Abstract:
:The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved segment: CASP2 and PRSS1 are localized to 7q35, while NPY is localized to 7p15.1. This raises the question whether the human homologue of Lyp is linked to CASP2/PRSS1 or to NPY. We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35.
journal_name
Genomicsjournal_title
Genomicsauthors
Hornum L,Markholst Hdoi
10.1006/geno.2000.6130subject
Has Abstractpub_date
2000-04-01 00:00:00pages
81-3issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(00)96130-5journal_volume
65pub_type
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