Abstract:
:N6-methyladenine (6mA) is one kind of post-replication modification (PTM or PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will be very helpful for revealing the biological functions of 6mA, but it is time-consuming and expensive to determine them by experiments alone. Unfortunately, so far, no bioinformatics tool is available to do so. To fill in such an empty area, we have proposed a novel predictor called iDNA6mA-PseKNC that is established by incorporating nucleotide physicochemical properties into Pseudo K-tuple Nucleotide Composition (PseKNC). It has been observed via rigorous cross-validations that the predictor's sensitivity (Sn), specificity (Sp), accuracy (Acc), and stability (MCC) are 93%, 100%, 96%, and 0.93, respectively. For the convenience of most experimental scientists, a user-friendly web server for iDNA6mA-PseKNC has been established at http://lin-group.cn/server/iDNA6mA-PseKNC, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved.
journal_name
Genomicsjournal_title
Genomicsauthors
Feng P,Yang H,Ding H,Lin H,Chen W,Chou KCdoi
10.1016/j.ygeno.2018.01.005subject
Has Abstractpub_date
2019-01-01 00:00:00pages
96-102issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(18)30009-0journal_volume
111pub_type
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