Abstract:
:Comparative genetic analysis between human and chimpanzee may detect genetic divergences responsible for human-specific characteristics. Previous studies have identified a series of genes that potentially underwent Darwinian positive selection during human evolution. However, without a closely related species as outgroup, it is difficult to identify human-lineage-specific changes, which is critical in delineating the biological uniqueness of humans. In this study, we conducted phylogeny-based analyses of 2633 human brain-expressed genes using rhesus macaque as the outgroup. We identified 47 candidate genes showing strong evidence of positive selection in the human lineage. Genes with maximal expression in the brain showed a higher evolutionary rate in human than in chimpanzee. We observed that many immune-defense-related genes were under strong positive selection, and this trend was more prominent in chimpanzee than in human. We also demonstrated that rhesus macaque performed much better than mouse as an outgroup in identifying lineage-specific selection in humans.
journal_name
Genomicsjournal_title
Genomicsauthors
Yu XJ,Zheng HK,Wang J,Wang W,Su Bdoi
10.1016/j.ygeno.2006.05.008subject
Has Abstractpub_date
2006-12-01 00:00:00pages
745-751issue
6eissn
0888-7543issn
1089-8646pii
S0888-7543(06)00166-2journal_volume
88pub_type
杂志文章相关文献
GENOMICS文献大全abstract::Neuroendocrine-Dlg (NE-Dlg) is a member of the discs-large-related (DLG) subfamily of the membrane-associated guanylate kinase-related protein family. Based on evidence from model systems, this protein appears to be critical for synaptogenesis, acting as a site-specific organizational center for integral membrane prot...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5243
更新日期:1998-04-15 00:00:00
abstract::Macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine. However, recent work strongly suggests a wider role for MIF beyond the immune system. It is expressed specifically in the differentiating cells of the immunologically privileged eye lens and brain, is a delayed early response gene ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1011
更新日期:1994-01-01 00:00:00
abstract::Childhood-onset asthma is frequently found in association with atopy. Although asthmatic children may develop IgE antibodies against variety of allergens, asthma is associated primarily with allergy to house-dust mites, molds, or other allergens. In this study, we conducted a genome-wide linkage search in 47 Japanese ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6201
更新日期:2000-06-01 00:00:00
abstract::We investigated a family with a duplication, dup(X)q26-q27, that was present in two brothers, their mother, and their maternal grandmother. The brothers carrying the duplication displayed spina bifida and panhypopituitarism, whereas a third healthy brother inherited the normal X chromosome. Preferential inactivation o...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6327
更新日期:2000-10-15 00:00:00
abstract:UNLABELLED:Pancreatic cancer is one of the most aggressive malignant tumors, mainly due to an aggressive metastasis spreading. In recent years, circulating tumor cells became associated to tumor metastasis. Little is known about their expression profiles. The aim of this study was to develop a complete workflow making ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2015.02.003
更新日期:2015-07-01 00:00:00
abstract::PCR primers specific to the human liver fructose-1,6-bisphosphatase (FBP) gene were designed and used to isolate a cosmid clone. Physical mapping of the FBP cosmid by FISH, and genetic mapping of an associated GA repeat polymorphism (PIC = 0.35), located the liver FBP gene to chromosome 9q22.3 with no recombination be...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1230
更新日期:1995-09-01 00:00:00
abstract::Thirty-five new, unique, DNA probes have been isolated and each has been assigned to one of five regions on chromosome 22. The distribution of probes along the chromosome is what would be expected based on the estimated size of each region with the exception of the short arm (22p). RFLP analysis was performed using 13...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90190-p
更新日期:1991-08-01 00:00:00
abstract::We have developed a high-information-content fingerprinting (HICF) system for bacterial artificial chromosome (BAC) clones using a Type IIS restriction endonuclease, HgaI, paired with a Type II restriction endonuclease, RsaI. In the method described, unknown five-base overhangs generated with HgaI are partially or ful...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2001.6547
更新日期:2001-06-01 00:00:00
abstract::Hermansky-Pudlak syndrome (HPS) is a group of human disorders of organelle biogenesis characterized by defective synthesis of melanosomes, lysosomes, and platelet dense granules. In the mouse, at least 15 loci are associated with mutant phenotypes similar to human HPS. We have identified the gene mutated in cocoa (coa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2001.6644
更新日期:2001-11-01 00:00:00
abstract::Heme oxygenase catalyzes the oxidation of heme to biliverdin, the precursor of the bile pigment bilirubin, and carbon monoxide, a putative neurotransmitter. We have employed polymerase chain reaction and fluorescence in situ hybridization to determine the chromosome localization of the genes coding for the two known h...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1213
更新日期:1994-04-01 00:00:00
abstract::The human CBFA2T1 (also known as MTG8) gene, on chromosome 8, has been identified through its involvement in the t(8;21) chromosomal translocation, frequently found in acute myeloid leukemia. We report here the isolation and characterization of the mouse homologue of the CBFA2T1 gene, Cbfa2t1h. Nucleotide sequence ana...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.9941
更新日期:1995-10-10 00:00:00
abstract::Mitochondrial intermediate peptidase (MIP) is a component of the mitochondrial protein import machinery required for maturation of nuclear-encoded precursor proteins targeted to the mitochondrial matrix or inner membrane. We previously characterized this enzyme in rat (RMIP) and Saccharomyces cerevisiae (YMIP) and sho...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1174
更新日期:1995-08-10 00:00:00
abstract::We have isolated cDNA and genomic clones coding for the human alpha 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha 7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1075
更新日期:1994-01-15 00:00:00
abstract::We have isolated a human cDNA encoding a protein of 334 amino acids that shows 96% identity in amino acid sequence to murine cytosolic malate dehydrogenase. Heart and skeletal muscle expressed this gene most highly among the adult human tissues examined by Northern blot analysis. By fluorescence in situ hybridization,...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0087
