Effect of selenocystine on gene expression profiles in human keloid fibroblasts.


:In this study, selenocystine, a nutritionally available selenoamino acid, was identified for the first time as a novel agent with anti proliferative activity on human keloids. The 20 μM concentration after 48 h treatment used here was the most effective to reduce keloid fibroblast growth. We analyzed the gene expression profile of selenocystine treatment response in keloid fibroblasts by the microarray system to characterize the effects of selenocystine on human keloids. The major alterations in keloid fibroblasts following selenocystine exposure included up-regulation of the genes encoding cell death and transcription factors. Prominent down-regulation of genes involved in development, cell adhesion and cytoskeleton, as well as extra cellular matrix genes, usually strongly up-regulated in keloids, resulted following selenocystine exposure. The range of the down-regulated genes and the degree of the decreased expression appeared to be correlated with the degree of the morphological alterations in selenocystine treated keloids.






De Felice B,Garbi C,Wilson RR,Santoriello M,Nacca M




Has Abstract


2011-05-01 00:00:00
















  • High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16.

    abstract::More than 500 backcross progeny from four intersubspecific backcrosses were typed for six markers on distal mouse chromosome 16. Five of these represented genes that mapped within the Sod-1 to Ets-2 interval, which was shown previously to contain the weaver (wv) gene. The map order, including previously mapped referen...


    pub_type: 杂志文章


    authors: Mjaatvedt AE,Citron MP,Reeves RH

    更新日期:1993-08-01 00:00:00

  • Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).

    abstract::We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hyb...


    pub_type: 杂志文章


    authors: Arnemann J,Spurr NK,Wheeler GN,Parker AE,Buxton RS

    更新日期:1991-07-01 00:00:00

  • Homologies between human and marmoset (Callithrix jacchus) chromosomes revealed by comparative chromosome painting.

    abstract::Regions of DNA homology between human and marmoset (Callithrix jacchus) chromosomes have been demonstrated using fluorescence in situ hybridization. All 24 chromosome paints and two centromere repeat sequences from Homo sapiens (HSA) have been annealed to previously G-banded metaphase spreads of Callithrix jacchus. Al...


    pub_type: 杂志文章


    authors: Sherlock JK,Griffin DK,Delhanty JD,Parrington JM

    更新日期:1996-04-15 00:00:00

  • Improved gene targeting in C. elegans using counter-selection and Flp-mediated marker excision.

    abstract::Gene targeting is widely used for the precise manipulation of genes. However, in the model organism Caenorhabditis elegans non-transposon mediated gene targeting remains laborious, and as a result has not been widely used. One obstacle to the wider use of this approach is the difficulty of identifying homologous recom...


    pub_type: 杂志文章


    authors: Vázquez-Manrique RP,Legg JC,Olofsson B,Ly S,Baylis HA

    更新日期:2010-01-01 00:00:00

  • A single segment substitution line population for identifying traits relevant to drought tolerance and avoidance.

    abstract::A population of chromosome segment substitution lines was developed using KDML105 as the recurrent parent and one of DH212 (IR68586-F2-CA-143) or DH103 (IR68586-F2-CA-31) as the donor parent. The donor parents are part of a doubled haploid population from a cross between CT9993, an upland japonica accession, and IR622...


    pub_type: 杂志文章,评审


    authors: Shearman JR

    更新日期:2019-10-31 00:00:00

  • Genomic sequence, organization, and chromosomal localization of human JAK3.

    abstract::Members of the Janus (JAK) protein tyrosine kinase family including JAK3 have recently emerged as important components in cytokine signal transduction. Mutations of JAK3 have been found in a number of patients who present with severe combined immunodeficiency. To facilitate the further identification of JAK3-SCID pati...


    pub_type: 杂志文章


    authors: Riedy MC,Dutra AS,Blake TB,Modi W,Lal BK,Davis J,Bosse A,O'Shea JJ,Johnston JA

    更新日期:1996-10-01 00:00:00

  • Practicability of detecting somatic point mutation from RNA high throughput sequencing data.

    abstract::Traditionally, somatic mutations are detected by examining DNA sequence. The maturity of sequencing technology has allowed researchers to screen for somatic mutations in the whole genome. Increasingly, researchers have become interested in identifying somatic mutations through RNAseq data. With this motivation, we eva...


    pub_type: 杂志文章


    authors: Sheng Q,Zhao S,Li CI,Shyr Y,Guo Y

    更新日期:2016-05-01 00:00:00

  • A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.

