Abstract:
:The ADH7 gene encoding human Class IV (sigma) alcohol dehydrogenase (ADH) was cloned from a Caucasian genomic DNA library and characterized. It has nine exons and eight introns that span about 22 kb, and its intron insertion is identical to that of the other ADH genes (ADH1 to ADH5). The nucleotide sequences of the exons encoding 374 amino acids are identical to the previously reported cDNA sequence of sigma ADH. Fluorescence in situ hybridization analysis showed that ADH7 is located on human chromosome 4q23-q24, close to the ADH cluster locus (4q21-q25). These data are consistent with the view that Class IV ADH is a member of the ADH family and is phylogenetically close to the other ADHs.
journal_name
Genomicsjournal_title
Genomicsauthors
Yokoyama H,Baraona E,Lieber CSdoi
10.1006/geno.1996.0040subject
Has Abstractpub_date
1996-01-15 00:00:00pages
243-5issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(96)90040-3journal_volume
31pub_type
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