Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9.

Abstract:

:Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for LFA-1, a beta 2 leukocyte integrin. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses. We have mapped this gene to proximal mouse chromosome 9 by using mouse-hamster somatic cell hybrids and an interspecies backcross. Since human ICAM-1 maps to chromosome 19, it joins the LDL receptor to establish a new conserved syntenic segment between human chromosome 19 and proximal mouse chromosome 9. Murine Icam-1 maps between Cbl-2 and the centromere in the same region as one of the susceptibility genes for insulin-dependent diabetes mellitus (Idd-2) that is postulated to play a role in immune function and inflammation leading to insulitis. The mapping of Icam-1 to the region known to contain the Idd-2 gene raises the question of whether the phenotypic differences attributed to the Idd-2 locus might be due to genetic variation in Icam-1.

journal_name

Genomics

journal_title

Genomics

authors

Ballantyne CM,Kozak CA,O'Brien WE,Beaudet AL

doi

10.1016/0888-7543(91)90423-c

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

547-50

issue

3

eissn

0888-7543

issn

1089-8646

pii

0888-7543(91)90423-C

journal_volume

9

pub_type

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