Abstract:
:We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses. The human PTP epsilon gene (gene symbol PTPRE) was mapped to chromosome 10q26 by fluorescence in situ hybridization. We have previously documented the existence of two isoforms of PTP epsilon--a transmembranal, receptor-type isoform and a shorter, cytoplasmic one. Both isoforms have been suggested to arise from a single gene through the use of alternative promoters and 5' exons. The identification of a single PTP epsilon locus in both organisms is consistent with this suggestion.
journal_name
Genomicsjournal_title
Genomicsauthors
Elson A,Kozak CA,Morton CC,Weremowicz S,Leder Pdoi
10.1006/geno.1996.0061subject
Has Abstractpub_date
1996-02-01 00:00:00pages
373-5issue
3eissn
0888-7543issn
1089-8646pii
S0888754396900610journal_volume
31pub_type
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