    abstract::We completed a systematic survey of the human genome, conducted at an average resolution of 10 cM, for the identification of simple sequence tandem repeat polymorphisms (SSTRPs) that target new risk genes for Alzheimer disease (AD) by virtue of linkage disequilibrium. The efficiency of our association study was enhanc...


    pub_type: 杂志文章


    authors: Zubenko GS,Hughes HB,Stiffler JS,Hurtt MR,Kaplan BB

    更新日期:1998-06-01 00:00:00

  • SNP identification, linkage disequilibrium, and haplotype analysis for a 200-kb genomic region in a Korean population.

    abstract::Understanding patterns of linkage disequilibrium (LD) across genomes may facilitate association mapping studies to localize genetic variants influencing complex diseases, a recognition that led to the International Haplotype Mapping Project (HapMap). Divergent patterns of haplotype frequency and LD across global popul...


    pub_type: 杂志文章


    authors: Kim KJ,Lee HJ,Park MH,Cha SH,Kim KS,Kim HT,Kimm K,Oh B,Lee JY

    更新日期:2006-11-01 00:00:00

  • Analysis of the human VPS13 gene family.

    abstract::The gene mutated in chorea-acanthocytosis (CHAC; approved gene symbol VPS13A) encodes chorein, a protein similar to yeast Vps13p. We detected several similar putative human proteins by BLAST analysis of chorein. We characterized the structure of three new genes encoding these CHAC-similar proteins, located on chromoso...


    pub_type: 杂志文章


    authors: Velayos-Baeza A,Vettori A,Copley RR,Dobson-Stone C,Monaco AP

    更新日期:2004-09-01 00:00:00

  • The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome.

    abstract::SOX proteins are transcription factors that are characterized by a common DNA-binding motif known as the HMG domain. We describe the 5. 4-kb human SOX8 gene that codes for a 446-amino-acid protein and that is expressed strongly in brain and less abundantly in other tissues. SOX8 shows an overall identity of 47% to SOX...


    pub_type: 杂志文章


    authors: Pfeifer D,Poulat F,Holinski-Feder E,Kooy F,Scherer G

    更新日期:2000-01-01 00:00:00

  • Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor.

    abstract::The acyl-CoA binding protein (ACBP) and the diazepam binding inhibitor (DBI) or endozepine are independent isolates of a single 86-amino-acid, 10-kDa protein. ACBP/DBI is highly conserved between species and has been identified in several diverse organisms, including human, cow, rat, frog, duck, insects, plants, and y...


    pub_type: 杂志文章


    authors: Gersuk VH,Rose TM,Todaro GJ

    更新日期:1995-01-20 00:00:00

  • Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure.

    abstract::By optimizing the primer-annealing temperature in a rapid air cycling procedure, two human DNA sequences encoding centromere proteins B and C (CENP-B and CENP-C) were specifically amplified without any detectable amplification of highly homologous rodent DNA sequences. Using a panel of rodent/human hybrid DNA, the gen...


    pub_type: 杂志文章


    authors: Sugimoto K,Yata H,Himeno M

    更新日期:1993-07-01 00:00:00

  • Genomic structure of the locus associated with an insertional mutation in line 4 transgenic mice.

    abstract::In line 4 transgenic mice, six to eight copies of a 50-kb lambda recombinant clone are arranged in a head-to-tail tandem array on chromosome 3. Embryos homozygous for the transgene become arrested in their development on Day 5 of gestation shortly after implantation. The insertion site was cloned using a small segment...


    pub_type: 杂志文章


    authors: Mark WH,Signorelli K,Blum M,Kwee L,Lacy E

    更新日期:1992-05-01 00:00:00

  • Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line.

    abstract::High liver iron content is a risk factor for developing hepatocellular carcinoma (HCC). However, HCC cells are always iron-poor. Therefore, an association between hepatocyte iron storage capacity and differentiation is suggested. To characterize biological processes involved in iron loading capacity, we used a cDNA mi...


    pub_type: 杂志文章


    authors: Troadec MB,Glaise D,Lamirault G,Le Cunff M,Guérin E,Le Meur N,Détivaud L,Zindy P,Leroyer P,Guisle I,Duval H,Gripon P,Théret N,Boudjema K,Guguen-Guillouzo C,Brissot P,Léger JJ,Loréal O

