Abstract:
:In humans, uridine 5'-diphosphate glucuronosyltransferase (UGT) operates in opposition to glucuronidase (GUS) to control activity of diverse metabolites such as hormones by reversible conjugation with glucuronic acid. Previous data revealed that, as in mammals, these enzymes are required for plant life in that a UGT from Pisum sativum (PsUGT1) controls plant development by opposing endogenous GUS activity thereby modulating the duration of the cell cycle. Here we report that a small family of genes (AtUGT85A1, 2, 3, 4, 5, and 7) homologous to pea PsUGT1 exists in the Arabidopsis genome. The AtUGT85A-encoded proteins are predicted to be membrane-associated enzymes. Three genes (AtGUS1, AtGUS2, and AtGUS3) that are homologous to a GUS-encoding gene from Scutellaria baicalensis were identified. The AtGUS-encoded proteins are predicted to be secretory (AtGUS1) and membrane-associated (AtGUS2 and AtGUS3) enzymes. Both AtUGT85A and AtGUS genes, like PsUGT1, exhibit localized, tissue-specific expression, mainly in areas of active cell division with possible involvement in cell cycle regulation.
journal_name
Genomicsjournal_title
Genomicsauthors
Woo HH,Jeong BR,Hirsch AM,Hawes MCdoi
10.1016/j.ygeno.2007.03.014subject
Has Abstractpub_date
2007-07-01 00:00:00pages
143-53issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(07)00071-7journal_volume
90pub_type
杂志文章相关文献
GENOMICS文献大全abstract::The ST2 gene is a member of the IL-1 receptor family and is hypothesized to be involved in helper T cell function, but its functional ligand and physiological role remain unknown. We have cloned the human ST2L cDNA that encodes a distinct type of membrane-bound ST2 protein. The predicted 556-amino-acid sequence showed...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6269
更新日期:2000-08-01 00:00:00
abstract::We have isolated and chromosomally fine-mapped 16 novel genes belonging to the human zinc finger Krüppel family (ZNF131-140, 142, 143, 148, 151, 154, and 155), including 1 of the GLI type (ZNF143) and 3 containing a KRAB (Krüppel-associated box) segment (ZNF133, 136, and 140). Based on their map position, several of t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1040
更新日期:1995-05-20 00:00:00
abstract::Proprotein convertase 4 (PC4) is a mammalian secretory serine endoproteinase similar to the yeast KEX2 gene product and specifically expressed in testicular germs cells. PC4 mRNA isoforms that vary in size and 3' coding sequence have been reported (N. G. Seitah, R. Day, J. Hamelin, A. Gaspar, M. W. Collard, and M. Chr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1158
更新日期:1994-03-15 00:00:00
abstract::Spatiotemporal expression of the PAX3 gene is tightly regulated during development. We have isolated and sequenced the 5'-flanking regulatory region of human PAX3. Primer extension and ribonuclease protection mapping revealed that transcription is initiated from a single start site downstream of a TATA-like motif in h...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5711
更新日期:1999-04-01 00:00:00
abstract::We show a mute 9.1-kb gap in the human genome reference map, unraveled by RDA studies, to be a worldwide deletion/insertion polymorphism of stable type. The molecular and population data presented suggest its origin from a unique ancestral transposition event in chromosomal region 22q11.2, overlapping the IglambdaV ge...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.7014
更新日期:2002-12-01 00:00:00
abstract::The imprinted U2af1-rs1 gene that maps to mouse chromosome 11 is predominately expressed from the paternal allele. We examined the methylation of genomic sequences in and around the U2af1-rs1 locus to establish the extent of sequence modifications that accompanied the silencing of the maternal allele. The analysis of ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0348
更新日期:1996-07-01 00:00:00
abstract::We have established a method for amplifying and obtaining large quantities of chromosome-specific DNA by linker/adaptor ligation and polymerase chain reaction (PCR). Small quantities of DNA isolated from flow cytometry-sorted chromosomes 17 and 21 were digested with MboI, ligated to a linker/adaptor, and then subjecte...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90378-6
更新日期:1992-02-01 00:00:00
abstract::We have previously reported that the expression of HC gp-39, a 39-kDa secretory glycoprotein and member of the chitinase protein family, is associated with late stages of monocyte to macrophage maturation. To allow further investigations of its unique expression pattern and to facilitate studies on the regulation of t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4778
更新日期:1997-07-15 00:00:00
abstract::The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1256
