Abstract:
:Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for LFA-1, a beta 2 leukocyte integrin. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses. We have mapped this gene to proximal mouse chromosome 9 by using mouse-hamster somatic cell hybrids and an interspecies backcross. Since human ICAM-1 maps to chromosome 19, it joins the LDL receptor to establish a new conserved syntenic segment between human chromosome 19 and proximal mouse chromosome 9. Murine Icam-1 maps between Cbl-2 and the centromere in the same region as one of the susceptibility genes for insulin-dependent diabetes mellitus (Idd-2) that is postulated to play a role in immune function and inflammation leading to insulitis. The mapping of Icam-1 to the region known to contain the Idd-2 gene raises the question of whether the phenotypic differences attributed to the Idd-2 locus might be due to genetic variation in Icam-1.
journal_name
Genomicsjournal_title
Genomicsauthors
Ballantyne CM,Kozak CA,O'Brien WE,Beaudet ALdoi
10.1016/0888-7543(91)90423-csubject
Has Abstractpub_date
1991-03-01 00:00:00pages
547-50issue
3eissn
0888-7543issn
1089-8646pii
0888-7543(91)90423-Cjournal_volume
9pub_type
杂志文章相关文献
GENOMICS文献大全abstract::The physical distance between DNA sequences in interphase nuclei was determined using eight cosmids containing fragments of the Chinese hamster genome that span 273 kb surrounding the dihydrofolate reductase (DHFR) gene. The distance between these sequences at the molecular level has been determined previously by rest...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90112-2
更新日期:1989-11-01 00:00:00
abstract::Whole-cell fusion between zebrafish fibroblast-like ZF4 cells and mouse B78 melanoma cells resulted in hybrids containing one or a few zebrafish chromosome segments in a murine chromosomal background. Fluorescence in situ hybridization to hybrid cell metaphases with a zebrafish genomic DNA probe revealed that many hyb...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0159
更新日期:1996-04-01 00:00:00
abstract::Mapping of 33 anonymous DNA probes and 12 genes to the long arm of chromosome 16 was achieved by the use of 14 mouse/human hybrid cell lines and the fragile site FRA16B. Two of the hybrid cell lines contained overlapping interstitial deletions in bands q21 and q22.1. The localization of the 12 genes has been refined. ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90313-4
更新日期:1991-06-01 00:00:00
abstract::It is hypothesized that autosomal retroposons compensate for the loss of their inactivated essential X-chromosome progenitors during spermatogenesis. Here we test this Retroposon Compensatory Mechanism (RCM) hypothesis using the Zfy gene family. The mouse autosomal retroposon Zfa is expressed in testes at the same dev...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00155-1
更新日期:2003-09-01 00:00:00
abstract::Circular RNAs (circRNAs) are a new kind of endogenous non-coding RNAs, which have been discovered continuously. More and more studies have shown that circRNAs are related to the occurrence and development of human diseases. Identification of circRNAs associated with diseases can contribute to understand the pathogenes...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.08.001
更新日期:2020-03-01 00:00:00
abstract::We describe here the cloning and characterization of the human gene ERMAP, identified by subtractive hybridization using early and late gestation human fetal liver. By in situ hybridization, we found human ERMAP to be expressed not only in erythoid cells in fetal liver and adult bone marrow, but also in reticulocytes ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2001.6600
更新日期:2001-08-01 00:00:00
abstract::Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCKAR and CCKBR. In an effort to determine whether the CCKA and CCKB receptors may be associated with certain CNS or gastrointestinal diseases, we have localized and compared the human and mouse chromosomal loci...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80018-h
更新日期:1995-02-10 00:00:00
abstract::Chromosomal locations have been assigned to seven members of the TGF-beta superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90480-i
更新日期:1990-03-01 00:00:00
abstract::To increase the number of markers on distal mouse chromosome 4, knowledge of the synteny homology between this region and human chromosome 1p (HSA1p) was used to identify candidate homologous mouse genes. Ten probes corresponding to loci on human chromosome 1p were tested to reveal polymorphisms between C57BL/6 and DB...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1485
