Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9.


:Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for LFA-1, a beta 2 leukocyte integrin. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses. We have mapped this gene to proximal mouse chromosome 9 by using mouse-hamster somatic cell hybrids and an interspecies backcross. Since human ICAM-1 maps to chromosome 19, it joins the LDL receptor to establish a new conserved syntenic segment between human chromosome 19 and proximal mouse chromosome 9. Murine Icam-1 maps between Cbl-2 and the centromere in the same region as one of the susceptibility genes for insulin-dependent diabetes mellitus (Idd-2) that is postulated to play a role in immune function and inflammation leading to insulitis. The mapping of Icam-1 to the region known to contain the Idd-2 gene raises the question of whether the phenotypic differences attributed to the Idd-2 locus might be due to genetic variation in Icam-1.






Ballantyne CM,Kozak CA,O'Brien WE,Beaudet AL




Has Abstract


1991-03-01 00:00:00
















  • Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and the 5' region of PEX.

    abstract::Human Xp22.1 contains genes involved in mineral balance that are implicated in X-linked hypophosphatemia (XLH) in humans, its murine homologue (Hyp), and another distinct murine hypophosphatemic disorder (Gy). In XLH, a gene, PEX, has been found to be mutated in up to 83% of patients but the sequences of the promoter ...


    pub_type: 杂志文章


    authors: Grieff M,Whyte MP,Thakker RV,Mazzarella R

    更新日期:1997-09-01 00:00:00

  • Chromosomal localization of the human homeo box-containing genes, EN1 and EN2.

    abstract::The human homologs of the mouse homeo box-containing genes, En-1 and En-2, which show homology to the Drosophila engrailed gene, have been isolated. The human EN1 gene was mapped to chromosome 2 by analysis of mouse-human somatic cell hybrids. The human EN2 gene was localized to chromosome 7, 7q32-7qter, by analysis o...


    pub_type: 杂志文章


    authors: Logan C,Willard HF,Rommens JM,Joyner AL

    更新日期:1989-02-01 00:00:00

  • Peripheral rods: a specialized developmental cell type in Myxococcus xanthus.

    abstract::In response to nutrient deprivation, the ubiquitous Gram-negative soil bacterium Myxococcus xanthus undergoes a well-characterized developmental response, resulting in the formation of a multicellular fruiting body. The center of the fruiting body consists of myxospores; surrounding this structure are rod-shaped perip...


    pub_type: 杂志文章


    authors: Whitfield DL,Sharma G,Smaldone GT,Singer M

    更新日期:2020-03-01 00:00:00

  • Fine-mapping of the spinal muscular atrophy locus to a region flanked by MAP1B and D5S6.

    abstract::The microtubule-associated protein 1B (MAP1B) locus has been mapped in close proximity to spinal muscular atrophy (SMA) on chromosome 5q13. We have identified a second microsatellite within a MAP1B intron, which increases the heterozygosity of this locus to 94%. Two unambiguous recombination events establish MAP1B as ...


    pub_type: 杂志文章


    authors: Brzustowicz LM,Kleyn PW,Boyce FM,Lien LL,Monaco AP,Penchaszadeh GK,Das K,Wang CH,Munsat TL,Ott J

    更新日期:1992-08-01 00:00:00

  • The gene for the alpha-subunit of retinal rod transducin is on mouse chromosome 9.

    abstract::Mice carrying the autosomal recessive rd gene experience total degeneration of the photoreceptor cells of the retina by 3 to 4 weeks of life. Biochemical studies of the rd retina have demonstrated a lesion in cyclic guanosine monophosphate (cGMP) metabolism due to depressed rod-specific cGMP-phosphodiesterase (cGMP-PD...


    pub_type: 杂志文章


    authors: Danciger M,Kozak CA,Farber DB

    更新日期:1989-02-01 00:00:00

  • Identification of CpG islands in a physical map encompassing the Friedreich's ataxia locus.

    abstract::The Friedreich's ataxia locus has been previously assigned to chromosome 9q 13-21.1 by the demonstration of tight linkage to two anonymous DNA markers. MCT112 (Z greater than 80, theta = 0) and DR47 (Z greater than 50, theta = 0). The absence of recombination between these three loci has prevented the resolution of ge...


    pub_type: 杂志文章


    authors: Wilkes D,Shaw J,Anand R,Riley J,Winter P,Wallis J,Driesel AG,Williamson R,Chamberlain S

    更新日期:1991-01-01 00:00:00

  • iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC.

