Abstract:
:The canine species, including wolf and jackal, have four digits on the hind limb. It was thought that an extra first digit on the hind limb, named dewclaw, was a hereditary defect. For genetically related canine pedigrees with 73 members with dewclaws, we carried out a genome-wide scan for linkage with microsatellites. With an assumption of autosomal dominant mode of inheritance, significant linkages were detected for the markers on canine chromosome 16. The maximum two-point lod score of 20.76 was obtained for the REN85M08/REN85N14 markers at a recombination fraction of 0.00. For efficient analysis of linkage, a revised order of the chromosomal markers was established by assigning all the existing markers from the previous linkage and radiation hybrid maps. A chromosome-wide haplotype analysis revealed the location of the dewclaw locus within a few centimorgan intervals delimited by the UCMCF12 and CXX876 markers. Canine chromosome 16 is known to have syntenic relationships with human chromosomes 4q, 7q, and 8p.
journal_name
Genomicsjournal_title
Genomicsauthors
Park K,Kang J,Park S,Ha J,Park Cdoi
10.1016/s0888-7543(03)00234-9subject
Has Abstractpub_date
2004-02-01 00:00:00pages
216-24issue
2eissn
0888-7543issn
1089-8646pii
S0888754303002349journal_volume
83pub_type
杂志文章相关文献
GENOMICS文献大全abstract::The chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed to provide a resource for long-range mapping of this region. A large fraction of the hybrids (approximately 90%) retained...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1383
更新日期:1993-09-01 00:00:00
abstract::A large insert canine genomic bacterial artificial chromosome (BAC) library was built from a Doberman pinscher. Approximately 166,000 clones were gridded on nine high-density hybridization filters. Insert analysis of randomly selected clones indicated a mean insert size of 155 kb and predicted 8.1 coverage of the cani...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.5772
更新日期:1999-05-15 00:00:00
abstract::Cloning and characterization of the cystic fibrosis transmembrane conductance regulator (CFTR) gene led to the identification and isolation of cDNA and genomic sequences that cross-hybridized to the first nucleotide binding fold of CFTR. DNA sequence analysis of these clones showed that the cross-hybridizing sequences...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4968
更新日期:1997-11-01 00:00:00
abstract::Molecular loss of heterozygosity studies on human gliomas have shown several regions on chromosome 10 frequently deleted in higher grade tumors, suggesting that chromosome 10 may contain several tumor suppressor genes. We assessed loss of heterozygosity with microsatellite markers in 20 gliomas, consisting of various ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0277
更新日期:1996-06-01 00:00:00
abstract::The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of various histological types but not in normal tissues except testis. The MAGE genes are arranged in two groups that are...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1108
更新日期:1995-07-01 00:00:00
abstract::Multiple infections by HPV genotypes are frequently detected in HPV+ cervical lesions but the interaction between each viral genotype during carcinogenesis is poorly understood. Here we carried out a comprehensive study to characterize the multiple HPV expression and integration by RNA-seq analyses of 19 invasive cerv...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.05.009
更新日期:2020-09-01 00:00:00
abstract::Deficiency of the lysosomal enzyme, N-acetylgalactosamine 6-sulfatase (GALNS;EC 3.1.6.4), results in the storage of the glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate, which leads to the lysosomal storage disorder Morquio A syndrome. Four overlapping genomic clones derived from a chromosome 16-specific ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1443
更新日期:1994-08-01 00:00:00
abstract::SCG10 is a neuronal growth-associated protein that shares an amino acid sequence similarity with an 18- to 19-kDa phosphoprotein named stathmin (also called p19, p18, Op18, pp17, prosolin, pp20, 19K, and leukemia-associated phosphoprotein, Lap18), which is more broadly expressed in a variety of cell types of the neura...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1477
更新日期:1993-11-01 00:00:00
abstract::Aminoacylase-1 (ACY1, EC 3.5.1.14) is a cytosolic enzyme with a wide range of tissue expression and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21, a region reduced to homozygosity in small-cell lung cancer and renal cell carcinoma, and ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90237-o
更新日期:1990-09-01 00:00:00
abstract::We used targeted exon trapping to clone portions of genes from human chromosome 21q22.3. One trapped sequence showed complete homology with the cDNA of human U2AF35 (M96982; HGM-approved nomenclature U2AF1), which encodes for the small 35-kDa subunit of the U2 snRNP auxiliary factor. Using the U2AF1 cDNA as a probe, w...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0196
更新日期:1996-04-15 00:00:00
abstract::Regions of the genome showing high evolutionary stability are often conserved as a result of functional constraints. Conversely, more variable regions are likely to represent DNA with no functional or structural importance. However, as in the case of immunologically important regions, sequence divergence does not alwa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90170-j
更新日期:1991-10-01 00:00:00
abstract::Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. Polymorphisms in both APOA5 and APOC3 are strongly associated with plasma triglyceride concentrations. The close genomic locations of these two genes as well as their functional similarity ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2003.11.016
更新日期:2004-05-01 00:00:00
abstract::The use of round spermatids that are fully active at the transcriptional level to create zygotes (i.e. round spermatid injection; ROSI) raises the question regarding the downregulation of all specific genes that are transcribed from the paternal genome at fertilization. In this study, we show that protamine 1 and 2 mR...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.12.004
更新日期:2008-05-01 00:00:00
abstract::Of 311 expressed sequenced tags (ESTs) mapped to single human chromosomes by analysis of a monochromosome somatic cell hybrid panel, 29 were localized to chromosome 3. Analysis of somatic cell hybrid lines containing different regions of chromosome 3 has enabled the regional assignment of these 29 ESTs to 13 of 23 int...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5484