更新日期:1994-05-01 00:00:00
abstract::A gene for autosomal recessive juvenile parkinsonism (ARJP; HGMW-approved symbol PARK2; MIM 600116) has recently been mapped to a 17-cM interval on chromosome 6q25.2-q27. We here report an inbred family with ARJP showing a perfect cosegregation with null allele for D6S305, which is a marker within the ARJP locus. We a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.5196
更新日期:1998-04-01 00:00:00
abstract::We have isolated and examined the gene for the heart isoform of cytochrome c oxidase subunit VIIa (COX VIIa-H) in mouse, an isoform gene previously thought to be lacking in rodents. Interspecies amino acid comparisons indicate that mouse COX VIIa-H protein displays 82.5 and 70.9% identity with the bovine and human hea...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5279
更新日期:1998-05-01 00:00:00
abstract::A cosmid library has been constructed with DNA isolated from a mouse/human hybrid cell line designated A15, which was previously characterized and shown to retain chromosome 15 as the only human material. The library was generated and stored as 34 independent pools of primary colonies at 8-10,000 colonies per pool. Sc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4517
更新日期:1997-02-15 00:00:00
abstract::Pulsed-field gel electrophoresis and flow dot-blot analysis have been used to construct a physical map of the q32-q34 region of chromosome 9, where one of the loci responsible for tuberous sclerosis (TSC1) has been mapped by genetic linkage. Five linked groups of markers have been defined by pulsed-field gel electroph...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1056
更新日期:1993-02-01 00:00:00
abstract::To identify large proteins with an EGF-like-motif in a systematic manner, we developed a computer-assisted method called motif-trap screening. The method exploits 5'-end single-pass sequence data obtained from a pool of cDNAs whose sizes exceed 5 kb. Using this screening procedure, we were able to identify five known ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5341
更新日期:1998-07-01 00:00:00
abstract::The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined. Northern blot analysis across a range of human tissues revealed that both the TADA2L and the GCN5L2 mRNAs are expressed to varying degrees in all tissue types. Furthermore, in most...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4605
更新日期:1997-03-15 00:00:00
abstract::Long sequencing reads offer unprecedented opportunities in analysis and reconstruction of complex genomic regions. However, the gain in sequence length is often traded for quality. Therefore, recently several approaches have been proposed (e.g. higher sequencing coverage, hybrid assembly or sequence correction) to enh...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2017.12.011
更新日期:2019-01-01 00:00:00
abstract::Childhood-onset asthma is frequently found in association with atopy. Although asthmatic children may develop IgE antibodies against variety of allergens, asthma is associated primarily with allergy to house-dust mites, molds, or other allergens. In this study, we conducted a genome-wide linkage search in 47 Japanese ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6201
更新日期:2000-06-01 00:00:00
abstract::Afrotheria genome size is reported to be over 50% larger than that of human, but we show that this is a gross overestimate. Although genome sequencing in Afrotheria is not complete, extensive homology with human has been revealed by chromosome painting. We provide new data on chromosome size and GC content in four Afr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2013.09.002
更新日期:2013-11-01 00:00:00
abstract::Overlapping DNA fragments spanning approximately 21 kb of genomic DNA and encompassing the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) have been cloned by screening a human leukocyte genomic library and by PCR amplification of human fibroblastic DNA. A continuous gene sequence of 20,890 nucleotides was establ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4887
更新日期:1997-09-15 00:00:00
abstract::The objective of this study was to identify gene expression differences in blood differences in children with autism (AU) and autism spectrum disorder (ASD) compared to general population controls. Transcriptional profiles were compared with age- and gender-matched, typically developing children from the general popul...
journal_title:Genomics
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ygeno.2007.09.003
更新日期:2008-01-01 00:00:00
abstract::We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses. The human PTP epsilon gene (gene symbol PTPRE) was mapped to chromosome 10q26 by fluorescence in situ hybridization....
