha-globin gene domain using DNA miniarrays and have found two novel chromatin loop attachment regions. We have found a 40-kb loop domain that includes all the alpha-globin genes in cells of erythroid origin. One of the domain borders colocalizes almost exactly with a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.09.008
更新日期:2005-01-01 00:00:00
abstract::Several projects have produced maps of the physical position of genes within the human genome, either on a genome-wide scale or of a more detailed subsection of a chromosome. However, these maps largely rely on the mapping of expressed sequences (cDNAs and ESTs) back onto physical maps by their localization onto speci...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6075
更新日期:2000-02-01 00:00:00