    abstract::N6-methyladenine (6mA) is one kind of post-replication modification (PTM or PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will be very helpful for revealing the biological functions of 6mA, but it is time-consuming and expensive to determine them by experiments alone. Unfortuna...


    pub_type: 杂志文章


    authors: Feng P,Yang H,Ding H,Lin H,Chen W,Chou KC

    更新日期:2019-01-01 00:00:00

  • Revealing new landscape of cardiovascular disease through circular RNA-miRNA-mRNA axis.

    abstract::Non-coding RNA (ncRNA) is a kind of RNA, produced by genomic transcription and does not encode protein, but can regulate the function of genes, thus widely regulating pathological and physiological processes. The dynamic balance of the reticular structure between them is needed to regulate the homeostasis, the abnorma...


    pub_type: 杂志文章,评审


    authors: Su Q,Lv X

    更新日期:2020-03-01 00:00:00

  • Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23.

    abstract::A genetic basis for neural tube defects (NTD) is rarely doubted, but the genes involved have not yet been identified. This is partly due to a lack of suitable families on which to perform linkage analysis. An alternative approach is to use the many mouse genes that cause NTD as a means of isolating their human homolog...


    pub_type: 杂志文章


    authors: Stanier P,Henson JN,Eddleston J,Moore GE,Copp AJ

    更新日期:1995-04-10 00:00:00

  • Haplotypes in cystic fibrosis patients with or without pancreatic insufficiency from four European populations.

    abstract::We examined the allele and haplotype frequencies of five polymorphic DNA markers in 355 European cystic fibrosis (CF) patients (from Belgium, the German Democratic Republic, Greece, and Italy) who were divided into two groups according to whether they were or not taking supplementary pancreatic enzymes. The level of l...


    pub_type: 杂志文章


    authors: Devoto M,De Benedetti L,Seia M,Piceni Sereni L,Ferrari M,Bonduelle ML,Malfroot A,Lissens W,Balassopoulou A,Adam G

    更新日期:1989-11-01 00:00:00

  • The mouse transition protein 1 gene contains a B1 repetitive element and is located on chromosome 1.

    abstract::The gene for mouse transition protein 1 (mTP1) was isolated, sequenced, and chromosomally mapped. The nucleotide sequence of 1895 bp of a 6.4-kb mTP1 genomic subclone was determined to include 788 bp of 5' flanking region, 564 bp of coding region including a 396-bp intron and a TAA stop codon, and 543 bp of 3' flankin...


    pub_type: 杂志文章


    authors: Yelick PC,Kozak C,Kwon YK,Seldin MF,Hecht NB

    更新日期:1991-11-01 00:00:00

  • Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle.

    abstract::Syndactyly in Holstein cattle is an autosomal recessive abnormality characterized by the fusion of the functional digits. This disorder has been previously mapped to the telomeric part of bovine chromosome 15. Here, we describe the fine-mapping of syndactyly in Holstein cattle to a 3.5-Mb critical interval using a com...


    pub_type: 杂志文章


    authors: Duchesne A,Gautier M,Chadi S,Grohs C,Floriot S,Gallard Y,Caste G,Ducos A,Eggen A

    更新日期:2006-11-01 00:00:00

  • Rapid isolation of DNA probes within specific chromosome regions by interspersed repetitive sequence polymerase chain reaction.

    abstract::A method was recently developed for the specific amplification of human DNA sequences from interspecific somatic cell hybrids by the polymerase chain reaction (PCR) using primers directed to Alu, a short interspersed repeat element (SINE). We now show human-specific amplification using a primer to the 3' end of the hu...


    pub_type: 杂志文章


    authors: Ledbetter SA,Nelson DL,Warren ST,Ledbetter DH

    更新日期:1990-03-01 00:00:00

  • Genome-wide analysis of hepatic gene silencing in mammalian cell hybrids.

    abstract::Silencing of tissue-specific gene expression in mammalian somatic cell hybrids is a well-documented epigenetic phenomenon which is both profound (involving a large number of genes) and enigmatic. Our aim was to utilize whole-genome microarray analyses to determine the true extent of gene silencing on a genomic level. ...


    pub_type: 杂志文章


    authors: Bulla GA,Luong Q,Shrestha S,Reeb S,Hickman S

    更新日期:2010-12-01 00:00:00

  • Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians.

    abstract::The rate-limiting enzyme in insulin-mediated nonoxidative glucose disposal, glycogen synthase, has reduced activity in insulin-resistant subjects at risk for developing non-insulin-dependent diabetes mellitus (NIDDM). The synthase-activating enzyme, type 1 protein phosphatase (PP1), also has an abnormally low level of...