    更新日期:2006-01-01 00:00:00

  • Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis.

    abstract::The ky mouse mutant, kyphoscoliosis, exhibits a degenerative muscle disease resulting in chronic deformation of the spinal column. Using an interspecific backcross segregating the ky mutation, we have mapped the ky locus to a small region of mouse chromosome 9. ky is nonrecombinant with the microsatellites D9Mit24 and...


    pub_type: 杂志文章


    authors: Skynner MJ,Gangadharan U,Coulton GR,Mason RM,Nikitopoulou A,Brown SD,Blanco G

    更新日期:1995-01-01 00:00:00

  • Molecular characterization of cystic fibrosis: 16 novel mutations identified by analysis of the whole cystic fibrosis conductance transmembrane regulator (CFTR) coding regions and splice site junctions.

    abstract::The spectrum of cystic fibrosis (CF) mutations was determined in 105 patients by using denaturing gradient gel electrophoresis to screen the entire coding regions and adjacent cystic fibrosis transmembrane conductance regulator (CFTR) gene sequences. The nucleotide substitutions detected included 16 novel mutations, 1...


    pub_type: 杂志文章


    authors: Fanen P,Ghanem N,Vidaud M,Besmond C,Martin J,Costes B,Plassa F,Goossens M

    更新日期:1992-07-01 00:00:00

  • Linkage mapping of human chromosome 10 microsatellite polymorphisms.

    abstract::Ten microsatellite DNA polymorphisms located on human chromosome 10 were regionally mapped using subchromosomal somatic cell hybrids and linkage analysis. The resulting order of the markers from pter-qter was [D10S89, D10S111], D10S107, D10S109, [D10S91, D10S110, D10S108, D10S88, D10S168], and D10S169. Order of the ma...


    pub_type: 杂志文章


    authors: Decker RA,Moore J,Ponder B,Weber JL

    更新日期:1992-03-01 00:00:00

  • The imprinted oedematous-small mutation on mouse chromosome 2 identifies new roles for Gnas and Gnasxl in development.

    abstract::The Gnas locus is highly complex and encodes several oppositely imprinted and alternatively spliced transcripts. Gnas itself encodes Gsalpha, which is involved in endocrine function and bone development, but the roles for the other transcripts have not been established. Here we describe a mouse mutation that provides ...


    pub_type: 杂志文章


    authors: Skinner JA,Cattanach BM,Peters J

    更新日期:2002-10-01 00:00:00

  • Comparative genome analysis and characterization of a MDR Klebsiella variicola.

    abstract::Klebsiella variicola is an emerging pathogen responsible for causing blood-stream infections, urinary and respiratory tract related diseases in humans. In this report, we describe the genome sequence data and phenotypic characterization of K. variicola strain KV093 isolated from India. Comparative genome sequence anal...


    pub_type: 杂志文章


    authors: Srinivasan VB,Rajamohan G

    更新日期:2020-09-01 00:00:00

  • X-linked recessive atrophic macular degeneration from RPGR mutation.

    abstract::We mapped a new X-linked recessive atrophic macular degeneration locus to Xp21.1-p11.4 and show allelic involvement of the gene RPGR, which normally causes severe peripheral retinal degeneration leading to global blindness. Ten affected males whom we examined had primarily macular atrophy causing progressive loss of v...


    pub_type: 杂志文章


    authors: Ayyagari R,Demirci FY,Liu J,Bingham EL,Stringham H,Kakuk LE,Boehnke M,Gorin MB,Richards JE,Sieving PA

    更新日期:2002-08-01 00:00:00

  • Localization of a gene for the human low-voltage EEG on 20q and genetic heterogeneity.

    abstract::The localization of a gene responsible for a normal variant of the human electroencephalogram to the distal part of chromosome 20q is reported. A linkage analysis, including 17 families with 191 individuals, tested with 73 RFLPs and 22 blood and serological markers, was performed for the low-voltage electroencephalogr...


    pub_type: 杂志文章


    authors: Steinlein O,Anokhin A,Yping M,Schalt E,Vogel F

    更新日期:1992-01-01 00:00:00

  • Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene.

    abstract::Insulin-like growth factor binding proteins (IGFBPs) constitute a family of at least six secreted proteins that bind insulin-like growth factors I and II (IGF-I and -II) and are capable of modifying IGF actions on target cells. We previously have purified an approximately 29-kDa IGFBP that is secreted by myoblasts dur...


