Abstract:
:MicroRNAs (miRNAs) have been prevalently studied in plants, animals, and viruses. However, recent studies show evidences of miRNA-like RNAs (milRNAs) in fungi as well. It is known that after successful infection, pathogens hijack the host machinery and use it for their own growth and multiplication. Alternatively, resistant plants can overcome the pathogen attack by a variety of mechanisms. Based on this prior knowledge, we computationally predicted milRNAs from 13 fungi, and identified their targets in transcriptomes of the respective fungi as well as their host plants. The expressions of the milRNAs and targets were confirmed using qRT-PCR. We found that plant miRNAs targeted fungal virulence genes, while fungal milRNAs targeted plant resistance genes; corroborating miRNA-mediated trans-kingdom gene regulation and the roles of miRNAs in plant-pathogen interactions. Transgenic plants with miRNAs targeting fungal virulence genes, or anti-sense of fungal milRNAs, would be expected to be highly resistant to the fungal pathogens.
journal_name
Genomicsjournal_title
Genomicsauthors
Mathur M,Nair A,Kadoo Ndoi
10.1016/j.ygeno.2020.05.021subject
Has Abstractpub_date
2020-09-01 00:00:00pages
3021-3035issue
5eissn
0888-7543issn
1089-8646pii
S0888-7543(19)30798-0journal_volume
112pub_type
杂志文章相关文献
GENOMICS文献大全abstract::The wealth of genomic technologies has enabled biologists to rapidly ascribe phenotypic characters to biological substrates. Central to effective biological investigation is the operational definition of the process under investigation. We propose an elucidation of categories of biological characters, including diseas...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.08.016
更新日期:2009-12-01 00:00:00
abstract::MicroRNAs control gene expression at the posttranscriptional level by base-pairing to the 3'-UTR of their target mRNAs, thus leading to mRNA degradation of protein fabrication. We hypothesize, SNPs within miRNAs and their targets could be of significance to an individual's risk of developing cancer. We analyzed in sil...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2011.06.005
更新日期:2011-09-01 00:00:00
abstract::The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined. Northern blot analysis across a range of human tissues revealed that both the TADA2L and the GCN5L2 mRNAs are expressed to varying degrees in all tissue types. Furthermore, in most...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4605
更新日期:1997-03-15 00:00:00
abstract::The gene for X-linked nephrogenic diabetes insipidus (NDI), a disorder which, if untreated, causes severe dehydration, mental retardation, and possibly death in affected males, has been mapped recently to the Xq28 band through demonstration of linkage to the DX552 locus and other DNA markers (N. Knoers et al., 1987, C...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90352-2
更新日期:1989-04-01 00:00:00
abstract::The genes encoding receptors for the chemotactic ligands C5a (C5AR) and FMLP (FPR) were mapped using a panel of somatic cell hybrids to chromosome 19. Because the hybridization pattern on Southern analysis suggested an intron structure or related genes in the case of FPR, genomic clones were characterized. Two structu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90265-t
更新日期:1992-06-01 00:00:00
abstract::We have mapped 13 loci on mouse Chromosome 18 by Southern blot analysis of restriction fragment length polymorphisms among progeny from an interspecific backcross: (C57BL/6J X Mus spretus) X M. spretus. Complete haplotype analysis of 136 of these progeny was used to establish gene order and estimate genetic distances ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90029-r
更新日期:1992-08-01 00:00:00
abstract::Mutations in the FBN1 gene, encoding the extracellular matrix protein fibrillin-1, result in the dominant connective tissue disease Marfan syndrome. Marfan syndrome has a variable phenotype, even within families carrying the same FBN1 mutation. Differences in gene expression resulting from sequence differences in the ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.06.005
更新日期:2009-10-01 00:00:00
abstract::Human genomic mapping has been greatly advanced by the independent development of three new methods: large DNA fragment cloning in yeast artificial chromosomes, amplification from complex DNAs of human specific segments by Alu-PCR, and high-resolution localization of complex DNA probes by fluorescent in situ hybridiza...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90148-l
更新日期:1992-07-01 00:00:00
abstract::During the course of systematic sequence tag analysis of clones isolated from an adult testis cDNA library, clones 296 and 576 were found to detect 71-74% sequence identity to the guinea pig sperm surface protein PH-20. This surface protein is involved in sperm-egg adhesion in the guinea pig. Nucleotide sequence for 1...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.9931
更新日期:1995-10-10 00:00:00
abstract::We have previously reported that the expression of HC gp-39, a 39-kDa secretory glycoprotein and member of the chitinase protein family, is associated with late stages of monocyte to macrophage maturation. To allow further investigations of its unique expression pattern and to facilitate studies on the regulation of t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4778
更新日期:1997-07-15 00:00:00
abstract::Afrotheria genome size is reported to be over 50% larger than that of human, but we show that this is a gross overestimate. Although genome sequencing in Afrotheria is not complete, extensive homology with human has been revealed by chromosome painting. We provide new data on chromosome size and GC content in four Afr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2013.09.002
更新日期:2013-11-01 00:00:00
abstract::One of the important goals in systems biology is to infer transcription network based on gene expression data. Validation of the reconstructed network often requires benchmark datasets, e.g. gene expression data, which are usually unattainable. Synthetic datasets are therefore often needed to test the structure learni...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.08.009
更新日期:2009-11-01 00:00:00
abstract::Hemizygous deletions on chromosome 22q11.2 result in developmental disorders referred to as DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS). We report the isolation of a novel gene, PCQAP (PC2 glutamine/Q-rich-associated protein), that maps to the DiGeorge typically deleted region and encodes a protein identi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2001.6566
更新日期:2001-06-15 00:00:00
