Abstract:
:Nearly 60 unique J alpha regions have been identified in human T-cell receptor (TCR) alpha chains to date, yet fewer than one-third of these have been localized within the alpha-chain locus. We report a rapid method for the mapping of productively rearranged J alpha regions using oligonucleotide probes and overlapping phage clones spanning 80 kb of the TCR-alpha locus. Fourteen J alpha regions were mapped using this technique; the positions of five of these have been verified by genomic cloning.
journal_name
Genomicsjournal_title
Genomicsauthors
Harvey RC,Showe LCdoi
10.1006/geno.1993.1172subject
Has Abstractpub_date
1993-04-01 00:00:00pages
262-3issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(83)71172-9journal_volume
16pub_type
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