High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16.

Abstract:

:More than 500 backcross progeny from four intersubspecific backcrosses were typed for six markers on distal mouse chromosome 16. Five of these represented genes that mapped within the Sod-1 to Ets-2 interval, which was shown previously to contain the weaver (wv) gene. The map order, including previously mapped reference markers, is (cen)-D16H21S16-D16Led-1-App-Sod-1-Gart-Gas-4-Cbr++ +-wv-Pcp-4-Erg-Ets-2. This gene order recapitulates the order of the genes on human chromosome 21 where known. Two of these markers further define the region containing the weaver gene to a 3.9-cM segment between Cbr and Pcp-4. In addition, Pcp-4 was localized to human chromosome 21 by the presence of a human-specific restriction fragment in WAV-17, a mouse-human somatic cell hybrid with human chromosome 21 as the only human contribution.

journal_name

Genomics

journal_title

Genomics

authors

Mjaatvedt AE,Citron MP,Reeves RH

doi

10.1006/geno.1993.1336

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

382-6

issue

2

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(83)71336-4

journal_volume

17

pub_type

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