更新日期:1998-11-01 00:00:00
abstract::A human mitochondrial DNA (mtDNA) standard reference material (SRM 2392) will provide quality control when mtDNA is sequenced for forensic identifications, medical diagnosis, or mutation detection. SRM 2392 includes DNA from two lymphoblast cell cultures (CHR and 9947A) and cloned DNA from the CHR HV1 region, which co...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5513
更新日期:1999-01-15 00:00:00
abstract::The human CBFA2T1 (also known as MTG8) gene, on chromosome 8, has been identified through its involvement in the t(8;21) chromosomal translocation, frequently found in acute myeloid leukemia. We report here the isolation and characterization of the mouse homologue of the CBFA2T1 gene, Cbfa2t1h. Nucleotide sequence ana...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.9941
更新日期:1995-10-10 00:00:00
abstract::Using antibodies directed against the amino-terminus of dystrophin, we identified a truncated protein in a Duchenne muscular dystrophy patient. Antibodies directed against the carboxy-terminus failed to identify any cross-reactive material, a result consistent with premature termination of dystrophin translation. The ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90332-9
更新日期:1991-06-01 00:00:00
abstract::Uroporphyrinogen-III (URO) synthase is the heme biosynthetic enzyme defective in congenital erythropoietic porphyria. The approximately 34-kb human URO-synthase gene (UROS) was isolated, and its organization and tissue-specific expression were determined. The gene had two promoters that generated housekeeping and eryt...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6373
更新日期:2000-12-01 00:00:00
abstract::In our previous studies, diploid and triploid hybrids have been detected from the hybridization of Epinephelus coioides♀ × E. lanceolatus♂. The triploid groupers have been found to be delayed in gonadal development, but the mechanism remains poorly understood. In this study, we examined the gonadal development, assaye...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.11.010
更新日期:2019-05-01 00:00:00
abstract::Comparative genetic analysis between human and chimpanzee may detect genetic divergences responsible for human-specific characteristics. Previous studies have identified a series of genes that potentially underwent Darwinian positive selection during human evolution. However, without a closely related species as outgr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.05.008
更新日期:2006-12-01 00:00:00
abstract::We describe here a 1.2-Mb yeast artificial chromosome (YAC) contig within the region of mouse chromosome 17 between Brachyury (T) and D17Rp17e, and spanning the quaking (qk) region. We describe six new probes distributed across 1.2 Mb: D17Leh502, D17Leh503, D17Leh504, D17Leh505, D17Leh506, and D17Leh507. Probes D17Leh...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1227
更新日期:1994-05-01 00:00:00
abstract::The human genome contains a group of gene families whose members map within the same regions of chromosomes 1, 6, and 9. The number of gene families involved and their pronounced clustering to the same areas of the genome indicate that their mapping relationship is nonrandom. By combining mapping data and sequence inf...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0328
更新日期:1996-07-01 00:00:00
abstract::We have constructed a high-resolution map of a 6-Mb interval of human chromosome 5, band q31, incorporating 175 sequence tagged sites, of which 33 are genetic polymorphisms and 122 are nonredundant expressed sequences. The map was assembled initially as a YAC contig, incorporating data from radiation hybrid maps. To i...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.5765
更新日期:1999-04-01 00:00:00
abstract::We show a mute 9.1-kb gap in the human genome reference map, unraveled by RDA studies, to be a worldwide deletion/insertion polymorphism of stable type. The molecular and population data presented suggest its origin from a unique ancestral transposition event in chromosomal region 22q11.2, overlapping the IglambdaV ge...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.7014
更新日期:2002-12-01 00:00:00
abstract::The retina and its adjacent supporting tissues - retinal pigmented epithelium (RPE) and choroid - are critical structures in human eyes required for normal visual perception. Abnormal changes in these layers have been implicated in diseases such as age-related macular degeneration and glaucoma. With the advent of high...
journal_title:Genomics
pub_type: 杂志文章,评审
doi:10.1016/j.ygeno.2015.01.008
更新日期:2015-05-01 00:00:00
abstract::The RBM (RNA-binding motif) gene family on the human Y chromosome encodes proteins with an RNA-binding domain. Its exclusive expression in germ cells and its partial deletion in some azoospermic or severely oligospermic males provide evidence of a role for RBM genes in spermatogenesis. There are approximately 30 RBM g...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4944
更新日期:1997-10-15 00:00:00
abstract::Core binding factor (CBF) is a heterodimeric transcription factor composed of two distinct subunits. The monomeric beta subunit is ubiquitously expressed, whereas expression of the three alpha subunits isolated previously seems to be restricted mainly to hematopoietic tissues. To isolate additional alpha genes, degene...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80185-o
更新日期:1995-04-10 00:00:00
abstract::Nearly 60 unique J alpha regions have been identified in human T-cell receptor (TCR) alpha chains to date, yet fewer than one-third of these have been localized within the alpha-chain locus. We report a rapid method for the mapping of productively rearranged J alpha regions using oligonucleotide probes and overlapping...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1172
更新日期:1993-04-01 00:00:00
abstract::Chemotherapeutic response of cancer cells to a given compound is one of the most fundamental information one requires to design anti-cancer drugs. Recently, considerable amount of drug-induced gene expression data has become publicly available, in addition to cytotoxicity databases. These large sets of data provided a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.07.002
更新日期:2019-09-01 00:00:00
abstract::Treatment for lower-grade gliomas (LGG) has been challenging. Though emerging approaches such as immunotherapy is promising, it is still faced with immune tolerance, an obstacle that may be overcome by targeting autophagy-related (ATG) genes. After identifying three differentially expressed ATG genes (RIPK2, MUL1 and ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.008
更新日期:2020-10-15 00:00:00