Abstract:
:The gene coding for the alpha 5 chian of type IV collagen (alpha 5(IV) collagen), which maps to Xq22, is a candidate gene for the X-linked dominant disease Alport syndrome (AS). Using three cDNA clones, covering the 3' end of the alpha 5(IV) collagen gene, 3 of 38 patients have been identified with mutations in this gene. Each of these patients shows a gross rearrangement of DNA: a deletion of at least 35 kb, an insertion/deletion event involving approximately 25 kb, and a duplication of at least 35 kb of DNA.
journal_name
Genomicsjournal_title
Genomicsauthors
Boye E,Vetrie D,Flinter F,Buckle B,Pihlajaniemi T,Hamalainen ER,Myers JC,Bobrow M,Harris Adoi
10.1016/0888-7543(91)90040-lsubject
Has Abstractpub_date
1991-12-01 00:00:00pages
1125-32issue
4eissn
0888-7543issn
1089-8646pii
0888-7543(91)90040-Ljournal_volume
11pub_type
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