更新日期:1996-02-15 00:00:00
abstract::The proximal albino deletions identify several functional regions on mouse Chromosome 7 critical for differentiation of mesoderm (mesd), development of the hypothalamus neuroendocrine lineage (nelg), and function of the liver (hsdr1). Using comparative mapping and genomic sequence analysis, we have identified four nov...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6466
更新日期:2001-02-15 00:00:00
abstract::The large number of redundant sequences available in nucleotide databases provides a resource for the identification of polymorphisms. Expressed polymorphisms in X-linked genes can be used to determine the inactivation status of the genes, and polymorphisms in genes that are subject to inactivation can then be used as...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6153
更新日期:2000-04-01 00:00:00
abstract::The genomic structure of the mouse gene encoding the CDEBP protein has been established. The protein was initially identified on the basis of its ability to bind the CDEI motif (GTCACATG). The same locus has been independently described under the name APLP2, on the basis of sequence similarities with the Amyloid Precu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0318
更新日期:1996-07-01 00:00:00
abstract::We report for the first time the fragmented mitochondrial (mt) genomes of two Pedicinus species: Pedicinus obtusus and Pedicinus badii, and compared them with the lice of humans and chimpanzees. Despite being congeneric, the two monkey lice are distinct from each other in mt karyotype. The variation in mt karyotype be...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.09.005
更新日期:2020-11-01 00:00:00
abstract::Treacher Collins syndrome is an autosomal dominant condition of bilateral craniofacial abnormalities of structures derived from the first and second branchial arches. A patient with severe manifestations of Treacher Collins syndrome and a de novo chromosomal deletion in region 4p15.32----p14 was identified. Anonymous ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90117-w
更新日期:1991-09-01 00:00:00
abstract::This study has investigated the transcriptional regulation of the Emr1 gene in murine macrophages and defined an enhancer element within the proximal promoter that is necessary for Emr1 expression in myeloid cells. This element consists of an extended purine-rich sequence (PuRS) of 83 consecutive purine residues conta...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.08.016
更新日期:2004-12-01 00:00:00
abstract::Linkage of the gene responsible for an X-linked early onset parkinsonism disorder with mental retardation (McKusick 311510) to DNA probes that detect restriction fragment length polymorphisms is described. The disease gene is linked to the F8C gene, and to DNA probes detecting polymorphic loci DXS52, DXS15, DXS134, an...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90363-j
更新日期:1991-04-01 00:00:00
abstract::Thirteen moderately to highly informative microsatellite DNA polymorphisms based on (dC-dA)n.(dG-dT)n repeats were mapped to segments of human chromosome 5 using both linkage analysis and a panel of somatic cell hybrids which contained rearranged chromosomes. The markers were distributed throughout most of the length ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90077-r
更新日期:1991-11-01 00:00:00
abstract::The gene responsible for the second form of autosomal dominant polycystic kidney disease, PKD2, has recently been identified. We now describe the cloning, genomic localization, cDNA sequence, and expression analysis of its murine homologue, Pkd2. The cloned cDNA sequence is 5134 bp long and is predicted to encode a 96...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4920
更新日期:1997-10-01 00:00:00
abstract::Isozyme and restriction fragment length polymorphism (RFLP) analyses of backcross progeny, recombinant inbred strains, and congenic strains of mice positioned eight genetic markers with respect to the Lsh-Ity-Bcg disease resistance locus. Allelic isoforms of Idh-1 and Pep-3 and RFLPs detected by Southern hybridization...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90518-y
更新日期:1990-05-01 00:00:00
abstract::DNA 5' to the human myelin basic protein (MBP) gene, mapped to 18q22----qter, is known to manifest multiallelic DNA length variation with heterozygosity of at least 45%. Isolation of genomic DNA containing the MBP gene first exon and its 5' flanking region reveals that this polymorphism arises from a 994-bp region of ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90443-x
更新日期:1990-01-01 00:00:00
abstract::We developed a computational model to explore the hypothesis that regulatory instructions are context dependent and conveyed through specific 'codes' in human genomic DNA. We provide examples of correlation of computational predictions to reported mapped DNase I hypersensitive segments in the HOXA locus in human chrom...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2008.11.008
更新日期:2009-04-01 00:00:00
abstract::The cerebral cortex is a tissue with a high degree of neuronal diversity. It consists of six cell layers with a unique set of neuronal subtypes. A crucial step in the process of cortical differentiation is the transition from a mitotically active neuroblast to a postmitotic young neuron. To identify genes involved in ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.6796
更新日期:2002-07-01 00:00:00
abstract::The complexity of the somatic embryogenesis (SE) transcriptome suggests that numerous molecules are involved. To understand better the functional genomics of complex molecular systems during this important reprogramming process, we used bioinformatics and a pathway database to construct a draft network based on transc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.07.007
更新日期:2007-11-01 00:00:00
abstract::Understanding patterns of linkage disequilibrium (LD) across genomes may facilitate association mapping studies to localize genetic variants influencing complex diseases, a recognition that led to the International Haplotype Mapping Project (HapMap). Divergent patterns of haplotype frequency and LD across global popul...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.03.003
更新日期:2006-11-01 00:00:00
abstract::The ST2 gene is a member of the IL-1 receptor family and is hypothesized to be involved in helper T cell function, but its functional ligand and physiological role remain unknown. We have cloned the human ST2L cDNA that encodes a distinct type of membrane-bound ST2 protein. The predicted 556-amino-acid sequence showed...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6269
更新日期:2000-08-01 00:00:00