Abstract:
:The LIM domain is a structural motif that is well conserved throughout evolution in a variety of factors known to play important roles in development and cell regulation. Ldb genes encode LIM domain-binding (Ldb) factors. Here we report on the structural organization and chromosomal localization of the mouse Ldb1 gene. It contains at least 10 exons and spans approximately 4 kb of genomic DNA. The transcription initiation site is located 462 bp upstream of the translation initiation codon ATG as determined by 5'-RACE. Sequencing analysis of the 5'-flanking region shows TATA and CCAAT motifs as well as potential binding sites for GATA, CF-1, PEA3, HRE, APRRE, RARE, Myc, and c-Jun. Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic with human chromosome 10q.
journal_name
Genomicsjournal_title
Genomicsauthors
Yamashita T,Agulnick AD,Copeland NG,Gilbert DJ,Jenkins NA,Westphal Hdoi
10.1006/geno.1997.5163subject
Has Abstractpub_date
1998-02-15 00:00:00pages
87-92issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(97)95163-6journal_volume
48pub_type
杂志文章相关文献
GENOMICS文献大全abstract::The transcriptional organization of the region of the mouse X chromosome between the G6pd and the Fln1 genes was studied in detail, and it was compared with the syntenic region of the human chromosome. A cosmid contig of 250 kb was constructed by screening mouse cosmid libraries with probes for human genes and with wh...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1164
更新日期:1995-08-10 00:00:00
abstract::We have analyzed tumor and lymphocyte DNA from six breast cancer patients by one- and two-dimensional DNA fingerprinting using micro- and minisatellite core probes to estimate the extent and nature of DNA alterations in tumors. Both approaches were compared regarding sensitivity in genome analysis. We find that the nu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1284
更新日期:1993-07-01 00:00:00
abstract::Human chromosome 11 harbors many genes of medical significance and cancer-related rearrangements. The availability of cloned DNA in cosmids and in yeast artificial chromosomes (YACs), combined with fluorescence in situ hybridization analysis, has led to the cloning of genes at sites of chromosomal breakpoints in acute...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1354
更新日期:1994-07-01 00:00:00
abstract::The sequence of the gorilla alpha-fetoprotein gene, including 869 base pairs of the 5' flanking region and 4892 base pairs of the 3' flanking region (24,607 in total), was determined from two overlapping lambda phage clones. The sequence extends 18,846 base pairs from the Cap site to the polyadenylation site, and it r...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90221-y
更新日期:1991-01-01 00:00:00
abstract::TM4SF11 is only 102 kb from the chemokine gene cluster composed of SCYA22, SCYD1, and SCYA17 on chromosome 16q13. CKLF maps on chromosome 16q22. CKLFs have some characteristics associated with the CCL22/MDC, CX3CL1/fractalkine, CCL17/TARC, and TM4SF proteins. Bioinformatics based on CKLF2 cDNA and protein sequences in...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00095-8
更新日期:2003-06-01 00:00:00
abstract::The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved seg...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6130
更新日期:2000-04-01 00:00:00
abstract::Use of mixed models is in the spotlight as an emerging method for genome-wide association studies (GWASs). This study investigated the statistical power for identifying nucleotide variants associated with quantitative traits using the mixed model methodology. Quantitative traits were simulated through design of herita...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2014.11.001
更新日期:2015-01-01 00:00:00
abstract::Usher syndrome type 1 (USH1) is an autosomal recessive, genetically heterogeneous disorder causing severe congenital deafness, retinitis pigmentosa, and vestibular dysfunction. The USHla locus located on 14q32 has been linked to the genetic markers D14S250 and D14S78. Using D14S250 and D14S78, we have isolated two non...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4779
更新日期:1997-07-01 00:00:00
abstract::Syndactyly in Holstein cattle is an autosomal recessive abnormality characterized by the fusion of the functional digits. This disorder has been previously mapped to the telomeric part of bovine chromosome 15. Here, we describe the fine-mapping of syndactyly in Holstein cattle to a 3.5-Mb critical interval using a com...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.05.007
更新日期:2006-11-01 00:00:00
abstract::Physical activity enhances muscle mitochondrial gene expression, while inactivity and mitochondrial dysfunction are both risk factors for developing diabetes. Defective activation of the transcriptional coactivator PGC-1alpha may contribute to the gene expression pattern observed in diabetic and insulin-resistant skel...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2005.09.007
更新日期:2006-01-01 00:00:00
abstract::The objective of this study was to identify gene expression differences in blood differences in children with autism (AU) and autism spectrum disorder (ASD) compared to general population controls. Transcriptional profiles were compared with age- and gender-matched, typically developing children from the general popul...
journal_title:Genomics
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ygeno.2007.09.003
更新日期:2008-01-01 00:00:00
abstract::The genome sequence of Mycobacterium tuberculosis strain H37Rv is an important and valuable reference point in the study of M. tuberculosis phylogeny, molecular epidemiology, and drug-resistance mutations. However, it is becoming apparent that use of H37Rv as a sole reference genome in analysing clinical isolates pres...
