Abstract:
:Pancreatitis-associated protein (PAP) is a secretory pancreatic protein present in small amounts in normal pancreas and overexpressed during the acute phase of the pancreatitis. In this paper, we describe the cloning, characterization, and chromosomal mapping of the human PAP gene. The gene spans 2748 bp and contains six exons interrupted by five introns. The gene has a typical promoter containing the sequences TATAAA and CCAAT 28 and 52 bp upstream of the cap site, respectively. We found striking similarities in genomic organization as well as in the promoter sequences between the human and rat PAP genes. The human PAP gene was mapped to chromosome 2p12 using rodent-human hybrid cells and in situ chromosomal hybridization. This localization coincides with that of the reg/lithostathine gene, which encodes a pancreatic secretory protein structurally related to PAP, suggesting that both genes derived from the same ancestral gene by duplication.
journal_name
Genomicsjournal_title
Genomicsauthors
Dusetti NJ,Frigerio JM,Fox MF,Swallow DM,Dagorn JC,Iovanna JLdoi
10.1006/geno.1994.1019subject
Has Abstractpub_date
1994-01-01 00:00:00pages
108-14issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(84)71019-6journal_volume
19pub_type
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