CancerProView: a graphical image database of cancer-related genes and proteins.

Abstract:

:We have developed a graphical image database CancerProView (URL: http://cancerproview.dmb.med.keio.ac.jp/php/cpv.html) to assist the search for alterations of the motifs/domains in the cancer-related proteins that are caused by mutations in the corresponding genes. For the CancerProView, we have collected various kinds of data on 180 cancer-related proteins in terms of the motifs/domains, genomic structures of corresponding genes, and 109 charts of the protein interaction pathways. Moreover, we have collected the relevant data on 1041 reference genes including 197 non-cancer disease-associated genes, and the nucleotide sequences for 2011 full-length cDNA's and the alternatively spliced transcript variants. Thus, the CancerProView database system would provide valuable information to facilitate basic cancer research as well as for designing new molecular diagnosis and drug discovery for cancers. The CancerProView database can be operated via Internet with any Web browser, and the system is freely available to interested users without ID and password.

journal_name

Genomics

journal_title

Genomics

authors

Mitsuyama S,Shimizu N

doi

10.1016/j.ygeno.2012.05.011

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

81-92

issue

2

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(12)00104-8

journal_volume

100

pub_type

杂志文章

相关文献

GENOMICS文献大全
  • Comparative mitochondrial genomic analysis of Macrophthalmus pacificus and insights into the phylogeny of the Ocypodoidea & Grapsoidea.

    abstract::Grapsoidea and Ocypodoidea, two of the most abundant and economically important groups in Brachyura, are of great commercial value to fisheries and aquaculture. However, the taxonomy of Ocypodoidea and Grapsoidea has long been highly disputed. Previous studies have investigated this problem through phylogenetic analys...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2019.12.012

    authors: Wang Q,Tang D,Guo H,Wang J,Xu X,Wang Z

    更新日期:2020-01-01 00:00:00

  • Identification and characterization of a human cDNA homologous to yeast SKI2.

    abstract::A monoclonal antibody, 170A1, which recognizes a nucleolar peptide of molecular weight 90,000, was raised. The protein was conserved among various vertebrates. To characterize the antigen, we screened a human fetal liver expression library using the monoclonal antibody as a probe. Molecular analyses of immunopositive ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(95)80008-a

    authors: Lee SG,Lee I,Park SH,Kang C,Song K

    更新日期:1995-02-10 00:00:00

  • The consequence of natural selection on genetic variation in the mouse.

    abstract::Laboratory mouse strains are known to have emerged from recent interbreeding between individuals of Mus musculus isolated populations. As a result of this breeding history, the collection of polymorphisms observed between laboratory mouse strains is likely to harbor the effects of natural selection between reproductiv...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2010.02.004

    authors: Reuveni E,Birney E,Gross CT

    更新日期:2010-04-01 00:00:00

  • Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12.

    abstract::Because of the conservation of the ubiquitin coding sequence and the number of transcriptionally active genes and reverse-transcribed pseudogenes, it has not been possible to use ubiquitin cDNA clones to map the functional ubiquitin genes. The UBB and UBC polyubiquitin genes have previously been mapped by the use of s...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1108

    authors: Webb GC,Baker RT,Coggan M,Board PG

    更新日期:1994-02-01 00:00:00

  • Regional localization of over 300 loci on human chromosome 22 using a somatic cell hybrid mapping panel.

    abstract::A somatic cell hybrid panel, consisting of 25 cell lines, has been developed to localize loci subregionally on chromosome 22. Over 300 markers in the form of STSs or hybridization probes have been assigned to one of 24 unique regions or "bins" using this panel. This ordered collection of markers will aid in the assemb...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.0358

    authors: Budarf ML,Eckman B,Michaud D,McDonald T,Gavigan S,Buetow KH,Tatsumura Y,Liu Z,Hilliard C,Driscoll D,Goldmuntz E,Meese E,Zwarthoff EC,Williams S,McDermid H,Dumanski JP,Biegel J,Bell CJ,Emanuel BS

    更新日期:1996-07-15 00:00:00

  • Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.

