Abstract:
:Bacillus spp. play important roles in production of bioactive natural products with potential agricultural and medical applications. The three families of lipopeptides produced by Bacillus spp. have been most recognized for their antagonistic activity against other microbes, i.e. fengycin, iturin, and surfactin. A novel strain NST6 was isolated from soil and identified as B. velezensis based on phylogenomic analysis. Genome analysis revealed 21 putative biosynthetic gene clusters including the ones responsible for producing bacillomycin and surfactin. However, fengycin cluster was compromised with absence or partial disruption of three non-ribosomal peptide synthetases. Distribution of biosynthetic gene clusters showed that clusters for iturin families were well conserved in 327 genomes of the species belonging to the operational group B. amyloliquefaciens. However, clusters for fengycin and surfactin showed dynamic distribution at gene level. Comparative analysis of closely related species would provide new insights to the diversity in genetic elements for secondary metabolites.
journal_name
Genomicsjournal_title
Genomicsauthors
Choi J,Nam J,Seo MHdoi
10.1016/j.ygeno.2020.12.011subject
Has Abstractpub_date
2021-01-01 00:00:00pages
380-386issue
1 Pt 1eissn
0888-7543issn
1089-8646pii
S0888-7543(20)32055-3journal_volume
113pub_type
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