当前位置： SCI文献检索 > GENOMICS期刊下所有文献 > Fructose-1,6-bisphosphatase: genetic and physical mapping to human chromosome 9q22.3 and evaluation in non-insulin-dependent diabetes mellitus.

Fructose-1,6-bisphosphatase: genetic and physical mapping to human chromosome 9q22.3 and evaluation in non-insulin-dependent diabetes mellitus.

Abstract：

:PCR primers specific to the human liver fructose-1,6-bisphosphatase (FBP) gene were designed and used to isolate a cosmid clone. Physical mapping of the FBP cosmid by FISH, and genetic mapping of an associated GA repeat polymorphism (PIC = 0.35), located the liver FBP gene to chromosome 9q22.3 with no recombination between FBP and the index markers D9S196 (Zmax = 13.2), D9S280 (Zmax = 11.7), D9S287 (Zmax = 15.6), and D9S176 (Zmax = 14.4). Amplification using FBP exon-specific primers with a YAC contig from this region of chromosome 9 further refined the placement of FBP genomic sequences to an approximately 1.7-cM region flanked by D9S280 and D9S287, near the gene for Fanconi anemia group C. Precise localization of the FBP gene enabled evaluation of FBP as a candidate gene for maturity-onset diabetes of the young (MODY) and non-insulin-dependent diabetes (NIDDM) in both Caucasian and African-American families, using the highly informative markers D9S287 and D9S176. Although FBP is a rate-limiting enzyme in gluconeogenesis, using both parametric and nonparametric analysis there was no evidence for linkage of FBP to diabetes in these families.

journal_name

Genomics

journal_title

Genomics

authors

Rothschild CB,Freedman BI,Hodge R,Rao PN,Pettenati MJ,Anderson RA,Akots G,Qadri A,Roh B,Fajans SS

doi

10.1006/geno.1995.1230

subject

Has Abstract,Author List Incomplete

pub_date

1995-09-01 00:00:00

pages

187-94

issue

1

eissn

0888-7543

issn

1089-8646

pii

S088875438571230X

journal_volume

29

pub_type

杂志文章

相关文献

GENOMICS文献大全
  • Diversity analysis at MHC class II DQA locus in buffalo (Bubalus bubalis) indicates extensive duplication and trans-species evolution.

    abstract：:Variation at MHC Class II-DQA locus in riverine and swamp buffaloes (Bubu) has been explored in this study. Through sequencing of buffalo DQA, 48 nucleotide variants identified from 17 individuals, reporting 42 novel alleles, including one pseudogene. Individual animal displayed two to seven variants, suggesting the p...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2020.07.041

    authors： Mishra SK,Niranjan SK,Singh R,Kumar P,Kumar SL,Banerjee B,Kataria RS

    更新日期：2020-11-01 00:00:00

  • Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins.

    abstract：:RIMs are synaptic proteins that are essential for normal neurotransmitter release. We now show that while invertebrates contain only a single RIM gene, vertebrates contain four: two large genes encoding RIM1alpha (0.50 Mb) or RIM2alpha, 2beta, and 2gamma (0.50-0.75 Mb) and two smaller genes encoding RIM3gamma (14 kb) ...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/s0888-7543(02)00024-1

    authors： Wang Y,Südhof TC

    更新日期：2003-02-01 00:00:00

  • Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system.

    abstract：:The TPD52 (tumor protein D52)-like proteins are small coiled-coil motif-bearing proteins which were first identified though their expression in human breast carcinoma. TPD52-like proteins are known to interact in hetero-and homomeric fashions, but there are no known heterologous binding partners for these proteins. We...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.2001.6610

    authors： Wilson SH,Bailey AM,Nourse CR,Mattei MG,Byrne JA

    更新日期：2001-08-01 00:00:00

  • Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages.

    abstract：:This study has investigated the transcriptional regulation of the Emr1 gene in murine macrophages and defined an enhancer element within the proximal promoter that is necessary for Emr1 expression in myeloid cells. This element consists of an extended purine-rich sequence (PuRS) of 83 consecutive purine residues conta...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2004.08.016

    authors： O'Reilly D,Addley M,Quinn C,MacFarlane AJ,Gordon S,McKnight AJ,Greaves DR

    更新日期：2004-12-01 00:00:00

  • Genomic analysis of racial differences in triple negative breast cancer.

    abstract：:Triple negative breast cancer (TNBC) is more prevalent in African Americans (AAs), has a more aggressive clinical course including a higher mortality rate and an increased occurrence of metastases. This study was designed to determine if racial differences at the molecular level might explain the more aggressive pheno...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2018.10.010

    authors： Chang CS,Kitamura E,Johnson J,Bollag R,Hawthorn L

    更新日期：2019-12-01 00:00:00

  • The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome.

