Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH.

Abstract:

:The ADH7 gene encoding human Class IV (sigma) alcohol dehydrogenase (ADH) was cloned from a Caucasian genomic DNA library and characterized. It has nine exons and eight introns that span about 22 kb, and its intron insertion is identical to that of the other ADH genes (ADH1 to ADH5). The nucleotide sequences of the exons encoding 374 amino acids are identical to the previously reported cDNA sequence of sigma ADH. Fluorescence in situ hybridization analysis showed that ADH7 is located on human chromosome 4q23-q24, close to the ADH cluster locus (4q21-q25). These data are consistent with the view that Class IV ADH is a member of the ADH family and is phylogenetically close to the other ADHs.

journal_name

Genomics

journal_title

Genomics

authors

Yokoyama H,Baraona E,Lieber CS

doi

10.1006/geno.1996.0040

subject

Has Abstract

pub_date

1996-01-15 00:00:00

pages

243-5

issue

2

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(96)90040-3

journal_volume

31

pub_type

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