    pub_type: 杂志文章


    authors: Kou K,Jenkins NA,Gilbert DJ,Copeland NG,Rotwein P

    更新日期:1994-04-01 00:00:00

  • YY1-dependent transcriptional regulation of the human GDAP1 gene.

    abstract::Charcot-Marie-Tooth disease (CMT) is a heritable neurodegenerative condition, some types of which (notably CMT4A) are caused by mutations in the GDAP1 gene that encodes a protein of unknown molecular function implicated in regulation of mitochondrial fission. Here we present for the first time a functional analysis of...


    pub_type: 杂志文章


    authors: Ratajewski M,Pulaski L

    更新日期:2009-12-01 00:00:00

  • Five-color-based high-information-content fingerprinting of bacterial artificial chromosome clones using type IIS restriction endonucleases.

    abstract::We have developed a high-information-content fingerprinting (HICF) system for bacterial artificial chromosome (BAC) clones using a Type IIS restriction endonuclease, HgaI, paired with a Type II restriction endonuclease, RsaI. In the method described, unknown five-base overhangs generated with HgaI are partially or ful...


    pub_type: 杂志文章


    authors: Ding Y,Johnson MD,Chen WQ,Wong D,Chen YJ,Benson SC,Lam JY,Kim YM,Shizuya H

    更新日期:2001-06-01 00:00:00

  • The human cystathionine beta-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms.

    abstract::Cystathionine beta-synthase [CBS; l-serine hydro-lyase (adding homocysteine), EC] catalyzes the first committed step of transsulfuration and is the enzyme deficient in classical homocystinuria. In this report, we describe the molecular cloning and the complete nucleotide sequence of the human CBS gene. We rep...


    pub_type: 杂志文章


    authors: Kraus JP,Oliveriusová J,Sokolová J,Kraus E,Vlcek C,de Franchis R,Maclean KN,Bao L,Bukovsk,Patterson D,Paces V,Ansorge W,Kozich V

    更新日期:1998-09-15 00:00:00

  • Polymorphisms in lipogenic genes and milk fatty acid composition in Holstein dairy cattle.

    abstract::Changing bovine milk fatty acid (FA) composition through selection can decrease saturated FA (SFA) consumption, improve human health and provide a means for manipulating processing properties of milk. Our study determined associations between milk FA composition and genes from triacylglycerol (TAG) biosynthesis pathwa...


    pub_type: 杂志文章


    authors: Nafikov RA,Schoonmaker JP,Korn KT,Noack K,Garrick DJ,Koehler KJ,Minick-Bormann J,Reecy JM,Spurlock DE,Beitz DC

    更新日期:2014-12-01 00:00:00

  • The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region.

    abstract::The intron-containing genes encoding rat and human ribosomal protein L19 (RPL19) have been cloned. The DNA sequences of the entire rat RPL19 gene and the 5' end of the human RPL19 gene have been determined. Sequence comparison of corresponding regions of the two genes reveals a striking interspecies homology in the 5'...


    pub_type: 杂志文章


    authors: Davies B,Fried M

    更新日期:1995-01-20 00:00:00

  • Construction of a gene map of the nephronophthisis type 1 (NPHP1) region on human chromosome 2q12-q13.

    abstract::A gene for the autosomal recessive kidney disorder juvenile nephronophthisis (NPH) is located on chromosome 2q between markers D2S1893 and D2S1888. Recently, the presence of large homozygous deletions was described in the majority of NPH patients. We constructed an integrated YAC/PAC contig of 54 markers and 30 PAC cl...


    pub_type: 杂志文章


    authors: Nothwang HG,Stubanus M,Adolphs J,Hanusch H,Vossmerbäumer U,Denich D,Kübler M,Mincheva A,Lichter P,Hildebrandt F

    更新日期:1998-01-15 00:00:00

  • Molecular cloning and characterization of canine ICOS.

    abstract::Inducible costimulatory receptor (ICOS) is one recently identified member of the CD28 family of costimulatory molecules. Evidence suggests ICOS functions as a critical immune regulator and, to evaluate these effects, we employed the canine model system that has been used to develop strategies currently in clinical use...


    pub_type: 杂志文章


    authors: Lee JH,Joo YD,Yim D,Lee R,Ostrander EA,Loretz C,Little MT,Storb R,Kuhr CS

    更新日期:2004-10-01 00:00:00