    abstract：:Forty-three sequences containing simple sequence repeats or microsatellites were generated from an M13 library of total genomic mouse DNA. These sequences were analyzed for size variation using the polymerase chain reaction and gel electrophoresis without the need for radiolabeling. Seventy-two percent of the sequence...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/0888-7543(91)90175-e

    authors： Cornall RJ,Aitman TJ,Hearne CM,Todd JA

    更新日期：1991-08-01 00:00:00

  • Maternal and paternal chromosomes 7 show differential methylation of many genes in lymphoblast DNA.

    abstract：:Genomic imprinting, the differential expression of paternal and maternal alleles, involves many chromosomal regions and plays a role in development and growth. Differential methylation of maternal and paternal alleles is a hallmark of imprinted genes, and thus methylation assays are widely used to support the identifi...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.2001.6502

    authors： Hannula K,Lipsanen-Nyman M,Scherer SW,Holmberg C,Höglund P,Kere J

    更新日期：2001-04-01 00:00:00

  • Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

    abstract：:The human DAZ (deleted in azoospermia) gene family on the Y chromosome and an autosomal DAZ-like gene, DAZL1, encode RNA-binding proteins that are expressed exclusively in germ cells. Their role in spermatogenesis is supported by their homology with a Drosophila male infertility gene boule and sterility of Daz11 knock...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.2000.6169

    authors： Tsui S,Dai T,Roettger S,Schempp W,Salido EC,Yen PH

    更新日期：2000-05-01 00:00:00

  • Linkage relations between A2M, HOX3, INT1, KRAS2, and PAH on bovine chromosome 5.

    abstract：:There is a high level of conservation between human chromosomes and bovine syntenic groups. One such comparison is between human chromosome 12 and bovine chromosome 5, where at least 16 loci have been shown to be conserved in an homologous segment. However, the degree of conservation of order of the loci on bovine chr...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/s0888-7543(05)80280-0

    authors： Barendse W,Armitage SM,Womack JE,Hetzel J

    更新日期：1992-09-01 00:00:00

  • Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China.

    abstract：:In this study, we systematically screened the polymorphisms of the whole CYP2D6 gene in the populations of four different geographical locations in China, namely, Shanghai, Shantou, Shenyang, and Xi'an, using a sample of 100 subjects from each population. Forty-eight different polymorphisms were detected as well as 12...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2008.05.004

    authors： Qin S,Shen L,Zhang A,Xie J,Shen W,Chen L,Tang J,Xiong Y,Yang L,Shi Y,Feng G,He L,Xing Q

    更新日期：2008-09-01 00:00:00

  • Genomic organization of the human lysosomal acid lipase gene (LIPA).

    abstract：:Defects in the human lysosomal acid lipase gene are responsible for cholesteryl ester storage disease (CESD) and Wolman disease. Exon skipping as the cause for CESD has been demonstrated. We present here a summary of the exon structure of the entire human lysosomal acid lipase gene consisting of 10 exons, together wit...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.1994.1180

    authors： Aslanidis C,Klima H,Lackner KJ,Schmitz G

    更新日期：1994-03-15 00:00:00

  • The boundary of macaque rDNA is constituted by low-copy sequences conserved during evolution.

    abstract：:In Macaca mulatta, the single rDNA array is flanked by a patchwork of sequences including subregions of human Yp11.2, 4q35.2, and 10p15.3. This composite DNA region is characterized by unique or low-copy sequences, resembling a potentially transcribed region. The analysis of Cercopithecus aethiops, Presbytis cristata,...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2006.05.001

    authors： Bodega B,Cardone MF,Rocchi M,Meneveri R,Marozzi A,Ginelli E

    更新日期：2006-11-01 00:00:00

  • Pathogenic 12-kb copy-neutral inversion in syndromic intellectual disability identified by high-fidelity long-read sequencing.

    abstract：:We report monozygotic twin girls with syndromic intellectual disability who underwent exome sequencing but with negative pathogenic variants. To search for variants that are unrecognized by exome sequencing, high-fidelity long-read genome sequencing (HiFi LR-GS) was applied. A 12-kb copy-neutral inversion was precisel...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2020.10.038

    authors： Mizuguchi T,Okamoto N,Yanagihara K,Miyatake S,Uchiyama Y,Tsuchida N,Hamanaka K,Fujita A,Miyake N,Matsumoto N

    更新日期：2020-11-04 00:00:00

  • Early and transient gene expression changes in pressure overload-induced cardiac hypertrophy in mice.