    pub_type: 杂志文章


    authors: Permana PA,Mott DM

    更新日期:1997-04-01 00:00:00

  • Identification and characterization of a cDNA and the structural gene encoding the mouse epithelial membrane protein-1.

    abstract::The PMP22/EMP/MP20 gene family includes four closely related proteins, peripheral myelin protein-22 (PMP22), epithelial membrane protein-1 (EMP-1), epithelial membrane protein-2 (EMP-2), and epithelial membrane protein-3 (EMP-3), which share amino acid identities ranging from 33 to 43%. In addition, the lens-specific ...


    pub_type: 杂志文章


    authors: Lobsiger CS,Magyar JP,Taylor V,Wulf P,Welcher AA,Program AE,Suter U

    更新日期:1996-09-15 00:00:00

  • Mapping of equine cerebellar abiotrophy to ECA2 and identification of a potential causative mutation affecting expression of MUTYH.

    abstract::Equine Cerebellar Abiotrophy (CA) is a neurological disease found in Arabian horses. CA is characterized by post-natal degeneration of the Purkinje cells of the cerebellum. Signs of CA include ataxia, head tremors, and a lack of balance equilibrium. We have discovered a linkage of the CA phenotype to a microsatellite ...


    pub_type: 杂志文章


    authors: Brault LS,Cooper CA,Famula TR,Murray JD,Penedo MC

    更新日期:2011-02-01 00:00:00

  • Whole genome single-nucleotide variation profile-based phylogenetic tree building methods for analysis of viral, bacterial and human genomes.

    abstract:UNLABELLED:Next-generation sequencing data can be mapped to a reference genome to identify single-nucleotide polymorphisms/variations (SNPs/SNVs; called SNPs hereafter). In theory, SNPs can be compared across several samples and the differences can be used to create phylogenetic trees depicting relatedness among the sa...


    pub_type: 杂志文章


    authors: Faison WJ,Rostovtsev A,Castro-Nallar E,Crandall KA,Chumakov K,Simonyan V,Mazumder R

    更新日期:2014-07-01 00:00:00

  • Amplification of CFTR exon 9 sequences to multiple locations in the human genome.

    abstract::Cloning and characterization of the cystic fibrosis transmembrane conductance regulator (CFTR) gene led to the identification and isolation of cDNA and genomic sequences that cross-hybridized to the first nucleotide binding fold of CFTR. DNA sequence analysis of these clones showed that the cross-hybridizing sequences...


    pub_type: 杂志文章


    authors: Rozmahel R,Heng HH,Duncan AM,Shi XM,Rommens JM,Tsui LC

    更新日期:1997-11-01 00:00:00

  • Isolation and regional mapping of NotI and EagI clones from human chromosome 21.

    abstract::NotI and EagI boundary libraries were constructed for human chromosome 21. One hundred forty-seven clones were isolated from the somatic cell hybrid 72532X-6 and localized using a hybrid mapping panel. After identification of those clones, which were isolated more than once, as well as those probes derived from a prev...


    pub_type: 杂志文章


    authors: Gao JZ,Erickson P,Patterson D,Jones C,Drabkin H

    更新日期:1991-05-01 00:00:00

  • Acquisition of social behavior in mammalian lineages is related with duplication events of FPR genes.

    abstract::Formyl peptide receptors (FPRs) were firstly detected in immune cells where they act as key mediators of leukocyte chemotaxis, promoting the host defense against pathogens. Recently, three paralogs were reported in Homo sapiens (FPR1-3) and seven paralogs in Mus musculus (FPR1, FPRrs1-4, FPRrs6 and FPRrs7), but inform...


    pub_type: 杂志文章


    authors: Silva L,Mendes T,Antunes A

    更新日期:2020-07-01 00:00:00

  • Point mutation in the human dystrophin gene: identification through western blot analysis.

    abstract::Using antibodies directed against the amino-terminus of dystrophin, we identified a truncated protein in a Duchenne muscular dystrophy patient. Antibodies directed against the carboxy-terminus failed to identify any cross-reactive material, a result consistent with premature termination of dystrophin translation. The ...


    pub_type: 杂志文章


    authors: Bulman DE,Gangopadhyay SB,Bebchuck KG,Worton RG,Ray PN

    更新日期:1991-06-01 00:00:00

  • The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21.

    abstract::Deletion of the long arm of chromosome 6 (6q) is one of the most common chromosomal abnormalities in human hematological malignancies. Two distinct regions of minimal deletion have been identified by loss of heterozygosity studies at 6q25 to 6q27 (RMD-1) and at 6q21 to 6q23 (RMD-2), suggesting the presence of one or m...


