Abstract:
:Histamine N-methyltransferase (HNMT), a cytosolic histamine-metabolizing enzyme, is the only known product of the 50-kb human HNMT. Here, a detailed investigation of HNMT products revealed the existence of a new brain mRNA product of HNMT. This species, named HNMT-Short (HNMT-S), encodes a 126-amino-acid protein. Northern blot analysis detected HNMT-S mRNA (1.0 kb) in placenta, but not in several other human tissues. In addition, unlike the known HNMT cDNA, HNMT-S cDNA did not result in histamine-methylating activity after transfection into COS-7 cells. These studies show that HNMT-S is a new mRNA species and putative protein product from HNMT. The physiological role of HNMT-S remains to be investigated.
journal_name
Genomicsjournal_title
Genomicsauthors
Barnes WG,Grinde E,Crawford DR,Herrick-Davis K,Hough LBdoi
10.1016/s0888-7543(03)00236-2subject
Has Abstractpub_date
2004-01-01 00:00:00pages
168-71issue
1eissn
0888-7543issn
1089-8646pii
S0888754303002362journal_volume
83pub_type
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