    abstract：:Cardiac hypertrophy is an important risk factor for cardiac morbidity and mortality. To unravel the underlying pathogenic genetic pathways, we hybridized left ventricular RNA from Transverse Aortic Constriction mice at 48 h, 1 week, and 2, 3, and 8 weeks after surgery to microarrays containing a 15K fetal cDNA collect...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2006.04.012

    authors： van den Bosch BJ,Lindsey PJ,van den Burg CM,van der Vlies SA,Lips DJ,van der Vusse GJ,Ayoubi TA,Doevendans PA,Smeets HJ

    更新日期：2006-10-01 00:00:00

  • Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay.

    abstract：:Specific language impairment (SLI) is defined as failure to acquire normal language skills despite adequate intelligence and environmental stimulation. Although SLI disorders are often heritable, the genetic basis is likely to involve a number of risk factors. This study describes a 7-year-old girl carrying an inherit...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2005.04.002

    authors： Kwasnicka-Crawford DA,Carson AR,Roberts W,Summers AM,Rehnström K,Järvelä I,Scherer SW

    更新日期：2005-08-01 00:00:00

  • Retrotransposon insertions in rice gene pairs associated with reduced conservation of gene pairs in grass genomes.

    abstract：:Small-scale changes in gene order and orientation are common in plant genomes, even across relatively short evolutionary distances. We investigated the association of retrotransposons in and near rice gene pairs with gene pair conservation, inversion, rearrangement, and deletion in sorghum, maize, and Brachypodium. Co...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2012.02.006

    authors： Krom N,Ramakrishna W

    更新日期：2012-05-01 00:00:00

  • Mutation identification of the DSPP in a Chinese family with DGI-II and an up-to-date bioinformatic analysis.

    abstract：:In this study, through linkage analysis of a four-generation Chinese family with multiple members afflicted with DGI (type II), we identified a novel missense mutation in DSPP. The mutation was located in exon 2 at the second nucleotide position of the last codon and resulted in a substitution of a proline with a leuc...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2012.01.006

    authors： Li D,Du X,Zhang R,Shen B,Huang Y,Valenzuela RK,Wang B,Zhao H,Liu Z,Li J,Xu Z,Gao L,Ma J

    更新日期：2012-04-01 00:00:00

  • Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.

    abstract：:We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insuli...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.2001.6647

    authors： McCarthy LC,Hosford DA,Riley JH,Bird MI,White NJ,Hewett DR,Peroutka SJ,Griffiths LR,Boyd PR,Lea RA,Bhatti SM,Hosking LK,Hood CM,Jones KW,Handley AR,Rallan R,Lewis KF,Yeo AJ,Williams PM,Priest RC,Khan P,Donnelly

    更新日期：2001-12-01 00:00:00

  • Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.

    abstract：:Aberrant DNA methylation is induced at specific promoter CpG islands (CGIs) in contrast with mutations. The specificity is influenced by genome architecture and epigenetic factors, but their relationship is still unknown. In this study, we isolated promoter CGIs susceptible and resistant to aberrant methylation induct...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2011.06.003

    authors： Takeshima H,Yamashita S,Shimazu T,Ushijima T

    更新日期：2011-09-01 00:00:00

  • Inactive allele-specific methylation and chromatin structure of the imprinted gene U2af1-rs1 on mouse chromosome 11.

    abstract：:The imprinted U2af1-rs1 gene that maps to mouse chromosome 11 is predominately expressed from the paternal allele. We examined the methylation of genomic sequences in and around the U2af1-rs1 locus to establish the extent of sequence modifications that accompanied the silencing of the maternal allele. The analysis of ...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.1996.0348

    authors： Shibata H,Yoshino K,Sunahara S,Gondo Y,Katsuki M,Ueda T,Kamiya M,Muramatsu M,Murakami Y,Kalcheva I,Plass C,Chapman VM,Hayashizaki Y

    更新日期：1996-07-01 00:00:00

  • Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization.

    abstract：:Sulfonation is an important pathway in the biotransformation of many drugs, xenobiotics, neurotransmitters, and steroid hormones. The thermostable (TS) form of phenol sulfotransferase (PST) preferentially catalyzes the sulfonation of "simple" planar phenols, and levels of activity of TS PST in human tissues are contro...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.1996.0216

    authors： Her C,Raftogianis R,Weinshilboum RM

    更新日期：1996-05-01 00:00:00

  • Synteny mapping in the bovine: genes from human chromosome 4.

    abstract：:Genes homologous to those located on human chromosome 4 (HSA4) were mapped in the bovine to determine regions of syntenic conservation among humans, mice, and cattle. Previous studies have shown that two homologs of genes on HSA4, PGM2 and PEPS, are located in bovine syntenic group U15 (chromosome 6). The homologous m...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/s0888-7543(05)80295-2

    authors： Zhang N,Threadgill DW,Womack JE

    更新日期：1992-09-01 00:00:00

  • Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library.