更新日期:1994-09-01 00:00:00
abstract::Brachyuran crabs comprise the most species-rich clade among the crustacean order Decapoda and are divided into several major superfamilies. However, the monophyly of the superfamilies Ocypodoidea and Grapsoidea in their current compositions within the Brachyura remains inconclusive. In this study, the complete mitocho...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.06.004
更新日期:2020-01-01 00:00:00
abstract::We show a mute 9.1-kb gap in the human genome reference map, unraveled by RDA studies, to be a worldwide deletion/insertion polymorphism of stable type. The molecular and population data presented suggest its origin from a unique ancestral transposition event in chromosomal region 22q11.2, overlapping the IglambdaV ge...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.7014
更新日期:2002-12-01 00:00:00
abstract::In this report we define the genes of two-component regulatory systems in rice through a comprehensive computational analysis of rice (Oryza sativa L.) genome sequence databases. Thirty-seven genes were identified, including 5 HKs (cytokinin-response histidine protein kinase) (OsHK1-4, OsHKL1), 5 HPs (histidine phosph...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.02.001
更新日期:2007-06-01 00:00:00
abstract::Afrotheria genome size is reported to be over 50% larger than that of human, but we show that this is a gross overestimate. Although genome sequencing in Afrotheria is not complete, extensive homology with human has been revealed by chromosome painting. We provide new data on chromosome size and GC content in four Afr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2013.09.002
更新日期:2013-11-01 00:00:00
abstract::Expressed sequence tags (ESTs) have been obtained from several hundred brain cDNAs as an initial effort to characterize expressed brain genes. These ESTs will become tools for human genome mapping and they will also provide candidate causative genes for inherited disorders affecting the central nervous system. We have...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90439-y
更新日期:1992-03-01 00:00:00
abstract::Tandem repetitive sequences are DNA motifs common in the genomes of eukaryotic species and are often embedded in heterochromatic regions. In most eukaryotes, ribosomal genes, as well as centromeres and telomeres or subtelomeres, are associated with abundant tandem arrays of repetitive sequences and typically represent...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2008.04.008
更新日期:2008-08-01 00:00:00
abstract::Interspersed repetitive sequence (IRS) PCR and repetitive element-to-bubble (IRS-bubble) PCR have been utilized to rapidly generate large numbers of mouse-specific, chromosome 1-enriched STSs from mouse-hamster somatic cell hybrids. Single-strand conformational polymorphism (SSCP) has been used to localize 39 new repe...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(11)80007-8
更新日期:1993-12-01 00:00:00
abstract::The 19 chromosomal pairs of the swine karyotype are resolved into 18 peaks denoted A to Q and Y by dual-beam flow cytometry. The chromosomal content of six peaks has previously been determined by analyzing male/female differences, karyotypes of animals carrying translocations, and PCR studies of genes with known assig...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1146
更新日期:1993-04-01 00:00:00
abstract::The gene responsible for the second form of autosomal dominant polycystic kidney disease, PKD2, has recently been identified. We now describe the cloning, genomic localization, cDNA sequence, and expression analysis of its murine homologue, Pkd2. The cloned cDNA sequence is 5134 bp long and is predicted to encode a 96...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4920
更新日期:1997-10-01 00:00:00
abstract::The intercellular adhesion molecules ICAM1 and ICAM2 are the cell-surface ligands for the lymphocyte function-associated antigen LFA-1 (CD11a/CD18) and are thought to mediate cell-cell adhesion interactions required by the immune system. However, differences in tissue distribution, inducibility of expression, and over...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90157-a
更新日期:1991-10-01 00:00:00