    abstract::Type A receptors of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, contain alpha, beta, delta, gamma, and rho subunits. The gamma subunit has four subtypes: gamma1, gamma2, gamma3, andgamma4. GABA(A) receptor-associated protein (GABARAP) was previously demonstrated to act as a linker protein between m...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.2001.6555

    authors: Xin Y,Yu L,Chen Z,Zheng L,Fu Q,Jiang J,Zhang P,Gong R,Zhao S

    更新日期:2001-06-15 00:00:00

  • Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

    abstract::We have isolated and chromosomally fine-mapped 16 novel genes belonging to the human zinc finger Krüppel family (ZNF131-140, 142, 143, 148, 151, 154, and 155), including 1 of the GLI type (ZNF143) and 3 containing a KRAB (Krüppel-associated box) segment (ZNF133, 136, and 140). Based on their map position, several of t...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1995.1040

    authors: Tommerup N,Vissing H

    更新日期:1995-05-20 00:00:00

  • Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor.

    abstract::We report the isolation of cDNA clones for the mouse alpha 7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind alpha-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in sc...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(95)80228-e

    authors: Orr-Urtreger A,Seldin MF,Baldini A,Beaudet AL

    更新日期:1995-03-20 00:00:00

  • A genomic region encompassing a cluster of olfactory receptor genes and a myosin light chain kinase (MYLK) gene is duplicated on human chromosome regions 3q13-q21 and 3p13.

    abstract::The olfactory receptor (OR) multigene family is widely distributed in the human genome. We characterize here a new cluster of four OR genes (HGMW-approved symbols OR7E20P, OR7E6P, OR7E21P, and OR7E22P) on human chromosome 3p13 that is contained in an approximately 250-kb region. This region has been physically mapped,...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5690

    authors: Brand-Arpon V,Rouquier S,Massa H,de Jong PJ,Ferraz C,Ioannou PA,Demaille JG,Trask BJ,Giorgi D

    更新日期:1999-02-15 00:00:00

  • Duplication/deficiency mapping of situs inversus viscerum (iv), a gene that determines left-right asymmetry in the mouse.

    abstract::A recessive mutation in the mouse, situs inversus viscerum (iv), results in randomization of organ position along the left-right body axis: approximately 50% of the progeny of homozygous matings exhibit situs solitus and 50% exhibit situs inversus. Recent studies have established genetic linkage between iv and the imm...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/s0888-7543(05)80163-6

    authors: McGrath J,Horwich AL,Brueckner M

    更新日期:1992-11-01 00:00:00

  • Comparative mapping of the human homologue of the rat diabetes susceptibility gene lyp to a 1.3-Mb segment on HSA7.

    abstract::The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved seg...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.2000.6130

    authors: Hornum L,Markholst H

    更新日期:2000-04-01 00:00:00

  • Machine learning method using position-specific mutation based classification outperforms one hot coding for disease severity prediction in haemophilia 'A'.

    abstract::Haemophilia is an X-linked genetic disorder in which A and B types are the most common that occur due to absence or lack of protein factors VIII and IX, respectively. Severity of the disease depends on mutation. Available Machine Learning (ML) methods that predict the mutational severity by using traditional encoding ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2020.09.020

    authors: Singh VK,Maurya NS,Mani A,Yadav RS

    更新日期:2020-11-01 00:00:00

  • Chromosomal deletion 4p15.32----p14 in a Treacher Collins syndrome patient: exclusion of the disease locus from and mapping of anonymous DNA sequences to this region.

    abstract::Treacher Collins syndrome is an autosomal dominant condition of bilateral craniofacial abnormalities of structures derived from the first and second branchial arches. A patient with severe manifestations of Treacher Collins syndrome and a de novo chromosomal deletion in region 4p15.32----p14 was identified. Anonymous ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(91)90117-w

    authors: Jabs EW,Coss CA,Hayflick SJ,Whitmore TE,Pauli RM,Kirkpatrick SJ,Meyers DA,Goldberg R,Day DW,Rosenbaum KN

    更新日期:1991-09-01 00:00:00

  • Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA.

    abstract::The association of the HLA class III region with many diseases motivates the investigation of unidentified genes in the 30-kb segment between complement component genes Bf and C4. RD, which codes for a putative RNA binding protein, is 205 bp downstream of Bf. SKI2W (HGMW-approved symbol SKIV2L), a DEVH-box gene probab...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5499

    authors: Yang Z,Shen L,Dangel AW,Wu LC,Yu CY

    更新日期:1998-11-01 00:00:00

  • Five-color-based high-information-content fingerprinting of bacterial artificial chromosome clones using type IIS restriction endonucleases.

