Abstract:
:The retina and its adjacent supporting tissues - retinal pigmented epithelium (RPE) and choroid - are critical structures in human eyes required for normal visual perception. Abnormal changes in these layers have been implicated in diseases such as age-related macular degeneration and glaucoma. With the advent of high-throughput methods, such as serial analysis of gene expression, cDNA microarray, and RNA sequencing, there is unprecedented opportunity to facilitate our understanding of the normal retina, RPE, and choroid. This information can be used to identify dysfunction in age-related macular degeneration and glaucoma. In this review, we describe the current status in our understanding of these transcriptomes through the use of high-throughput techniques.
journal_name
Genomicsjournal_title
Genomicsauthors
Tian L,Kazmierkiewicz KL,Bowman AS,Li M,Curcio CA,Stambolian DEdoi
10.1016/j.ygeno.2015.01.008subject
Has Abstractpub_date
2015-05-01 00:00:00pages
253-64issue
5-6eissn
0888-7543issn
1089-8646pii
S0888-7543(15)00025-7journal_volume
105pub_type
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