    abstract：:A large insert canine genomic bacterial artificial chromosome (BAC) library was built from a Doberman pinscher. Approximately 166,000 clones were gridded on nine high-density hybridization filters. Insert analysis of randomly selected clones indicated a mean insert size of 155 kb and predicted 8.1 coverage of the cani...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.1999.5772

    authors： Li R,Mignot E,Faraco J,Kadotani H,Cantanese J,Zhao B,Lin X,Hinton L,Ostrander EA,Patterson DF,de Jong PJ

    更新日期：1999-05-15 00:00:00

  • A 9.1-kb gap in the genome reference map is shown to be a stable deletion/insertion polymorphism of ancestral origin.

    abstract：:We show a mute 9.1-kb gap in the human genome reference map, unraveled by RDA studies, to be a worldwide deletion/insertion polymorphism of stable type. The molecular and population data presented suggest its origin from a unique ancestral transposition event in chromosomal region 22q11.2, overlapping the IglambdaV ge...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.2002.7014

    authors： Robledo R,Orru S,Sidoti A,Muresu R,Esposito D,Grimaldi MC,Carcassi C,Rinaldi A,Bernini L,Contu L,Romani M,Roe B,Siniscalco M

    更新日期：2002-12-01 00:00:00

  • MetaCAA: A clustering-aided methodology for efficient assembly of metagenomic datasets.

    abstract：:A key challenge in analyzing metagenomics data pertains to assembly of sequenced DNA fragments (i.e. reads) originating from various microbes in a given environmental sample. Several existing methodologies can assemble reads originating from a single genome. However, these methodologies cannot be applied for efficient...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2014.02.007

    authors： Reddy RM,Mohammed MH,Mande SS

    更新日期：2014-02-01 00:00:00

  • A single segment substitution line population for identifying traits relevant to drought tolerance and avoidance.

    abstract：:A population of chromosome segment substitution lines was developed using KDML105 as the recurrent parent and one of DH212 (IR68586-F2-CA-143) or DH103 (IR68586-F2-CA-31) as the donor parent. The donor parents are part of a doubled haploid population from a cross between CT9993, an upland japonica accession, and IR622...

    journal_title：Genomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygeno.2019.10.001

    authors： Shearman JR

    更新日期：2019-10-31 00:00:00

  • Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection.

    abstract：:Denaturing high-performance liquid chromatography (DHPLC) is a novel high-capacity technique for detecting new mutations. We have evaluated the sensitivity and specificity of this method in a blind analysis of exon H of the factor IX gene and exon 16 of the neurofibromatosis type 1 gene. Under a single set of conditio...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1006/geno.1998.5411

    authors： O'Donovan MC,Oefner PJ,Roberts SC,Austin J,Hoogendoorn B,Guy C,Speight G,Upadhyaya M,Sommer SS,McGuffin P

    更新日期：1998-08-15 00:00:00

  • Retroposon compensatory mechanism hypothesis not supported: Zfa knockout mice are fertile.

    abstract：:It is hypothesized that autosomal retroposons compensate for the loss of their inactivated essential X-chromosome progenitors during spermatogenesis. Here we test this Retroposon Compensatory Mechanism (RCM) hypothesis using the Zfy gene family. The mouse autosomal retroposon Zfa is expressed in testes at the same dev...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/s0888-7543(03)00155-1

    authors： Banks KG,Johnson KA,Lerner CP,Mahaffey CL,Bronson RT,Simpson EM

    更新日期：2003-09-01 00:00:00

  • Transcriptional regulation in eukaryotic ribosomal protein genes.

    abstract：:Understanding ribosomal protein gene regulation provides a good avenue for understanding gene regulatory networks. Even after 5 decades of research on ribosomal protein gene regulation, little is known about how higher eukaryotic ribosomal protein genes are coordinately regulated at the transcriptional level. However,...

    journal_title：Genomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygeno.2007.07.003

    authors： Hu H,Li X

    更新日期：2007-10-01 00:00:00

  • Identification of small non-coding RNAs in the planarian Dugesia japonica via deep sequencing.

    abstract：:Freshwater planarian flatworm possesses an extraordinary ability to regenerate lost body parts after amputation; it is perfect organism model in regeneration and stem cell biology. Recently, small RNAs have been an increasing concern and studied in many aspects, including regeneration and stem cell biology, among othe...

    journal_title：Genomics

    pub_type： 杂志文章

    doi：10.1016/j.ygeno.2012.03.001

    authors： Qin YF,Zhao JM,Bao ZX,Zhu ZY,Mai J,Huang YB,Li JB,Chen G,Lu P,Chen SJ,Su LL,Fang HM,Lu JK,Zhang YZ,Zhang ST

    更新日期：2012-05-01 00:00:00