Abstract:
:The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as certain imprinted genes are known to have altered imprinting phenotypes in cancer. Of 14 breast samples demonstrating a MAS RT-PCR product, 4 were informative for a polymorphic marker. In all 4 cases, expression of the MAS gene was found to be mono-allelic, indicating the presence of a functional imprint at this locus in human breast tissue.
journal_name
Genomicsjournal_title
Genomicsauthors
Miller N,McCann AH,O'Connell D,Pedersen IS,Spiers V,Gorey T,Dervan PAdoi
10.1006/geno.1997.5063subject
Has Abstractpub_date
1997-12-15 00:00:00pages
509-12issue
3eissn
0888-7543issn
1089-8646pii
S0888-7543(97)95063-1journal_volume
46pub_type
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