abstract::We have isolated cDNA clones that code for human cytochrome b5. Owing to the high degree of evolutionary conservation of cytochrome b5 sequences and the existence of human and rodent cytochrome b5 processed pseudogenes, we were unable to map unambiguously the chromosomal localization of the human gene(s) by Southern b...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90136-3
更新日期:1991-10-01 00:00:00
abstract::We employed the polymerase chain reaction and genomic DNA library screening to clone novel human genes, GPR9 and GPR10, and a rat gene, GPR14. GPR9, GPR10, and GPR14 each encode G protein-coupled receptors. GPR10 and GPR14 are intronless within their coding regions, while GPR9 contains at least one intron. The recepto...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.9996
更新日期:1995-09-20 00:00:00
abstract::Consecutive application of PCR and serial analysis of gene expression (SAGE) was used to generate a catalog of approximately 50, 000 SAGEtags from nine human oocytes. Matches for known genes were identified using the National Institutes of Health SAGEtag database. This database links directly to the UniGene database, ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6059
更新日期:2000-01-01 00:00:00
abstract::Formyl peptide receptors (FPRs) were firstly detected in immune cells where they act as key mediators of leukocyte chemotaxis, promoting the host defense against pathogens. Recently, three paralogs were reported in Homo sapiens (FPR1-3) and seven paralogs in Mus musculus (FPR1, FPRrs1-4, FPRrs6 and FPRrs7), but inform...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.03.015
更新日期:2020-07-01 00:00:00
abstract::A gene family of Na+/H+ exchanger isoforms has been identified. Characterization of rabbit NHE3 suggests that it is the apical epithelial Na+/H+ exchanger isoform responsible for transepithelial, electroneutral Na+ absorption in intestinal and renal epithelial cells. We have previously isolated from a human kidney cor...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1122
更新日期:1993-03-01 00:00:00
abstract::The major histocompatibility complex (MHC) class I region has been shown to be associated with a variety of immune and nonimmune disorders. In an effort to initiate steps designed to identify the idiopathic hemochromatosis disease gene (HFE), we have cloned and mapped two expressed messages using probes from the HLA-H...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1382
更新日期:1994-07-15 00:00:00
abstract::The chromosomal abnormality represented by an isodicentric X chromosome [idic(X)(q13)] is associated with a subset of acute myeloid leukemia (AML) and preleukemia observed in elderly females. A previous study localized the breakpoints of two acquired isodicentric X chromosomes associated with myelodysplasia to a 450-k...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6128
更新日期:2000-03-15 00:00:00
abstract::Comparative genetic analysis between human and chimpanzee may detect genetic divergences responsible for human-specific characteristics. Previous studies have identified a series of genes that potentially underwent Darwinian positive selection during human evolution. However, without a closely related species as outgr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.05.008
更新日期:2006-12-01 00:00:00
abstract::The Friedreich's ataxia locus has been previously assigned to chromosome 9q 13-21.1 by the demonstration of tight linkage to two anonymous DNA markers. MCT112 (Z greater than 80, theta = 0) and DR47 (Z greater than 50, theta = 0). The absence of recombination between these three loci has prevented the resolution of ge...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90224-3
更新日期:1991-01-01 00:00:00
abstract::The spectrum of cystic fibrosis (CF) mutations was determined in 105 patients by using denaturing gradient gel electrophoresis to screen the entire coding regions and adjacent cystic fibrosis transmembrane conductance regulator (CFTR) gene sequences. The nucleotide substitutions detected included 16 novel mutations, 1...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90152-i
更新日期:1992-07-01 00:00:00
abstract::The proximal end of mouse chromosome (Chr) 13 contains regions conserved on human chromosomes 1q42-q44, 6p23-p21, and 7p22-p13. This region also contains mutations that may be models for human disease, including beige (human Chediak-Higashi syndrome). An interspecific backcross of SB/Le and Mus spretus mice was used t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4478
更新日期:1997-01-15 00:00:00
abstract::Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somat...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1372
更新日期:1993-09-01 00:00:00
abstract::Changing bovine milk fatty acid (FA) composition through selection can decrease saturated FA (SFA) consumption, improve human health and provide a means for manipulating processing properties of milk. Our study determined associations between milk FA composition and genes from triacylglycerol (TAG) biosynthesis pathwa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2014.10.001
更新日期:2014-12-01 00:00:00
abstract::Southern blot analysis of genomic DNA from different strains of rat indicated that there were multiple copies of the gene encoding the second enzyme of the heme biosynthetic pathway, delta-aminolevulinate dehydratase (ALA-D). Two types of genomic clones were isolated from a Sprague-Dawley rat library. One appears to b...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90210-l
更新日期:1990-08-01 00:00:00
abstract::A novel gene, TEGT (testis enhanced gene transcript), has been identified in humans. It does not belong to any known gene family of vertebrates. The deduced amino acid sequence of the gene and a bacterial protein of unknown function show low but significant homology and very similar hydrophobicity profiles. Two differ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1145
更新日期:1995-07-20 00:00:00
abstract::Pancreatitis-associated protein (PAP) is a secretory pancreatic protein present in small amounts in normal pancreas and overexpressed during the acute phase of the pancreatitis. In this paper, we describe the cloning, characterization, and chromosomal mapping of the human PAP gene. The gene spans 2748 bp and contains ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1019
更新日期:1994-01-01 00:00:00
abstract::Differences in the methylation status of certain cytosine residues between active and inactive X chromosomes can be used to determine X-inactivation in females heterozygous for X-linked restriction fragment length polymorphisms. We have studied methylation patterns in 105 females heterozygous at the DXS255 locus by So...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(05)80285-x
更新日期:1992-09-01 00:00:00