abstract::Protein sequences were compared among Arabidopsis, Oryza and Populus to identify differential gene (DG) sets that are in one but not the other two genomes. The DG sets were screened against a plant transcript database, the NR protein database and six newly-sequenced genomes (Carica, Glycine, Medicago, Sorghum, Vitis a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.01.002
更新日期:2009-05-01 00:00:00
abstract::Thirteen moderately to highly informative microsatellite DNA polymorphisms based on (dC-dA)n.(dG-dT)n repeats were mapped to segments of human chromosome 5 using both linkage analysis and a panel of somatic cell hybrids which contained rearranged chromosomes. The markers were distributed throughout most of the length ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90077-r
更新日期:1991-11-01 00:00:00
abstract::Understanding differences in the repertoire of orthologous gene pairs is vital for interpretation of pharmacological and physiological experiments if conclusions are conveyed between species. Here we present a comprehensive dataset for G protein-coupled receptors (GPCRs) in both human and mouse with a phylogenetic roa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.04.001
更新日期:2006-09-01 00:00:00
abstract::We describe the isolation and characterization of a human gene (CLCN3) and its murine homologue (Clcn3) sharing significant sequence and structural similarities with all previously identified members of the voltage-gated chloride channel (ClC) family. This gene is expressed primarily in tissues derived from neuroectod...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1015
更新日期:1995-05-01 00:00:00
abstract::Chimpanzees are naturally and asymptomatically infected by simian immunodeficiency virus (SIV). Pathogenic properties of SIV/HIV vary and differences in susceptibility and pathogenicity of SIV/HIV depend in part on host-specific factors such as virus-receptor/co-receptor interactions. Since CD4 plays a primary role in...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2008.07.003
更新日期:2008-11-01 00:00:00
abstract::Most teleosts undergo a thyroid hormone (TH) regulated larval to juvenile transition known as metamorphosis. In Pleuronectiformes (flatfish), metamorphosis is most dramatic, and one eye of the symmetric pelagic larvae migrates to the opposite side of the head, giving rise to an asymmetric benthic juvenile with both ey...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.04.011
更新日期:2020-01-01 00:00:00
abstract::We have mapped 13 loci on mouse Chromosome 18 by Southern blot analysis of restriction fragment length polymorphisms among progeny from an interspecific backcross: (C57BL/6J X Mus spretus) X M. spretus. Complete haplotype analysis of 136 of these progeny was used to establish gene order and estimate genetic distances ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90029-r
更新日期:1992-08-01 00:00:00
abstract::Cri-du-chat is a chromosomal deletion syndrome characterized by partial deletion of the short arm of chromosome 5. The clinical symptoms include growth and mental retardation, microcephaly, hypertelorism, epicanthal folds, hypotonia, and a high-pitched monochromatic cry that is usually considered diagnostic for the sy...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1582
更新日期:1994-11-01 00:00:00
abstract::Receiver operating characteristic (ROC) has been widely used to evaluate statistical methods, but a fatal problem is that ROC cannot evaluate estimation of the false discovery rate (FDR) of a statistical method and hence the area under of curve as a criterion cannot tell us if a statistical method is conservative. To ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2011.05.006
更新日期:2011-11-01 00:00:00
abstract::Cytogenetic studies of banded chromosomes and fluorescence in situ hybridization (FISH) of several yeast artificial chromosomes (YACs) that are part of a 128-kb resolution physical map of a portion of 12q13 revealed that 4/14 (28%) lipomas have breakpoints in 12q13. These breakpoints are more than 10 Mb away from the ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4993
更新日期:1997-11-15 00:00:00
abstract::The chromosomal locations of mouse DNA sequences homologous to a feline cDNA clone encoding glutamic acid decarboxylase (GAD) were determined. Although cats and humans are thought to have only one gene for GAD, GAD cDNA sequences hybridize to two distinct chromosomal loci in the mouse, chromosomes 2 and 10. The chromo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90455-4
更新日期:1990-01-01 00:00:00