Abstract:
:In the interest of cloning and analyzing the genes responsible for two very different diseases, the Rubinstein-Taybi syndrome (RTS) and acute myeloid leukemia (AML) associated with the somatic translocation t(8;16)(p11;p13.3), we constructed a high-resolution restriction map of contiguous cosmids (contig) covering 1.2 Mb of chromosome 16p13.3. By fluorescence in situ hybridization and Southern blot analysis, we assigned all tested RTS and t(8;16) translocation breakpoints to a 100-kb region. We have previously reported exact physical locations of these 16p breakpoints, which all disrupt one gene we mapped to this interval: the CREB-binding protein (CBP or CREBBP) gene. Intriguingly, mutations in the CBP gene are responsible for RTS as well as the t(8;16)-associated AML. CBP functions as an integrator in the assembly of various multiprotein regulatory complexes and is thus necessary for transcription in a broad range of transduction pathways. We report here the cloning, physical mapping, characterization, and full cDNA nucleotide sequence of the human CBP gene.
journal_name
Genomicsjournal_title
Genomicsauthors
Giles RH,Petrij F,Dauwerse HG,den Hollander AI,Lushnikova T,van Ommen GJ,Goodman RH,Deaven LL,Doggett NA,Peters DJ,Breuning MHdoi
10.1006/geno.1997.4699subject
Has Abstractpub_date
1997-05-15 00:00:00pages
96-114issue
1eissn
0888-7543issn
1089-8646pii
S0888754397946991journal_volume
42pub_type
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