Abstract:
:The role of hyaluronan in cardiac growth has become evident, previously shown by increased myocardial levels of hyaluronan in a rat model of cardiac hypertrophy. To further investigate the role of hyaluronan and regulation of its synthesis in cardiac hypertrophy, quantitative measurements of myocardial hyaluronan concentration was correlated to gene transcription in hypertrophic cardiac tissue. Factor analysis was used to study this correlation over time. A subset of differentially expressed genes was identified with a transcriptional regulation correlating to the increased synthesis of hyaluronan, suggesting a common regulatory pathway. Four transcription factors, Myc, Fos, Junb and Egr1, were also up-regulated. Furthermore, the Ace gene was up-regulated, representing increase of angiotensin II, an inducer of these transcription factors and fetal genes in cardiac hypertrophy. This demonstrates a coordinated synthesis of hyaluronan and pro-hypertrophic gene expression, regulated by immediate early genes, with angiotensin II as a possible mediator.
journal_name
Genomicsjournal_title
Genomicsauthors
Hellman U,Mörner S,Engström-Laurent A,Samuel JL,Waldenström Adoi
10.1016/j.ygeno.2010.04.003subject
Has Abstractpub_date
2010-08-01 00:00:00pages
73-81issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(10)00100-Xjournal_volume
96pub_type
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