Abstract:
:Triple negative breast cancer (TNBC) is more prevalent in African Americans (AAs), has a more aggressive clinical course including a higher mortality rate and an increased occurrence of metastases. This study was designed to determine if racial differences at the molecular level might explain the more aggressive phenotype in AAs. Mutation profiling, was performed on 51 AA and 77 CA tumor/ normal pairs. Transcript expression analysis was performed on 35AA and 37CA. Genes with high frequency mutation rates such as MUC4 and TP53 were common to both racial populations, however genes that were less frequently mutated differed between the races suggesting that those cause the more aggressive nature of TNBC in AA women. JAK-Stat and HER2 signaling were unique to the AA and PTEN and mTOR were unique to the CA profiles. Many pathways identified by the mutational profiles were predicted to be down-regulated by the transcript expression profiles.
journal_name
Genomicsjournal_title
Genomicsauthors
Chang CS,Kitamura E,Johnson J,Bollag R,Hawthorn Ldoi
10.1016/j.ygeno.2018.10.010subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1529-1542issue
6eissn
0888-7543issn
1089-8646pii
S0888-7543(18)30045-4journal_volume
111pub_type
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