Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1).

Abstract:

:Autosomal dominant polycystic kidney disease (PKD1) is linked to the alpha-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed alpha-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.

journal_name

Genomics

journal_title

Genomics

authors

Himmelbauer H,Pohlschmidt M,Snarey A,Germino GG,Weinstat-Saslow D,Somlo S,Reeders ST,Frischauf AM

doi

10.1016/0888-7543(92)90198-2

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

35-8

issue

1

eissn

0888-7543

issn

1089-8646

pii

0888-7543(92)90198-2

journal_volume

13

pub_type

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