    abstract::We have developed a high-information-content fingerprinting (HICF) system for bacterial artificial chromosome (BAC) clones using a Type IIS restriction endonuclease, HgaI, paired with a Type II restriction endonuclease, RsaI. In the method described, unknown five-base overhangs generated with HgaI are partially or ful...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.2001.6547

    authors: Ding Y,Johnson MD,Chen WQ,Wong D,Chen YJ,Benson SC,Lam JY,Kim YM,Shizuya H

    更新日期:2001-06-01 00:00:00

  • CLAN, a novel human CED-4-like gene.

    abstract::Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containin...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.2001.6579

    authors: Damiano JS,Stehlik C,Pio F,Godzik A,Reed JC

    更新日期:2001-07-01 00:00:00

  • Isolation and regional assignment of human chromosome 12p cDNAs.

    abstract::We have characterized 117 cDNAs isolated by direct cDNA selection using pools of human chromosome 12p cosmids. Sequencing revealed that 41 clones did overlap with other cDNAs. Of the remaining 76 cDNA sequences, 11 matched previously identified human chromosome 12p genes and 3 matched previously determined cDNA sequen...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1995.1213

    authors: Baens M,Aerssens J,van Zand K,Van den Berghe H,Marynen P

    更新日期:1995-09-01 00:00:00

  • Characterization of the polycystic kidney disease 2 gene promoter.

    abstract::The key regulatory elements for PKD2 transcription remain unclear. To identify these core elements, we characterized porcine PKD2 promoter with bioinformatics and molecular tools and found porcine PKD2 promoter bearing typical features of enriched CpG and less TATA. Further studies demonstrated that the core region wa...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2014.08.006

    authors: Wang Q,Han G,Ye J,Gao X,Niu H,Zhao J,Chai Y,Li N,Yin H

    更新日期:2014-12-01 00:00:00

  • Genome Annotator Light (GAL): A Docker-based package for genome analysis and visualization.

    abstract::Next generation sequencing techniques produce enormous data but its analysis and visualization remains a big challenge. To address this, we have developed Genome Annotator Light(GAL), a Docker based package for genome analysis and data visualization. GAL integrated several existing tools and in-house programs inside a...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2019.03.012

    authors: Panda A,Chaudhari NM,Tripathy S

    更新日期:2020-01-01 00:00:00

  • Epigenetic status of the H19 locus in human oocytes following in vitro maturation.

    abstract::Imprinting is an epigenetic modification that is reprogrammed in the germ line and leads to the monoallelic expression of some genes. Imprinting involves DNA methylation. Maternal imprint is reset during oocyte growth and maturation. In vitro maturation (IVM) of oocytes may, therefore, interfere with imprint acquisiti...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2005.10.008

    authors: Borghol N,Lornage J,Blachère T,Sophie Garret A,Lefèvre A

    更新日期:2006-03-01 00:00:00

  • Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes.

    abstract::The use of round spermatids that are fully active at the transcriptional level to create zygotes (i.e. round spermatid injection; ROSI) raises the question regarding the downregulation of all specific genes that are transcribed from the paternal genome at fertilization. In this study, we show that protamine 1 and 2 mR...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2007.12.004

    authors: Borghol N,Blachère T,Lefèvre A

    更新日期:2008-05-01 00:00:00

  • SNP identification, linkage disequilibrium, and haplotype analysis for a 200-kb genomic region in a Korean population.

    abstract::Understanding patterns of linkage disequilibrium (LD) across genomes may facilitate association mapping studies to localize genetic variants influencing complex diseases, a recognition that led to the International Haplotype Mapping Project (HapMap). Divergent patterns of haplotype frequency and LD across global popul...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2006.03.003

    authors: Kim KJ,Lee HJ,Park MH,Cha SH,Kim KS,Kim HT,Kimm K,Oh B,Lee JY

    更新日期:2006-11-01 00:00:00

  • Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.

    abstract::An arrayed library of human heterogeneous nuclear complementary (hnc) DNA was constructed from a somatic cell hybrid (M28) containing an i(12p) marker as the sole human chromosome. Heterogeneous nuclear (hn) RNA of M28 was used to synthesize first-strand hncDNA with a primer (RT) containing a random hexanucleotide at ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1993.1161

    authors: Baens M,Chaffanet M,Cassiman JJ,van den Berghe H,Marynen P

    更新日期:1993-04-01 00:00:00

  • Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster.