journal_title:Genomics
pub_type: 杂志文章,评审
doi:10.1016/j.ygeno.2017.07.004
更新日期:2017-10-01 00:00:00
abstract::We discuss the statistical significance of local similarities found between DNA sequences, and illustrate the procedure with reference to the Queen and Korn algorithm. If the longest similarity found for two sequences has length L, this length is said to be significant at the 5% level if there is a probability of no m...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(88)90081-x
更新日期:1988-10-01 00:00:00
abstract::A comparison study of short SAGE versus GeneChip and long SAGE was conducted to determine if data were interchangeable between the techniques. Although SAGE and Affymetrix chip expression levels showed a significant correlation using the set of genes for which there was reliable and unambiguous mapping from tag-to-gen...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.06.014
更新日期:2004-10-01 00:00:00
abstract::The Lp mouse mutant provides a model for the severe human neural tube defect (NTD), cranio-rachischisis. To identify the Lp gene, a positional cloning approach has been adopted. Previously, linkage analysis in a large intraspecific backcross was used to map the Lp locus to distal mouse chromosome 1. Here we report a d...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5701
更新日期:1999-03-01 00:00:00
abstract::The AFLP technique is a new DNA marker technology based on the selective amplification of restriction fragments. Multiple polymorphic markers are simultaneously produced and can be tested in one PCR. No prior information on genomic DNA sequences is needed. In the current study, we contribute 18 AFLP markers to the lin...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0562
更新日期:1996-11-01 00:00:00
abstract::We describe here a new type of X-linked liver glycogen storage disease. The main symptoms include liver enlargement and growth retardation. The clinical and biochemical abnormalities of this glycogenosis are similar to those of classical X-linked liver glycogenosis due to phosphorylase kinase deficiency (XLG). However...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1322
更新日期:1994-06-01 00:00:00
abstract::A genetic basis for neural tube defects (NTD) is rarely doubted, but the genes involved have not yet been identified. This is partly due to a lack of suitable families on which to perform linkage analysis. An alternative approach is to use the many mouse genes that cause NTD as a means of isolating their human homolog...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80165-i
更新日期:1995-04-10 00:00:00
abstract::Flowering is a prerequisite for pear fruit production. Therefore, the development of flower buds and the control of flowering time are important for pear trees. However, the molecular mechanism of pear flowering is unclear. SOC1, a member of MADS-box family, is known as a flowering signal integrator in Arabidopsis. We...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.09.011
更新日期:2020-03-01 00:00:00
abstract::The Gnas locus is highly complex and encodes several oppositely imprinted and alternatively spliced transcripts. Gnas itself encodes Gsalpha, which is involved in endocrine function and bone development, but the roles for the other transcripts have not been established. Here we describe a mouse mutation that provides ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.6842
更新日期:2002-10-01 00:00:00
abstract::We report monozygotic twin girls with syndromic intellectual disability who underwent exome sequencing but with negative pathogenic variants. To search for variants that are unrecognized by exome sequencing, high-fidelity long-read genome sequencing (HiFi LR-GS) was applied. A 12-kb copy-neutral inversion was precisel...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.038
更新日期:2020-11-04 00:00:00
abstract::Balanced reciprocal translocation carriers are usually phenotypically normal but are at an increased risk of infertility, recurrent miscarriage or having affected children. Preimplantation genetic testing on chromosomal structural rearrangement (PGT-SR) offers a way to screen against unbalanced embryos. Here, we demon...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.04.001
更新日期:2020-01-01 00:00:00
abstract::TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy of H3K4me...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2012.07.006
更新日期:2012-11-01 00:00:00
abstract::On the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacter...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00008-9
更新日期:2003-05-01 00:00:00
abstract::Alternative splicing is an important mechanism mediating the function of genes in multicellular organisms. Recently, we discovered a new splicing-junction wobble mechanism that generates subtle alterations in mRNA by randomly selecting tandem 5' and 3' splicing-junction sites. Here we developed a sensitive approach to...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.07.004
更新日期:2006-12-01 00:00:00
abstract::Duplicated segments of genomic DNA can catalyze both gene evolution and chromosome evolution. Here we describe a rodent-specific duplication involving the Uqcrb gene, a cis-regulatory element for the Gdf6 gene, and a chromosomal rearrangement. Comparisons of Gdf6 sequences from several placental mammals and platypus r...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.07.009
更新日期:2004-11-01 00:00:00
abstract::Genes homologous to those located on human chromosome 4 (HSA4) were mapped in the bovine to determine regions of syntenic conservation among humans, mice, and cattle. Previous studies have shown that two homologs of genes on HSA4, PGM2 and PEPS, are located in bovine syntenic group U15 (chromosome 6). The homologous m...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(05)80295-2
更新日期:1992-09-01 00:00:00
abstract:AIM:The objective of this study is to examine the alterations in the levels of expression of serum lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283 in spinal cord injured (SCI) patients versus healthy control. METHOD:The expression of the selected RNAs in the sera was determined in 23 patients suffering from acute spinal cord i...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.06.018
更新日期:2020-09-01 00:00:00
abstract::The field of molecular evolution started with the alignment of a few protein sequences in the early 1960s. Among the first results found, the genetic equidistance result has turned out to be the most unexpected. It directly inspired the ad hoc universal molecular clock hypothesis that in turn inspired the neutral theo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2016.03.002
更新日期:2016-07-01 00:00:00
abstract::Sequence tag count-based gene expression analysis is potent for the identification of candidate genes relevant to the cancerous phenotype. With the public availability of count-based data, the computational approaches for differentially expressed genes, which are mainly based on Binomial or beta-Binomial distribution,...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.05.003
更新日期:2009-09-01 00:00:00