Plant-pathogen interactions: MicroRNA-mediated trans-kingdom gene regulation in fungi and their host plants.

Abstract:

:MicroRNAs (miRNAs) have been prevalently studied in plants, animals, and viruses. However, recent studies show evidences of miRNA-like RNAs (milRNAs) in fungi as well. It is known that after successful infection, pathogens hijack the host machinery and use it for their own growth and multiplication. Alternatively, resistant plants can overcome the pathogen attack by a variety of mechanisms. Based on this prior knowledge, we computationally predicted milRNAs from 13 fungi, and identified their targets in transcriptomes of the respective fungi as well as their host plants. The expressions of the milRNAs and targets were confirmed using qRT-PCR. We found that plant miRNAs targeted fungal virulence genes, while fungal milRNAs targeted plant resistance genes; corroborating miRNA-mediated trans-kingdom gene regulation and the roles of miRNAs in plant-pathogen interactions. Transgenic plants with miRNAs targeting fungal virulence genes, or anti-sense of fungal milRNAs, would be expected to be highly resistant to the fungal pathogens.

journal_name

Genomics

journal_title

Genomics

authors

Mathur M,Nair A,Kadoo N

doi

10.1016/j.ygeno.2020.05.021

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

3021-3035

issue

5

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(19)30798-0

journal_volume

112

pub_type

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