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0061
更新日期:1996-02-01 00:00:00
abstract::The acyl-CoA dehydrogenases (ACDs) are a family of mitochondrial enzymes that oxidize straight chain or branched chain acyl-CoAs in the metabolism of fatty acids or branched chain amino acids. Deficiencies in members of this gene family are important causes of human disease. A cDNA encoding the human precursor for a n...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1617
更新日期:1994-11-15 00:00:00
abstract::Glaucoma is a very common disorder of the eye wherein the disturbance of the structural or functional integrity of the optic nerve causes characteristic atrophic changes in the optic nerve, which may lead to specific visual field defects over time. Primary open angle glaucoma (POAG) is most frequent among the three pr...
journal_title:Genomics
pub_type: 杂志文章,评审
doi:10.1016/j.ygeno.2016.11.003
更新日期:2017-01-01 00:00:00
abstract::Histamine N-methyltransferase (HNMT), a cytosolic histamine-metabolizing enzyme, is the only known product of the 50-kb human HNMT. Here, a detailed investigation of HNMT products revealed the existence of a new brain mRNA product of HNMT. This species, named HNMT-Short (HNMT-S), encodes a 126-amino-acid protein. Nort...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00236-2
更新日期:2004-01-01 00:00:00
abstract::The human homeobox gene HLX1 appears to be involved in hemopoietic development and may represent a candidate gene for various developmental or hemopoietic disorders. We have isolated genomic clones for the gene, determined its intron-exon organization, and confirmed its map location on chromosome 1q41-q42. The transcr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1394
更新日期:1994-07-15 00:00:00
abstract::We have isolated and characterized a novel cDNA coding for a highly hydrophobic protein (B5) from a fetal mouse mandibular condyle cDNA library. The full-length mouse B5 cDNA is 3095 nucleotides long and contains a potential open reading frame coding for a protein of 705 amino acids with a calculated molecular weight ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0051
更新日期:1996-02-01 00:00:00
abstract::More than 500 backcross progeny from four intersubspecific backcrosses were typed for six markers on distal mouse chromosome 16. Five of these represented genes that mapped within the Sod-1 to Ets-2 interval, which was shown previously to contain the weaver (wv) gene. The map order, including previously mapped referen...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1336
更新日期:1993-08-01 00:00:00
abstract::Acidic epididymal glycoprotein (AEG), thus far identified only in rodents, is one of the sperm surface proteins involved in the fusion of the sperm and egg plasma membranes. In the present study, we describe the isolation and characterization of cDNA encoding a human glycoprotein related to AEG. Although this protein,...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0131
更新日期:1996-03-15 00:00:00
abstract::We isolated a mouse cDNA encoding APEX2 protein and demonstrated that APEX2 binds to PCNA. The level of Apex2 mRNA was high in the thymus, bone marrow, spleen, and kidney in adult mice. Apex2 consists of six exons and is flanked on the 3' end by Alas2 on X chromosome 63.0. Furthermore, Apex2 is flanked on the 5' end b...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(02)00009-5
更新日期:2003-01-01 00:00:00
abstract::Synucleins are a family of small intracellular proteins expressed mainly in the nervous system. The involvement of synucleins in neurodegeneration and malignancy has been demonstrated, but the physiological functions of these proteins remain elusive. Further studies including generation of animals with modified persyn...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5674
更新日期:1999-03-01 00:00:00