    abstract::Pulmonary surfactant consists of a complex mixture of phospholipids and several proteins essential to normal respiratory function. Two of the surfactant proteins, SP-A and SP-D, appear to have lectin-like activity relevant to the local phagocytic defense. Using polymerase chain reaction (PCR)-based somatic cell hybrid...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1993.1324

    authors: Kölble K,Lu J,Mole SE,Kaluz S,Reid KB

    更新日期:1993-08-01 00:00:00

  • Accelerated expansion of group IID-like phospholipase A2 genes in Bos taurus.

    abstract::Low-molecular-weight, calcium-dependent phospholipase A2 genes (PLA2s) that belong to the secreted type of PLA2s are clustered within a syntenic group on human 1p35-p36 and mouse 4qD3. We reassembled trace files available from the Whole Genome Sequencing (WGS) Project, obtaining an 86-kb contig with three tandem PLA2G...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2005.12.015

    authors: Golik M,Cohen-Zinder M,Loor JJ,Drackley JK,Band MR,Lewin HA,Weller JI,Ron M,Seroussi E

    更新日期:2006-04-01 00:00:00

  • Single-strand conformational polymorphism (SSCP) mapping of the mouse genome: integration of the SSCP, microsatellite, and gene maps of mouse chromosome 1.

    abstract::Interspersed repetitive sequence (IRS) PCR and repetitive element-to-bubble (IRS-bubble) PCR have been utilized to rapidly generate large numbers of mouse-specific, chromosome 1-enriched STSs from mouse-hamster somatic cell hybrids. Single-strand conformational polymorphism (SSCP) has been used to localize 39 new repe...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/s0888-7543(11)80007-8

    authors: Hunter KW,Watson ML,Rochelle J,Ontiveros S,Munroe D,Seldin MF,Housman DE

    更新日期:1993-12-01 00:00:00

  • Porcine KLF gene family: Structure, mapping, and phylogenetic analysis.

    abstract::The Kruppel-like factors (KLFs) belong to the family of zinc finger-containing transcription factors that regulates a diverse array of cellular processes, including cell proliferation, differentiation, and apoptosis. Here we reported the structure, mapping and phylogenetic analysis of KLF gene family in pigs. Comparat...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2009.11.001

    authors: Chen Z,Lei T,Chen X,Zhang J,Yu A,Long Q,Long H,Jin D,Gan L,Yang Z

    更新日期:2010-02-01 00:00:00

  • Physical and genetic maps for chromosome 10.

    abstract::A fluorescence in situ hybridization (FISH) physical map of 14 polymorphic loci on chromosome 10 covers over 62% of the fractional length of chromosome 10. The positions of three previously mapped loci are confirmed, nine more are refined, and two new loci are cytogenetically mapped. The order of loci determined by FI...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1993.1192

    authors: Lichter JB,Difilippantonio MJ,Pakstis AJ,Goodfellow PJ,Ward DC,Kidd KK

    更新日期:1993-05-01 00:00:00

  • Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay.

    abstract::Specific language impairment (SLI) is defined as failure to acquire normal language skills despite adequate intelligence and environmental stimulation. Although SLI disorders are often heritable, the genetic basis is likely to involve a number of risk factors. This study describes a 7-year-old girl carrying an inherit...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2005.04.002

    authors: Kwasnicka-Crawford DA,Carson AR,Roberts W,Summers AM,Rehnström K,Järvelä I,Scherer SW

    更新日期:2005-08-01 00:00:00

  • A yeast artificial chromosome contig of the critical region for cri-du-chat syndrome.

    abstract::Cri-du-chat is a chromosomal deletion syndrome characterized by partial deletion of the short arm of chromosome 5. The clinical symptoms include growth and mental retardation, microcephaly, hypertelorism, epicanthal folds, hypotonia, and a high-pitched monochromatic cry that is usually considered diagnostic for the sy...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1582

    authors: Goodart SA,Simmons AD,Grady D,Rojas K,Moyzis RK,Lovett M,Overhauser J

    更新日期:1994-11-01 00:00:00