    pub_type: 杂志文章


    authors: Jackson A,Panayiotidis P,Foroni L

    更新日期:1998-05-15 00:00:00

  • Partial gene structure and assignment to chromosome 2q37 of the human inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13).

    abstract::The novel weakly inward rectifying potassium channel Kir7.1 is a low-conductance channel that is predominantly expressed in epithelial cells. Here we describe a partial genomic characterization and the chromosomal assignment of the human Kir7.1 gene (KCNJ13). Analysis of the genomic structure using a PCR-based approac...


    pub_type: 杂志文章


    authors: Derst C,Döring F,Preisig-Müller R,Daut J,Karschin A,Jeck N,Weber S,Engel H,Grzeschik KH

    更新日期:1998-12-15 00:00:00

  • Localization of three novel hybrid breakpoints and refinement of 18 marker assignments in the human 3cen-p21.1 region.

    abstract::Using the human/hamster cell line UCTP2A-3, we have generated and isolated three hybrids, each containing a novel human chromosome 3p break. All chromosome 3 materials distal to the breaks were lost. Two of the breakpoints were produced using aphidicolin induction; the third breakpoint occurred spontaneously. The aphi...


    pub_type: 杂志文章


    authors: Wang ND,Testa JR,Smith DI

    更新日期:1992-12-01 00:00:00

  • Functional characterization of the human PAX3 gene regulatory region.

    abstract::Spatiotemporal expression of the PAX3 gene is tightly regulated during development. We have isolated and sequenced the 5'-flanking regulatory region of human PAX3. Primer extension and ribonuclease protection mapping revealed that transcription is initiated from a single start site downstream of a TATA-like motif in h...


    pub_type: 杂志文章


    authors: Okladnova O,Syagailo YV,Tranitz M,Riederer P,Stöber G,Mössner R,Lesch KP

    更新日期:1999-04-01 00:00:00

  • Cloning of the human SIX1 gene and its assignment to chromosome 14.

    abstract::The recently described murine homeobox genes, Six1 and Six2, which are expressed during development in limb tendons, have also been shown to be expressed in skeletal and smooth muscle, respectively. We have cloned and sequenced a human SIX1 cDNA and shown by Northern blotting that it is expressed in adult skeletal mus...


    pub_type: 杂志文章


    authors: Boucher CA,Carey N,Edwards YH,Siciliano MJ,Johnson KJ

    更新日期:1996-04-01 00:00:00

  • A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.

    abstract::Mutations in MCOLN1 have been found to cause mucolipidosis type IV (MLIV; MIM 252650), a rare autosomal recessive lysosomal storage disorder found primarily in the Ashkenazi Jewish population. As a part of the successful cloning of MCOLN1, we constructed a 1.4-Mb physical map containing 14 BACs and 4 cosmids that enco...


    pub_type: 杂志文章


    authors: Acierno JS Jr,Kennedy JC,Falardeau JL,Leyne M,Bromley MC,Colman MW,Sun M,Bove C,Ashworth LK,Chadwick LH,Schiripo T,Ma S,Goldin E,Schiffmann R,Slaugenhaupt SA

    更新日期:2001-04-15 00:00:00

  • Physical mapping studies on the human X chromosome in the region Xq27-Xqter.

    abstract::We have characterized three terminal deletions of the long arm of the X chromosome. Southern analysis using Xq27/q28 probes suggests that two of the deletions have breakpoints near the fragile site at Xq27.3. Flow karyotype analysis provides an estimate of 12 X 10(6) bp for the size of the deleted region. We have not ...


    pub_type: 杂志文章


    authors: Patterson M,Schwartz C,Bell M,Sauer S,Hofker M,Trask B,van den Engh G,Davies KE

    更新日期:1987-12-01 00:00:00

  • Three murine cataract mutants (Cat2) are defective in different gamma-crystallin genes.

    abstract::A number of murine cataract mutations have been localized to chromosome 1 close to the gamma-crystallin gene cluster (Cryg) (Everett et al., 1994, Genomics 20: 429-434; Löster et al., 1994, Genomics 23: 240-242). Based on the size of the mapping or allelism tests they have not been shown to be genetically distinct and...


    pub_type: 杂志文章


    authors: Klopp N,Favor J,Löster J,Lutz RB,Neuhäuser-Klaus A,Prescott A,Pretsch W,Quinlan RA,Sandilands A,Vrensen GF,Graw J

    更新日期:1998-09-01 00:00:00