Abstract:
:The gene encoding activation-induced cytidine deaminase (AID), a member of the cytidine deaminase family, was isolated from a murine B cell lymphoma line, CH12F3-2, induced by combined stimulation of TGF-beta, IL-4, and CD40L. We have isolated the human orthologue of mouse AID cDNA, which has an open reading frame of 198 residues containing a conserved cytidine deaminase motif. The amino acid sequence of human AID is 92% identical to that of mouse AID. RT-PCR analysis of 15 human tissues showed that AID mRNA is expressed strongly in lymph nodes and tonsils. The complete human AID gene consisting of five exons was isolated and mapped to chromosome 12p13 by fluorescence in situ hybridization.
journal_name
Genomicsjournal_title
Genomicsauthors
Muto T,Muramatsu M,Taniwaki M,Kinoshita K,Honjo Tdoi
10.1006/geno.2000.6268subject
Has Abstractpub_date
2000-08-15 00:00:00pages
85-8issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(00)96268-2journal_volume
68pub_type
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